TY - JOUR

T1 - Effect of Stabilized Hypochlorous Acid on Re-epithelialization and Bacterial Bioburden in Acute Wounds

T2 - A Randomized Controlled Trial in Healthy Volunteers

AU - Burian, Ewa A.

AU - Sabah, Lubna

AU - Kirketerp-Møller, Klaus

AU - Gundersen, Glenn

AU - Ågren, Magnus S.

N1 - Publisher Copyright: © 2022, Medical Journals/Acta D-V. All rights reserved.

PY - 2022

Y1 - 2022

N2 - The aim of this randomized controlled trial was to eva-luate the wound-healing effect and antimicrobial properties of a novel stabilized hypochlorous acid solution on acute wounds, using a suction blister wound model. One suction blister was raised and de-roofed on each forearm in 20 healthy volunteers. Stabilized hypochlorous acid/control (sterile 0.9% NaCl) solutions were assigned to either wound by randomization. Wounds were irrigated and treated on days 0, 2 and 4. Re-epithelialization was assessed blindly by digital planimetry, and bacterial growth was assessed as the number of colony-forming units cultured from surface swabs. Hypochlorous acid solution increased the de-gree of re-epithelialization on day 4 by 14% compared with the control solution (95% confidence inter-val (CI) 6.8–20%, p = 0.00051) and was not inferior (p < 0.0001) to the control solution on day 10 (0.3%, 95% CI –1.3–1.9%). Median bacterial counts were lower with stabilized hypochlorous acid compared with control and were further reduced after irrigation and treatment of both groups on day 4, but remained lower in the stabilized hypochlorous acid group compared with the control group. This study demonstrat-es immediate and durable antimicrobial action and a bene ficial effect on acute wound healing after irrigation and treatment with a stabilized hypochlorous acid formulation.

AB - The aim of this randomized controlled trial was to eva-luate the wound-healing effect and antimicrobial properties of a novel stabilized hypochlorous acid solution on acute wounds, using a suction blister wound model. One suction blister was raised and de-roofed on each forearm in 20 healthy volunteers. Stabilized hypochlorous acid/control (sterile 0.9% NaCl) solutions were assigned to either wound by randomization. Wounds were irrigated and treated on days 0, 2 and 4. Re-epithelialization was assessed blindly by digital planimetry, and bacterial growth was assessed as the number of colony-forming units cultured from surface swabs. Hypochlorous acid solution increased the de-gree of re-epithelialization on day 4 by 14% compared with the control solution (95% confidence inter-val (CI) 6.8–20%, p = 0.00051) and was not inferior (p < 0.0001) to the control solution on day 10 (0.3%, 95% CI –1.3–1.9%). Median bacterial counts were lower with stabilized hypochlorous acid compared with control and were further reduced after irrigation and treatment of both groups on day 4, but remained lower in the stabilized hypochlorous acid group compared with the control group. This study demonstrat-es immediate and durable antimicrobial action and a bene ficial effect on acute wound healing after irrigation and treatment with a stabilized hypochlorous acid formulation.

KW - antiseptic

KW - clinical trial

KW - wound healing

KW - wound management

U2 - 10.2340/ACTADV.V102.1624

DO - 10.2340/ACTADV.V102.1624

M3 - Journal article

C2 - 35578822

AN - SCOPUS:85131217294

VL - 102

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

M1 - adv00727

ER -