P-wave duration and the risk of atrial fibrillation

P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

P-wave duration and the risk of atrial fibrillation : Results from the Copenhagen ECG Study. / Nielsen, Jonas B; Kühl, Jørgen T; Pietersen, Adrian; Graff, Claus; Lind, Bent; Struijk, Johannes J; Olesen, Morten S; Sinner, Moritz F; Bachmann, Troels N; Haunsø, Stig; Nordestgaard, Børge G; Ellinor, Patrick T; Svendsen, Jesper H; Kofoed, Klaus F; Køber, Lars; Holst, Anders G.

I: Heart rhythm : the official journal of the Heart Rhythm Society, Bind 12, Nr. 9, 09.2015, s. 1887-95.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nielsen, JB, Kühl, JT, Pietersen, A, Graff, C, Lind, B, Struijk, JJ, Olesen, MS, Sinner, MF, Bachmann, TN, Haunsø, S, Nordestgaard, BG, Ellinor, PT, Svendsen, JH, Kofoed, KF, Køber, L & Holst, AG 2015, 'P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study', Heart rhythm : the official journal of the Heart Rhythm Society, bind 12, nr. 9, s. 1887-95. https://doi.org/10.1016/j.hrthm.2015.04.026

APA

Nielsen, J. B., Kühl, J. T., Pietersen, A., Graff, C., Lind, B., Struijk, J. J., Olesen, M. S., Sinner, M. F., Bachmann, T. N., Haunsø, S., Nordestgaard, B. G., Ellinor, P. T., Svendsen, J. H., Kofoed, K. F., Køber, L., & Holst, A. G. (2015). P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study. Heart rhythm : the official journal of the Heart Rhythm Society, 12(9), 1887-95. https://doi.org/10.1016/j.hrthm.2015.04.026

Vancouver

Nielsen JB, Kühl JT, Pietersen A, Graff C, Lind B, Struijk JJ o.a. P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study. Heart rhythm : the official journal of the Heart Rhythm Society. 2015 sep.;12(9):1887-95. https://doi.org/10.1016/j.hrthm.2015.04.026

Author

Nielsen, Jonas B ; Kühl, Jørgen T ; Pietersen, Adrian ; Graff, Claus ; Lind, Bent ; Struijk, Johannes J ; Olesen, Morten S ; Sinner, Moritz F ; Bachmann, Troels N ; Haunsø, Stig ; Nordestgaard, Børge G ; Ellinor, Patrick T ; Svendsen, Jesper H ; Kofoed, Klaus F ; Køber, Lars ; Holst, Anders G. / P-wave duration and the risk of atrial fibrillation : Results from the Copenhagen ECG Study. I: Heart rhythm : the official journal of the Heart Rhythm Society. 2015 ; Bind 12, Nr. 9. s. 1887-95.

Bibtex

@article{b0cbd424bc4d4506bb84532001acc586,

title = "P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study",

abstract = "BACKGROUND: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.",

keywords = "Adult, Aged, Atrial Fibrillation, Brain Ischemia, Denmark, Electrocardiography, Female, Follow-Up Studies, Humans, Incidence, Male, Middle Aged, Registries, Risk Assessment, Risk Factors, Survival Rate, Time Factors, Tomography, X-Ray Computed",

author = "Nielsen, {Jonas B} and K{\"u}hl, {J{\o}rgen T} and Adrian Pietersen and Claus Graff and Bent Lind and Struijk, {Johannes J} and Olesen, {Morten S} and Sinner, {Moritz F} and Bachmann, {Troels N} and Stig Hauns{\o} and Nordestgaard, {B{\o}rge G} and Ellinor, {Patrick T} and Svendsen, {Jesper H} and Kofoed, {Klaus F} and Lars K{\o}ber and Holst, {Anders G}",

year = "2015",

month = sep,

doi = "10.1016/j.hrthm.2015.04.026",

language = "English",

volume = "12",

pages = "1887--95",

journal = "Heart Rhythm",

issn = "1547-5271",

publisher = "Elsevier",

number = "9",

}

RIS

TY - JOUR

T1 - P-wave duration and the risk of atrial fibrillation

T2 - Results from the Copenhagen ECG Study

AU - Nielsen, Jonas B

AU - Kühl, Jørgen T

AU - Pietersen, Adrian

AU - Graff, Claus

AU - Lind, Bent

AU - Struijk, Johannes J

AU - Olesen, Morten S

AU - Sinner, Moritz F

AU - Bachmann, Troels N

AU - Haunsø, Stig

AU - Nordestgaard, Børge G

AU - Ellinor, Patrick T

AU - Svendsen, Jesper H

AU - Kofoed, Klaus F

AU - Køber, Lars

AU - Holst, Anders G

PY - 2015/9

Y1 - 2015/9

N2 - BACKGROUND: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.

AB - BACKGROUND: Results on the association between P-wave duration and the risk of atrial fibrillation (AF) are conflicting.OBJECTIVE: The purpose of this study was to obtain a detailed description of the relationship between P-wave duration and the risk of AF.METHODS: Using computerized analysis of electrocardiograms from a large primary care population, we evaluated the association between P-wave duration and the risk of AF. Secondary end-points were death from cardiovascular causes and putative ischemic stroke. Data on drug use, comorbidity, and outcomes were collected from administrative registries.RESULTS: A total of 285,933 individuals were included. During median follow-up period of 6.7 years, 9550 developed AF, 9371 died of a cardiovascular cause, and 8980 had a stroke. Compared with the reference group (100-105 ms), individuals with very short (≤89 ms; hazard ratio [HR] 1.60, 95% confidence interval [CI] 1.41-1.81), intermediate (112-119 ms; HR 1.22, 95% CI 1.13-1.31), long (120-129 ms; HR 1.50, 95% CI 1.39-1.62), and very long P-wave duration (≥130 ms; HR 2.06, 95% CI 1.89-2.23) had an increased risk of incident AF. With respect to death from cardiovascular causes, we found an increased risk for very short (≤89 ms; HR 1.20, 95% CI 1.06-1.34), long (120-129 ms; HR 1.11, 95% CI 1.04-1.19), and very long P-wave duration (≥130 ms; HR 1.30, 95% CI 1.21-1.40) compared with the reference group (106-111 ms). Similar but weaker associations were found between P-wave duration and the risk of putative ischemic stroke.CONCLUSION: In a large primary care population we found both short and long P-wave duration to be robustly associated with an increased risk of AF.

KW - Adult

KW - Aged

KW - Atrial Fibrillation

KW - Brain Ischemia

KW - Denmark

KW - Electrocardiography

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Survival Rate

KW - Time Factors

KW - Tomography, X-Ray Computed

U2 - 10.1016/j.hrthm.2015.04.026

DO - 10.1016/j.hrthm.2015.04.026

M3 - Journal article

C2 - 25916567

VL - 12

SP - 1887

EP - 1895

JO - Heart Rhythm

JF - Heart Rhythm

SN - 1547-5271

IS - 9

ER -

ID: 162117526

Institut for Klinisk Medicin