Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis. / Klovaite, Jolanta; Nordestgaard, Børge G; Tybjærg-Hansen, Anne; Benn, Marianne.

I: American Journal of Respiratory and Critical Care Medicine, Bind 187, Nr. 3, 2013, s. 286-93.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Klovaite, J, Nordestgaard, BG, Tybjærg-Hansen, A & Benn, M 2013, 'Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis', American Journal of Respiratory and Critical Care Medicine, bind 187, nr. 3, s. 286-93. https://doi.org/10.1164/rccm.201207-1232OC

APA

Klovaite, J., Nordestgaard, B. G., Tybjærg-Hansen, A., & Benn, M. (2013). Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis. American Journal of Respiratory and Critical Care Medicine, 187(3), 286-93. https://doi.org/10.1164/rccm.201207-1232OC

Vancouver

Klovaite J, Nordestgaard BG, Tybjærg-Hansen A, Benn M. Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis. American Journal of Respiratory and Critical Care Medicine. 2013;187(3):286-93. https://doi.org/10.1164/rccm.201207-1232OC

Author

Klovaite, Jolanta ; Nordestgaard, Børge G ; Tybjærg-Hansen, Anne ; Benn, Marianne. / Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis. I: American Journal of Respiratory and Critical Care Medicine. 2013 ; Bind 187, Nr. 3. s. 286-93.

Bibtex

@article{1e837e5466734fa4bd0671ef77166387,
title = "Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis",
abstract = "RATIONALE: It is unclear whether elevated plasma fibrinogen associates with both deep venous thrombosis(DVT) and its complication pulmonary embolism(PE), and whether elevated fibrinogen is a direct cause of these disorders. OBJECTIVES: We tested the hypotheses that elevated plasma fibrinogen associate with increased risk of DVT alone, with any PE, and with PE in combination with DVT. METHODS: We studied 77,608 individuals from the Danish general population, of which 1,679 were diagnosed with DVT alone, 1,119 with any PE, and 272 were diagnosed with both PE and DVT. To test a potential causal relationship using a Mendelian randomization approach, we genotyped for FGB(rs1800790; rs4220) encoding fibrinogen beta chain. MEASUREMENTS AND MAIN RESULTS: Increasing plasma fibrinogen quintiles associated with increased risk of PE in combination with DVT(P-trend",
author = "Jolanta Klovaite and Nordestgaard, {B{\o}rge G} and Anne Tybj{\ae}rg-Hansen and Marianne Benn",
year = "2013",
doi = "10.1164/rccm.201207-1232OC",
language = "English",
volume = "187",
pages = "286--93",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "3",

}

RIS

TY - JOUR

T1 - Elevated Fibrinogen Levels Associate with Risk of Pulmonary Embolism, but not with Deep Venous Thrombosis

AU - Klovaite, Jolanta

AU - Nordestgaard, Børge G

AU - Tybjærg-Hansen, Anne

AU - Benn, Marianne

PY - 2013

Y1 - 2013

N2 - RATIONALE: It is unclear whether elevated plasma fibrinogen associates with both deep venous thrombosis(DVT) and its complication pulmonary embolism(PE), and whether elevated fibrinogen is a direct cause of these disorders. OBJECTIVES: We tested the hypotheses that elevated plasma fibrinogen associate with increased risk of DVT alone, with any PE, and with PE in combination with DVT. METHODS: We studied 77,608 individuals from the Danish general population, of which 1,679 were diagnosed with DVT alone, 1,119 with any PE, and 272 were diagnosed with both PE and DVT. To test a potential causal relationship using a Mendelian randomization approach, we genotyped for FGB(rs1800790; rs4220) encoding fibrinogen beta chain. MEASUREMENTS AND MAIN RESULTS: Increasing plasma fibrinogen quintiles associated with increased risk of PE in combination with DVT(P-trend

AB - RATIONALE: It is unclear whether elevated plasma fibrinogen associates with both deep venous thrombosis(DVT) and its complication pulmonary embolism(PE), and whether elevated fibrinogen is a direct cause of these disorders. OBJECTIVES: We tested the hypotheses that elevated plasma fibrinogen associate with increased risk of DVT alone, with any PE, and with PE in combination with DVT. METHODS: We studied 77,608 individuals from the Danish general population, of which 1,679 were diagnosed with DVT alone, 1,119 with any PE, and 272 were diagnosed with both PE and DVT. To test a potential causal relationship using a Mendelian randomization approach, we genotyped for FGB(rs1800790; rs4220) encoding fibrinogen beta chain. MEASUREMENTS AND MAIN RESULTS: Increasing plasma fibrinogen quintiles associated with increased risk of PE in combination with DVT(P-trend

U2 - 10.1164/rccm.201207-1232OC

DO - 10.1164/rccm.201207-1232OC

M3 - Journal article

C2 - 23220916

VL - 187

SP - 286

EP - 293

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 3

ER -

ID: 48541922