Basis science research in pediatric urology studies physiological questions in animal models to provide new data on how to treat patients. We sat down with Jens-Christian Djurhuus to discuss both practical and philosophical questions on how to best perform basic science research. Initial questions such as “What type of questions are best studied in animal models?” and “Which animal model should I use?” help us answer the basic question of “What is a good research topic?”. To take advantage of his experience leading a research team, we went on to discuss “How do you lead a research team?” and “How do we make sure that basic science research translates to clinical practice?”. As research funding becomes scarce, we thank Professor Djurhuus for his insights on how to focus basic science research on relevant topics that are easily translatable to the care of children.