Influenza in Liver and Kidney Transplant Recipients: Incidence and Outcomes
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Influenza in Liver and Kidney Transplant Recipients : Incidence and Outcomes. / Arentoft, Nicoline Stender; Møller, Dina Leth; Knudsen, Andreas Delhbæk; Abdulovski, Ranya; Kirkby, Nikolai; Sørensen, Søren Schwartz; Rasmussen, Allan; Nielsen, Susanne Dam.
I: Microbiology Spectrum, Bind 11, Nr. 2, e03226-22, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Influenza in Liver and Kidney Transplant Recipients
T2 - Incidence and Outcomes
AU - Arentoft, Nicoline Stender
AU - Møller, Dina Leth
AU - Knudsen, Andreas Delhbæk
AU - Abdulovski, Ranya
AU - Kirkby, Nikolai
AU - Sørensen, Søren Schwartz
AU - Rasmussen, Allan
AU - Nielsen, Susanne Dam
N1 - Publisher Copyright: Copyright © 2023 Arentoft et al.
PY - 2023
Y1 - 2023
N2 - Influenza is a common respiratory tract infection in solid organ transplant (SOT) recipients. We aimed to investigate the incidence, risk factors, and complications of influenza in a large cohort of kidney and liver transplant recipients over 10 consecutive seasons. We conducted a retrospective study, including 378 liver and 683 kidney transplant recipients who were transplanted from January 1, 2010, to October 1, 2019. The data on influenza were retrieved from MiBa, which is a nationwide database that contains all of the microbiology results in Denmark. Clinical data were retrieved from patient records. Incidence rates and cumulative incidences were calculated, and risk factors were investigated using time-updated Cox proportional hazards models. The cumulative incidence of influenza in the first 5 years posttransplantation was 6.3% (95% CI: 4.7 to 7.9%). Of the 84 influenza positive recipients, 63.1% had influenza A, 65.5% were treated with oseltamivir, 65.5% were hospitalized, and 16.7% developed pneumonia. There were no significant differences in outcomes when comparing patients with influenza A and B. We found no significant effect of same-season influenza vaccination, sex, age, or comorbidities on the risk of acquiring influenza. The incidence of influenza in kidney and liver recipients is high, and 65.5% of infected transplant recipients required hospitalization. We were not able to confirm a reduction in influenza incidence or in the risk of complications associated with vaccination.
AB - Influenza is a common respiratory tract infection in solid organ transplant (SOT) recipients. We aimed to investigate the incidence, risk factors, and complications of influenza in a large cohort of kidney and liver transplant recipients over 10 consecutive seasons. We conducted a retrospective study, including 378 liver and 683 kidney transplant recipients who were transplanted from January 1, 2010, to October 1, 2019. The data on influenza were retrieved from MiBa, which is a nationwide database that contains all of the microbiology results in Denmark. Clinical data were retrieved from patient records. Incidence rates and cumulative incidences were calculated, and risk factors were investigated using time-updated Cox proportional hazards models. The cumulative incidence of influenza in the first 5 years posttransplantation was 6.3% (95% CI: 4.7 to 7.9%). Of the 84 influenza positive recipients, 63.1% had influenza A, 65.5% were treated with oseltamivir, 65.5% were hospitalized, and 16.7% developed pneumonia. There were no significant differences in outcomes when comparing patients with influenza A and B. We found no significant effect of same-season influenza vaccination, sex, age, or comorbidities on the risk of acquiring influenza. The incidence of influenza in kidney and liver recipients is high, and 65.5% of infected transplant recipients required hospitalization. We were not able to confirm a reduction in influenza incidence or in the risk of complications associated with vaccination.
KW - influenza
KW - kidney transplantation
KW - liver transplantation
KW - medical outcomes
KW - risk factors
KW - transplantation
KW - vaccines
U2 - 10.1128/spectrum.03226-22
DO - 10.1128/spectrum.03226-22
M3 - Journal article
C2 - 36976014
AN - SCOPUS:85158048613
VL - 11
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 2
M1 - e03226-22
ER -
ID: 366495188