C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

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Standard

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. / Timpson, N J; Nordestgaard, B G; Harbord, R M; Zacho, J; Frayling, T M; Tybjærg-Hansen, Anne; Smith, G D; Smith, G Davey.

I: International Journal of Obesity, Bind 35, Nr. 2, 01.02.2011, s. 300-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Timpson, NJ, Nordestgaard, BG, Harbord, RM, Zacho, J, Frayling, TM, Tybjærg-Hansen, A, Smith, GD & Smith, GD 2011, 'C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization', International Journal of Obesity, bind 35, nr. 2, s. 300-8. https://doi.org/10.1038/ijo.2010.137, https://doi.org/10.1038/ijo.2010.137

APA

Timpson, N. J., Nordestgaard, B. G., Harbord, R. M., Zacho, J., Frayling, T. M., Tybjærg-Hansen, A., Smith, G. D., & Smith, G. D. (2011). C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. International Journal of Obesity, 35(2), 300-8. https://doi.org/10.1038/ijo.2010.137, https://doi.org/10.1038/ijo.2010.137

Vancouver

Timpson NJ, Nordestgaard BG, Harbord RM, Zacho J, Frayling TM, Tybjærg-Hansen A o.a. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. International Journal of Obesity. 2011 feb. 1;35(2):300-8. https://doi.org/10.1038/ijo.2010.137, https://doi.org/10.1038/ijo.2010.137

Author

Timpson, N J ; Nordestgaard, B G ; Harbord, R M ; Zacho, J ; Frayling, T M ; Tybjærg-Hansen, Anne ; Smith, G D ; Smith, G Davey. / C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. I: International Journal of Obesity. 2011 ; Bind 35, Nr. 2. s. 300-8.

Bibtex

@article{b70c2fb0f7a94b25bd4509fa75324633,
title = "C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization",
abstract = "Context:The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.Objective:Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate this as a promising analytical technique.Participants and methods:The study was based on a large, cross-sectional European study from Copenhagen, Denmark. Genetic associates of BMI (FTO(rs9939609)) and circulating CRP (CRP(rs3091244)) have been used to reexamine observational associations between them.Results:Observational analyses showed a strong, positive association between circulating CRP and BMI (change in BMI for a doubling in logCRP of 1.03 kg m(-2) (95% confidence interval (95% CI): 1.00, 1.07), P",
author = "Timpson, {N J} and Nordestgaard, {B G} and Harbord, {R M} and J Zacho and Frayling, {T M} and Anne Tybj{\ae}rg-Hansen and Smith, {G D} and Smith, {G Davey}",
year = "2011",
month = feb,
day = "1",
doi = "10.1038/ijo.2010.137",
language = "English",
volume = "35",
pages = "300--8",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "nature publishing group",
number = "2",

}

RIS

TY - JOUR

T1 - C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

AU - Timpson, N J

AU - Nordestgaard, B G

AU - Harbord, R M

AU - Zacho, J

AU - Frayling, T M

AU - Tybjærg-Hansen, Anne

AU - Smith, G D

AU - Smith, G Davey

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Context:The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.Objective:Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate this as a promising analytical technique.Participants and methods:The study was based on a large, cross-sectional European study from Copenhagen, Denmark. Genetic associates of BMI (FTO(rs9939609)) and circulating CRP (CRP(rs3091244)) have been used to reexamine observational associations between them.Results:Observational analyses showed a strong, positive association between circulating CRP and BMI (change in BMI for a doubling in logCRP of 1.03 kg m(-2) (95% confidence interval (95% CI): 1.00, 1.07), P

AB - Context:The assignment of direction and causality within networks of observational associations is problematic outside randomized control trials, and the presence of a causal relationship between body mass index (BMI) and C-reactive protein (CRP) is disputed.Objective:Using reciprocal Mendelian randomization, we aim to assess the direction of causality in relationships between BMI and CRP and to demonstrate this as a promising analytical technique.Participants and methods:The study was based on a large, cross-sectional European study from Copenhagen, Denmark. Genetic associates of BMI (FTO(rs9939609)) and circulating CRP (CRP(rs3091244)) have been used to reexamine observational associations between them.Results:Observational analyses showed a strong, positive association between circulating CRP and BMI (change in BMI for a doubling in logCRP of 1.03 kg m(-2) (95% confidence interval (95% CI): 1.00, 1.07), P

U2 - 10.1038/ijo.2010.137

DO - 10.1038/ijo.2010.137

M3 - Journal article

C2 - 20714329

VL - 35

SP - 300

EP - 308

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 2

ER -

ID: 34151983