Standard
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. / Sørensen, Mette G; Henriksen, Kim; Neutzsky-Wulff, Anita V; Dziegiel, Morten Hanefeld; Karsdal, Morten A.
I:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Bind 22, Nr. 10, 10.2007, s. 1640-8.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Sørensen, MG, Henriksen, K, Neutzsky-Wulff, AV
, Dziegiel, MH & Karsdal, MA 2007, '
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption',
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, bind 22, nr. 10, s. 1640-8.
https://doi.org/10.1359/jbmr.070613APA
Sørensen, M. G., Henriksen, K., Neutzsky-Wulff, A. V.
, Dziegiel, M. H., & Karsdal, M. A. (2007).
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
22(10), 1640-8.
https://doi.org/10.1359/jbmr.070613Vancouver
Sørensen MG, Henriksen K, Neutzsky-Wulff AV
, Dziegiel MH, Karsdal MA.
Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2007 okt.;22(10):1640-8.
https://doi.org/10.1359/jbmr.070613Author
Sørensen, Mette G ; Henriksen, Kim ; Neutzsky-Wulff, Anita V ; Dziegiel, Morten Hanefeld ; Karsdal, Morten A. / Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption. I: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2007 ; Bind 22, Nr. 10. s. 1640-8.
Bibtex
@article{75636f00fcfd486187a7b1e8c26e3770,
title = "Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption",
abstract = "Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.",
keywords = "Acids, Adrenal Medulla, Animals, Biological Transport, Bone Resorption, Cattle, Cell Survival, Cells, Cultured, Dioxolanes, Enzyme Inhibitors, Humans, Hydrogen-Ion Concentration, Lignans, Molecular Structure, Osteoclasts, Vacuolar Proton-Translocating ATPases",
author = "S{\o}rensen, {Mette G} and Kim Henriksen and Neutzsky-Wulff, {Anita V} and Dziegiel, {Morten Hanefeld} and Karsdal, {Morten A}",
year = "2007",
month = oct,
doi = "10.1359/jbmr.070613",
language = "English",
volume = "22",
pages = "1640--8",
journal = "Journal of Bone and Mineral Research",
issn = "0884-0431",
publisher = "Wiley-Blackwell",
number = "10",
}
RIS
TY - JOUR
T1 - Diphyllin, a novel and naturally potent V-ATPase inhibitor, abrogates acidification of the osteoclastic resorption lacunae and bone resorption
AU - Sørensen, Mette G
AU - Henriksen, Kim
AU - Neutzsky-Wulff, Anita V
AU - Dziegiel, Morten Hanefeld
AU - Karsdal, Morten A
PY - 2007/10
Y1 - 2007/10
N2 - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.
AB - Dissolution of the inorganic phase of bone by the osteoclasts mediated by V-ATPase and ClC-7 is a prerequisite for bone resorption. Inhibitors of osteoclastic V-ATPase or ClC-7 are novel approaches for inhibition of osteoclastic bone resorption. By testing natural compounds in acidification assays, diphyllin was identified. We characterized diphyllin with respect to the pharmacological effects on osteoclasts.
KW - Acids
KW - Adrenal Medulla
KW - Animals
KW - Biological Transport
KW - Bone Resorption
KW - Cattle
KW - Cell Survival
KW - Cells, Cultured
KW - Dioxolanes
KW - Enzyme Inhibitors
KW - Humans
KW - Hydrogen-Ion Concentration
KW - Lignans
KW - Molecular Structure
KW - Osteoclasts
KW - Vacuolar Proton-Translocating ATPases
U2 - 10.1359/jbmr.070613
DO - 10.1359/jbmr.070613
M3 - Journal article
C2 - 17576165
VL - 22
SP - 1640
EP - 1648
JO - Journal of Bone and Mineral Research
JF - Journal of Bone and Mineral Research
SN - 0884-0431
IS - 10
ER -
