Cytokines and autoantibodies to cytokines

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Cytokines and autoantibodies to cytokines. / Bendtzen, Klaus; Hansen, Morten B.; Ross, Christian; Poulsen, Lars K.; Svenson, Morten.

I: Stem Cells, Bind 13, Nr. 3, 1995, s. 206-222.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bendtzen, K, Hansen, MB, Ross, C, Poulsen, LK & Svenson, M 1995, 'Cytokines and autoantibodies to cytokines', Stem Cells, bind 13, nr. 3, s. 206-222. https://doi.org/10.1002/stem.5530130303

APA

Bendtzen, K., Hansen, M. B., Ross, C., Poulsen, L. K., & Svenson, M. (1995). Cytokines and autoantibodies to cytokines. Stem Cells, 13(3), 206-222. https://doi.org/10.1002/stem.5530130303

Vancouver

Bendtzen K, Hansen MB, Ross C, Poulsen LK, Svenson M. Cytokines and autoantibodies to cytokines. Stem Cells. 1995;13(3):206-222. https://doi.org/10.1002/stem.5530130303

Author

Bendtzen, Klaus ; Hansen, Morten B. ; Ross, Christian ; Poulsen, Lars K. ; Svenson, Morten. / Cytokines and autoantibodies to cytokines. I: Stem Cells. 1995 ; Bind 13, Nr. 3. s. 206-222.

Bibtex

@article{a342d1cf7e90470ca3dc8be1c47166f2,
title = "Cytokines and autoantibodies to cytokines",
abstract = "Cytokines are essential components of our defense and repair systems but also potentially harmful mediators of infectious and immunoinflammatory reactions. Clinically important cytokines function systemically as pleiotropic hormones with overlapping effects on many cell types. All engage in a complex network of agonists and antagonists. Some immunoglobulin G (IgG) antibodies have been found to be potent and specific regulators of cytokines. These antibodies bind interleukin (IL‐1)α, IL‐6, IL‐10, leukemia inhibitory factor (LIF), and interferon (IFN)‐α/β with exceptional force. They neutralize their corresponding cytokines ex vivo and perhaps in vivo, although they may also function as cytokine carriers. The biological role of autoantibodies to cytokines is not yet understood, but they may provide a level of regulation not appreciated at present. Inappropriate production/function of such antibodies could be pathogenetically involved in immunoinflammatory and other diseases. Cytokine antibodies may also contribute to the anti‐inflammatory effects of human IgG therapy.",
keywords = "Autoantibody, IFN‐α, IL‐10, IL‐1α, IL‐6, Interferons, Interleukins, LIF, Natural regulation, Review",
author = "Klaus Bendtzen and Hansen, {Morten B.} and Christian Ross and Poulsen, {Lars K.} and Morten Svenson",
year = "1995",
doi = "10.1002/stem.5530130303",
language = "English",
volume = "13",
pages = "206--222",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press, Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Cytokines and autoantibodies to cytokines

AU - Bendtzen, Klaus

AU - Hansen, Morten B.

AU - Ross, Christian

AU - Poulsen, Lars K.

AU - Svenson, Morten

PY - 1995

Y1 - 1995

N2 - Cytokines are essential components of our defense and repair systems but also potentially harmful mediators of infectious and immunoinflammatory reactions. Clinically important cytokines function systemically as pleiotropic hormones with overlapping effects on many cell types. All engage in a complex network of agonists and antagonists. Some immunoglobulin G (IgG) antibodies have been found to be potent and specific regulators of cytokines. These antibodies bind interleukin (IL‐1)α, IL‐6, IL‐10, leukemia inhibitory factor (LIF), and interferon (IFN)‐α/β with exceptional force. They neutralize their corresponding cytokines ex vivo and perhaps in vivo, although they may also function as cytokine carriers. The biological role of autoantibodies to cytokines is not yet understood, but they may provide a level of regulation not appreciated at present. Inappropriate production/function of such antibodies could be pathogenetically involved in immunoinflammatory and other diseases. Cytokine antibodies may also contribute to the anti‐inflammatory effects of human IgG therapy.

AB - Cytokines are essential components of our defense and repair systems but also potentially harmful mediators of infectious and immunoinflammatory reactions. Clinically important cytokines function systemically as pleiotropic hormones with overlapping effects on many cell types. All engage in a complex network of agonists and antagonists. Some immunoglobulin G (IgG) antibodies have been found to be potent and specific regulators of cytokines. These antibodies bind interleukin (IL‐1)α, IL‐6, IL‐10, leukemia inhibitory factor (LIF), and interferon (IFN)‐α/β with exceptional force. They neutralize their corresponding cytokines ex vivo and perhaps in vivo, although they may also function as cytokine carriers. The biological role of autoantibodies to cytokines is not yet understood, but they may provide a level of regulation not appreciated at present. Inappropriate production/function of such antibodies could be pathogenetically involved in immunoinflammatory and other diseases. Cytokine antibodies may also contribute to the anti‐inflammatory effects of human IgG therapy.

KW - Autoantibody

KW - IFN‐α

KW - IL‐10

KW - IL‐1α

KW - IL‐6

KW - Interferons

KW - Interleukins

KW - LIF

KW - Natural regulation

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=0029057205&partnerID=8YFLogxK

U2 - 10.1002/stem.5530130303

DO - 10.1002/stem.5530130303

M3 - Journal article

C2 - 7613489

AN - SCOPUS:0029057205

VL - 13

SP - 206

EP - 222

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 3

ER -

ID: 328567074