Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer
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Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer. / Allin, Kristine H; Nordestgaard, Børge G.
I: Critical Reviews in Clinical Laboratory Sciences, Bind 48, Nr. 4, 2011, s. 155-70.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer
AU - Allin, Kristine H
AU - Nordestgaard, Børge G
PY - 2011
Y1 - 2011
N2 - The aim of this review is to summarize present evidence of an association between circulating levels of C-reactive protein (CRP) and cancer risk, and to evaluate whether elevated circulating CRP levels cause cancer. Additionally, the review provides background information on the acute-phase response, chronic inflammation, the molecular biology, function and measurement of CRP, circulating levels of CRP in health and disease, the principle of Mendelian randomization, the association between circulating levels of CRP and cancer prognosis, and cancer biomarkers. In the Copenhagen General Population Study of approximately 63,500 individuals, the distribution of circulating levels of CRP was markedly skewed to the right with 97% of the participants having CRP levels3¿mg/L) had an 80% greater risk of early death compared with those with low CRP levels (3¿mg/L at diagnosis had a 1.7-fold increased risk of death from breast cancer compared to patients with CRP levels
AB - The aim of this review is to summarize present evidence of an association between circulating levels of C-reactive protein (CRP) and cancer risk, and to evaluate whether elevated circulating CRP levels cause cancer. Additionally, the review provides background information on the acute-phase response, chronic inflammation, the molecular biology, function and measurement of CRP, circulating levels of CRP in health and disease, the principle of Mendelian randomization, the association between circulating levels of CRP and cancer prognosis, and cancer biomarkers. In the Copenhagen General Population Study of approximately 63,500 individuals, the distribution of circulating levels of CRP was markedly skewed to the right with 97% of the participants having CRP levels3¿mg/L) had an 80% greater risk of early death compared with those with low CRP levels (3¿mg/L at diagnosis had a 1.7-fold increased risk of death from breast cancer compared to patients with CRP levels
U2 - http://dx.doi.org/10.3109/10408363.2011.599831
DO - http://dx.doi.org/10.3109/10408363.2011.599831
M3 - Journal article
VL - 48
SP - 155
EP - 170
JO - Critical Reviews in Clinical Laboratory Sciences
JF - Critical Reviews in Clinical Laboratory Sciences
SN - 1040-8363
IS - 4
ER -
ID: 40139097