Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life
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Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life. / Nielsen, Sofie Taageby; Lytsen, Rikke Mohr; Strandkjær, Nina; Rasmussen, Ida Juul; Sillesen, Anne Sophie; B. Vøgg, R. Ottilia; Raja, Anna Axelsson; Nordestgaard, Børge G.; Kamstrup, Pia R.; Iversen, Kasper; Bundgaard, Henning; Tybjærg-Hansen, Anne; Frikke-Schmidt, Ruth.
I: European Heart Journal, Bind 44, Nr. 42, 2023, s. 4408-4418.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Significance of lipids, lipoproteins, and apolipoproteins during the first 14–16 months of life
AU - Nielsen, Sofie Taageby
AU - Lytsen, Rikke Mohr
AU - Strandkjær, Nina
AU - Rasmussen, Ida Juul
AU - Sillesen, Anne Sophie
AU - B. Vøgg, R. Ottilia
AU - Raja, Anna Axelsson
AU - Nordestgaard, Børge G.
AU - Kamstrup, Pia R.
AU - Iversen, Kasper
AU - Bundgaard, Henning
AU - Tybjærg-Hansen, Anne
AU - Frikke-Schmidt, Ruth
N1 - Publisher Copyright: © The Author(s) 2023. Published by Oxford University Press on behalf of the European Society of Cardiology.
PY - 2023
Y1 - 2023
N2 - Background and The aims of this study were to investigate lipid parameters during the first 14–16 months of life, to identify influential factors, Aims and to test whether high concentrations at birth predict high concentrations at 2- and 14–16 months. Methods The Copenhagen Baby Heart Study, including 13,354 umbilical cord blood samples and parallel venous blood samples from children and parents at birth (n = 444), 2 months (n = 364), and 14–16 months (n = 168), was used. Results Concentrations of lipids, lipoproteins, and apolipoproteins in umbilical cord blood samples correlated highly with venous blood samples from newborns. Concentrations of low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, apolipoprotein B, and lipoprotein(a) increased stepwise from birth to 2 months to 14–16 months. Linear mixed models showed that concentrations of LDL cholesterol, non-HDL cholesterol, and lipoprotein(a) above the 80th percentile at birth were associated with significantly higher concentrations at 2 and 14–16 months. Finally, lipid concentrations differed according to sex, gestational age, birth weight, breastfeeding, and parental lipid concentrations. Conclusions Lipid parameters changed during the first 14–16 months of life, and sex, gestational age, birth weight, breastfeeding, and high parental concentrations influenced concentrations. Children with high concentrations of atherogenic lipid traits at birth had higher concentrations at 2 and 14–16 months. These findings increase our knowledge of how lipid traits develop over the first 14–16 months of life and may help in deciding the optimal child age for universal familial hypercholesterolaemia screening.
AB - Background and The aims of this study were to investigate lipid parameters during the first 14–16 months of life, to identify influential factors, Aims and to test whether high concentrations at birth predict high concentrations at 2- and 14–16 months. Methods The Copenhagen Baby Heart Study, including 13,354 umbilical cord blood samples and parallel venous blood samples from children and parents at birth (n = 444), 2 months (n = 364), and 14–16 months (n = 168), was used. Results Concentrations of lipids, lipoproteins, and apolipoproteins in umbilical cord blood samples correlated highly with venous blood samples from newborns. Concentrations of low-density lipoprotein (LDL) cholesterol, non-high-density lipoprotein (HDL) cholesterol, apolipoprotein B, and lipoprotein(a) increased stepwise from birth to 2 months to 14–16 months. Linear mixed models showed that concentrations of LDL cholesterol, non-HDL cholesterol, and lipoprotein(a) above the 80th percentile at birth were associated with significantly higher concentrations at 2 and 14–16 months. Finally, lipid concentrations differed according to sex, gestational age, birth weight, breastfeeding, and parental lipid concentrations. Conclusions Lipid parameters changed during the first 14–16 months of life, and sex, gestational age, birth weight, breastfeeding, and high parental concentrations influenced concentrations. Children with high concentrations of atherogenic lipid traits at birth had higher concentrations at 2 and 14–16 months. These findings increase our knowledge of how lipid traits develop over the first 14–16 months of life and may help in deciding the optimal child age for universal familial hypercholesterolaemia screening.
KW - Apolipoproteins
KW - Lipids
KW - Lipoproteins
KW - Prevention
KW - Umbilical cord blood
U2 - 10.1093/eurheartj/ehad547
DO - 10.1093/eurheartj/ehad547
M3 - Journal article
C2 - 37632410
AN - SCOPUS:85178288812
VL - 44
SP - 4408
EP - 4418
JO - European Heart Journal
JF - European Heart Journal
SN - 0195-668X
IS - 42
ER -
ID: 376413205