Height, selected genetic markers and prostate cancer risk: Results from the PRACTICAL consortium
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- Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium
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Background:Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer.Methods:We analysed data from the PRACTICAL consortium consisting of 6207 prostate cancer cases and 6016 controls and a subset of high grade cases (2480 cases). We explored height, polymorphisms in genes related to growth processes as main effects and their possible interactions.Results:The results suggest that height is associated with high-grade prostate cancer risk. Men with height >180 cm are at a 22% increased risk as compared to men with height <173 cm (OR 1.22, 95% CI 1.01-1.48). Genetic variants in the growth pathway gene showed an association with prostate cancer risk. The aggregate scores of the selected variants identified a significantly increased risk of overall prostate cancer and high-grade prostate cancer by 13% and 15%, respectively, in the highest score group as compared to lowest score group.Conclusions:There was no evidence of gene-environment interaction between height and the selected candidate SNPs.Our findings suggest a role of height in high-grade prostate cancer. The effect of genetic variants in the genes related to growth is seen in all cases and high-grade prostate cancer. There is no interaction between these two exposures.
Originalsprog | Engelsk |
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Tidsskrift | British Journal of Cancer |
Vol/bind | 117 |
Udgave nummer | 5 |
Sider (fra-til) | 734-743 |
Antal sider | 10 |
ISSN | 0007-0920 |
DOI | |
Status | Udgivet - 2017 |
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ID: 192110187