Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells

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Standard

Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. / Larsen, R.; Sandhu, N.; Heegaard, N. H.H.; Ullum, H.; von Stemann, J. H.; Sørensen, E.; Nellemann, D. S.; Hansen, M. B.

I: Vox Sanguinis, Bind 113, Nr. 1, 2018, s. 76-79.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Larsen, R, Sandhu, N, Heegaard, NHH, Ullum, H, von Stemann, JH, Sørensen, E, Nellemann, DS & Hansen, MB 2018, 'Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells', Vox Sanguinis, bind 113, nr. 1, s. 76-79. https://doi.org/10.1111/vox.12607

APA

Larsen, R., Sandhu, N., Heegaard, N. H. H., Ullum, H., von Stemann, J. H., Sørensen, E., Nellemann, D. S., & Hansen, M. B. (2018). Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. Vox Sanguinis, 113(1), 76-79. https://doi.org/10.1111/vox.12607

Vancouver

Larsen R, Sandhu N, Heegaard NHH, Ullum H, von Stemann JH, Sørensen E o.a. Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. Vox Sanguinis. 2018;113(1):76-79. https://doi.org/10.1111/vox.12607

Author

Larsen, R. ; Sandhu, N. ; Heegaard, N. H.H. ; Ullum, H. ; von Stemann, J. H. ; Sørensen, E. ; Nellemann, D. S. ; Hansen, M. B. / Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells. I: Vox Sanguinis. 2018 ; Bind 113, Nr. 1. s. 76-79.

Bibtex

@article{d952b6fae9ce45f0a1b7c28402057ddc,
title = "Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells",
abstract = "It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.",
keywords = "cytokine, leucodepletion, red cell components, transfusion medicine (in general), transfusion reactions",
author = "R. Larsen and N. Sandhu and Heegaard, {N. H.H.} and H. Ullum and {von Stemann}, {J. H.} and E. S{\o}rensen and Nellemann, {D. S.} and Hansen, {M. B.}",
year = "2018",
doi = "10.1111/vox.12607",
language = "English",
volume = "113",
pages = "76--79",
journal = "Vox Sanguinis",
issn = "0042-9007",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Changes in circulating inflammatory markers following febrile non-haemolytic transfusion reactions to leucoreduced red cells

AU - Larsen, R.

AU - Sandhu, N.

AU - Heegaard, N. H.H.

AU - Ullum, H.

AU - von Stemann, J. H.

AU - Sørensen, E.

AU - Nellemann, D. S.

AU - Hansen, M. B.

PY - 2018

Y1 - 2018

N2 - It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.

AB - It would be desirable to be able to distinguish fever as a result of febrile non-haemolytic transfusion reactions (FNHTR) from other febrile conditions. To further characterize the inflammatory feature of FNHTR, we measured a large panel of inflammatory markers in pre- and posttransfusion plasma samples from patients with and without FNHTR following the transfusion of leucoreduced red blood cells. As FNHTR patients only displayed a significant increase in IL-6, we conclude that changes in plasma cytokine levels during FNHTR are unlikely to be used diagnostically. An incidental finding of a distinct cytokine pattern in pretransfusion samples from FNHTR patients warrants further investigations, as it might be used to characterize the nature of FNHTR and to predict the risk of these adverse events.

KW - cytokine

KW - leucodepletion

KW - red cell components

KW - transfusion medicine (in general)

KW - transfusion reactions

U2 - 10.1111/vox.12607

DO - 10.1111/vox.12607

M3 - Journal article

C2 - 29023768

AN - SCOPUS:85031101490

VL - 113

SP - 76

EP - 79

JO - Vox Sanguinis

JF - Vox Sanguinis

SN - 0042-9007

IS - 1

ER -

ID: 189450374