Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
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- Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia
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Genome-wide association studies (GWAS) have advanced our understanding of susceptibility to B-cell precursor acute lymphoblastic leukemia (BCP-ALL); however, much of the heritable risk remains unidentified. Here, we perform a GWAS and conduct a meta-analysis with two existing GWAS, totaling 2442 cases and 14,609 controls. We identify risk loci for BCP-ALL at 8q24.21 (rs28665337, P = 3.86 × 10-9, odds ratio (OR) = 1.34) and for ETV6-RUNX1 fusion-positive BCP-ALL at 2q22.3 (rs17481869, P = 3.20 × 10-8, OR = 2.14). Our findings provide further insights into genetic susceptibility to ALL and its biology.
Originalsprog | Engelsk |
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Artikelnummer | 1340 |
Tidsskrift | Nature Communications |
Vol/bind | 9 |
Udgave nummer | 1 |
Antal sider | 14 |
ISSN | 2041-1723 |
DOI | |
Status | Udgivet - 2018 |
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ID: 201228911