Scavenger receptor AI/II truncation, lung function and COPD: a large population-based study
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Scavenger receptor AI/II truncation, lung function and COPD : a large population-based study. / Thomsen, M; Nordestgaard, B G; Tybjaerg-Hansen, A; Dahl, M; Dahl, Morten.
I: Journal of Internal Medicine, Bind 269, Nr. 3, 2011, s. 340-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Scavenger receptor AI/II truncation, lung function and COPD
T2 - a large population-based study
AU - Thomsen, M
AU - Nordestgaard, B G
AU - Tybjaerg-Hansen, A
AU - Dahl, M
AU - Dahl, Morten
N1 - © 2010 The Association for the Publication of the Journal of Internal Medicine.
PY - 2011
Y1 - 2011
N2 - The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary disease (COPD) in the general population.
AB - The scavenger receptor A-I/II (SRA-I/II) on alveolar macrophages is involved in recognition and clearance of modified lipids and inhaled particulates. A rare variant of the SRA-I/II gene, Arg293X, truncates the distal collagen-like domain, which is essential for ligand recognition. We tested whether the Arg293X variant is associated with reduced lung function and risk of chronic obstructive pulmonary disease (COPD) in the general population.
KW - Adult
KW - Aged
KW - Cohort Studies
KW - Denmark
KW - Female
KW - Forced Expiratory Volume
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Heterozygote
KW - Humans
KW - Lung
KW - Male
KW - Middle Aged
KW - Pulmonary Disease, Chronic Obstructive
KW - Scavenger Receptors, Class A
KW - Sex Factors
KW - Vital Capacity
U2 - 10.1111/j.1365-2796.2010.02308.x
DO - 10.1111/j.1365-2796.2010.02308.x
M3 - Journal article
C2 - 21077973
VL - 269
SP - 340
EP - 348
JO - Acta Medica Scandinavica
JF - Acta Medica Scandinavica
SN - 0955-7873
IS - 3
ER -
ID: 43958698