A state of acquired IL-10 deficiency in 0.4% of Danish blood donors

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Standard

A state of acquired IL-10 deficiency in 0.4% of Danish blood donors. / de Lemos Rieper, Carina; Galle, Pia; Pedersen, Bente Klarlund; Hansen, Morten Bagge.

I: Cytokine, Bind 51, Nr. 3, 01.09.2010, s. 286-93.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

de Lemos Rieper, C, Galle, P, Pedersen, BK & Hansen, MB 2010, 'A state of acquired IL-10 deficiency in 0.4% of Danish blood donors', Cytokine, bind 51, nr. 3, s. 286-93. https://doi.org/10.1016/j.cyto.2010.06.009

APA

de Lemos Rieper, C., Galle, P., Pedersen, B. K., & Hansen, M. B. (2010). A state of acquired IL-10 deficiency in 0.4% of Danish blood donors. Cytokine, 51(3), 286-93. https://doi.org/10.1016/j.cyto.2010.06.009

Vancouver

de Lemos Rieper C, Galle P, Pedersen BK, Hansen MB. A state of acquired IL-10 deficiency in 0.4% of Danish blood donors. Cytokine. 2010 sep. 1;51(3):286-93. https://doi.org/10.1016/j.cyto.2010.06.009

Author

de Lemos Rieper, Carina ; Galle, Pia ; Pedersen, Bente Klarlund ; Hansen, Morten Bagge. / A state of acquired IL-10 deficiency in 0.4% of Danish blood donors. I: Cytokine. 2010 ; Bind 51, Nr. 3. s. 286-93.

Bibtex

@article{c5dbfa6f781340e2924aa04fe727a17b,
title = "A state of acquired IL-10 deficiency in 0.4% of Danish blood donors",
abstract = "Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies were of IgG class, polyclonally derived and acted as competitive IL-10 inhibitors in vitro, substantially inhibiting cellular IL-10 receptor binding and neutralizing IL-10 activity in vitro. The antibodies failed to bind viral forms of IL-10 or other members of the human IL-10 family (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, IL-29). The production of anti-IL-10 antibodies was stable from months to years, and high positive donors were likely to acquire a state of IL-10 deficiency in the circulation during this period. Anti-IL-10 antibodies were readily measurable even in highly diluted plasma samples, providing the explanation for the fact that relatively low antibody activity can be detected in normal human pooled IgG, derived from the plasma of over 1000 blood donors.",
keywords = "Antibodies, Antibody Affinity, Antibody Formation, Antibody Specificity, Blood Donors, C-Reactive Protein, Denmark, Humans, Inflammation Mediators, Interleukin-10, Receptors, Immunologic",
author = "{de Lemos Rieper}, Carina and Pia Galle and Pedersen, {Bente Klarlund} and Hansen, {Morten Bagge}",
note = "Copyright 2010. Published by Elsevier Ltd.",
year = "2010",
month = sep,
day = "1",
doi = "10.1016/j.cyto.2010.06.009",
language = "English",
volume = "51",
pages = "286--93",
journal = "Cytokine",
issn = "1043-4666",
publisher = "Academic Press",
number = "3",

}

RIS

TY - JOUR

T1 - A state of acquired IL-10 deficiency in 0.4% of Danish blood donors

AU - de Lemos Rieper, Carina

AU - Galle, Pia

AU - Pedersen, Bente Klarlund

AU - Hansen, Morten Bagge

N1 - Copyright 2010. Published by Elsevier Ltd.

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies were of IgG class, polyclonally derived and acted as competitive IL-10 inhibitors in vitro, substantially inhibiting cellular IL-10 receptor binding and neutralizing IL-10 activity in vitro. The antibodies failed to bind viral forms of IL-10 or other members of the human IL-10 family (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, IL-29). The production of anti-IL-10 antibodies was stable from months to years, and high positive donors were likely to acquire a state of IL-10 deficiency in the circulation during this period. Anti-IL-10 antibodies were readily measurable even in highly diluted plasma samples, providing the explanation for the fact that relatively low antibody activity can be detected in normal human pooled IgG, derived from the plasma of over 1000 blood donors.

AB - Autoantibodies against a variety of growth factors and cytokines are present in preparations of pooled normal human IgG, such as IVIg. The present study demonstrated that healthy Danish blood donors produced high concentrations of anti-IL-10 IgG antibodies that bound IL-10 with extremely high avidity. The antibodies were of IgG class, polyclonally derived and acted as competitive IL-10 inhibitors in vitro, substantially inhibiting cellular IL-10 receptor binding and neutralizing IL-10 activity in vitro. The antibodies failed to bind viral forms of IL-10 or other members of the human IL-10 family (IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, IL-29). The production of anti-IL-10 antibodies was stable from months to years, and high positive donors were likely to acquire a state of IL-10 deficiency in the circulation during this period. Anti-IL-10 antibodies were readily measurable even in highly diluted plasma samples, providing the explanation for the fact that relatively low antibody activity can be detected in normal human pooled IgG, derived from the plasma of over 1000 blood donors.

KW - Antibodies

KW - Antibody Affinity

KW - Antibody Formation

KW - Antibody Specificity

KW - Blood Donors

KW - C-Reactive Protein

KW - Denmark

KW - Humans

KW - Inflammation Mediators

KW - Interleukin-10

KW - Receptors, Immunologic

U2 - 10.1016/j.cyto.2010.06.009

DO - 10.1016/j.cyto.2010.06.009

M3 - Journal article

C2 - 20638860

VL - 51

SP - 286

EP - 293

JO - Cytokine

JF - Cytokine

SN - 1043-4666

IS - 3

ER -

ID: 33871431