TY - JOUR

T1 - Plasma levels of apolipoprotein E and risk of ischemic heart disease in the general population

AU - Rasmussen, Katrine L.

AU - Tybjærg-Hansen, Anne

AU - Nordestgaard, Børge G

AU - Frikke-Schmidt, Ruth

N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

PY - 2016/3

Y1 - 2016/3

N2 - BACKGROUND AND AIMS: Triglyceride-rich lipoproteins are causally associated with high risk of ischemic heart disease (IHD), and apolipoprotein E (apoE) has a central role in their plasma clearance. While both quantitative and qualitative changes of apoE are established causes of rare dyslipidemia syndromes, it remains unclear whether plasma levels of apoE are associated with risk of IHD in the general population.METHODS: We tested whether plasma levels of apoE at enrollment were associated with future risk of IHD and myocardial infarction (MI) in 91,695 individuals from the general population.RESULTS: Multifactorially adjusted hazard ratios (HRs) for highest versus lowest apoE tertile were 1.15 (1.04-1.27) for IHD and 1.16 (1.00-1.36) for MI in men, and 0.94 (0.84-1.05) and 1.04 (0.85-1.26) in women. These associations were attenuated by adjustments for triglyceride levels. Corresponding HRs for highest versus lowest apoE tertile in ε33 carriers were 1.18 (1.03-1.36) for IHD and 1.21 (0.98-1.49) for MI in men, and 0.91 (0.78-1.06) and 0.93 (0.71-1.21) in women. Thus, the present associations were independent of APOE genotype.CONCLUSION: These findings suggest that high plasma levels of apoE are associated with IHD in men but not in women. Triglyceride-rich lipoproteins may partly explain these associations.

AB - BACKGROUND AND AIMS: Triglyceride-rich lipoproteins are causally associated with high risk of ischemic heart disease (IHD), and apolipoprotein E (apoE) has a central role in their plasma clearance. While both quantitative and qualitative changes of apoE are established causes of rare dyslipidemia syndromes, it remains unclear whether plasma levels of apoE are associated with risk of IHD in the general population.METHODS: We tested whether plasma levels of apoE at enrollment were associated with future risk of IHD and myocardial infarction (MI) in 91,695 individuals from the general population.RESULTS: Multifactorially adjusted hazard ratios (HRs) for highest versus lowest apoE tertile were 1.15 (1.04-1.27) for IHD and 1.16 (1.00-1.36) for MI in men, and 0.94 (0.84-1.05) and 1.04 (0.85-1.26) in women. These associations were attenuated by adjustments for triglyceride levels. Corresponding HRs for highest versus lowest apoE tertile in ε33 carriers were 1.18 (1.03-1.36) for IHD and 1.21 (0.98-1.49) for MI in men, and 0.91 (0.78-1.06) and 0.93 (0.71-1.21) in women. Thus, the present associations were independent of APOE genotype.CONCLUSION: These findings suggest that high plasma levels of apoE are associated with IHD in men but not in women. Triglyceride-rich lipoproteins may partly explain these associations.

KW - Aged

KW - Apolipoproteins E

KW - Biomarkers

KW - Chi-Square Distribution

KW - Denmark

KW - Female

KW - Genotype

KW - Humans

KW - Kaplan-Meier Estimate

KW - Linear Models

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Myocardial Infarction

KW - Myocardial Ischemia

KW - Phenotype

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Time Factors

KW - Triglycerides

U2 - 10.1016/j.atherosclerosis.2015.12.038

DO - 10.1016/j.atherosclerosis.2015.12.038

M3 - Journal article

C2 - 26761769

VL - 246

SP - 63

EP - 70

JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

ER -