Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark

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Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark. / Kaspersen, Kathrine Agergård; Hindhede, Lotte; Boldsen, Jens Kjærgaard; Mikkelsen, Susan; Vestergaard, Lasse Skafte; Berthelsen, Ann Sofie Nicole; Moustsen-Helms, Ida Rask; Holm, Dorte Kinggaard; Nilsson, Anna Christine; Sækmose, Susanne Gjørup; Sørensen, Erik; Harritshøj, Lene Holm; Aagaard, Bitten; Hjalgrim, Henrik; Lillevang, Søren Thue; Jørgensen, Charlotte Sværke; Krause, Tyra Grove; Ullum, Henrik; Pedersen, Ole Birger Vestager; Ostrowski, Sisse Rye; Erikstrup, Christian.

I: Journal of Infectious Diseases, Bind 225, Nr. 2, 2022, s. 219-228.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kaspersen, KA, Hindhede, L, Boldsen, JK, Mikkelsen, S, Vestergaard, LS, Berthelsen, ASN, Moustsen-Helms, IR, Holm, DK, Nilsson, AC, Sækmose, SG, Sørensen, E, Harritshøj, LH, Aagaard, B, Hjalgrim, H, Lillevang, ST, Jørgensen, CS, Krause, TG, Ullum, H, Pedersen, OBV, Ostrowski, SR & Erikstrup, C 2022, 'Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark', Journal of Infectious Diseases, bind 225, nr. 2, s. 219-228. https://doi.org/10.1093/infdis/jiab566

APA

Kaspersen, K. A., Hindhede, L., Boldsen, J. K., Mikkelsen, S., Vestergaard, L. S., Berthelsen, A. S. N., Moustsen-Helms, I. R., Holm, D. K., Nilsson, A. C., Sækmose, S. G., Sørensen, E., Harritshøj, L. H., Aagaard, B., Hjalgrim, H., Lillevang, S. T., Jørgensen, C. S., Krause, T. G., Ullum, H., Pedersen, O. B. V., ... Erikstrup, C. (2022). Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark. Journal of Infectious Diseases, 225(2), 219-228. https://doi.org/10.1093/infdis/jiab566

Vancouver

Kaspersen KA, Hindhede L, Boldsen JK, Mikkelsen S, Vestergaard LS, Berthelsen ASN o.a. Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark. Journal of Infectious Diseases. 2022;225(2):219-228. https://doi.org/10.1093/infdis/jiab566

Author

Kaspersen, Kathrine Agergård ; Hindhede, Lotte ; Boldsen, Jens Kjærgaard ; Mikkelsen, Susan ; Vestergaard, Lasse Skafte ; Berthelsen, Ann Sofie Nicole ; Moustsen-Helms, Ida Rask ; Holm, Dorte Kinggaard ; Nilsson, Anna Christine ; Sækmose, Susanne Gjørup ; Sørensen, Erik ; Harritshøj, Lene Holm ; Aagaard, Bitten ; Hjalgrim, Henrik ; Lillevang, Søren Thue ; Jørgensen, Charlotte Sværke ; Krause, Tyra Grove ; Ullum, Henrik ; Pedersen, Ole Birger Vestager ; Ostrowski, Sisse Rye ; Erikstrup, Christian. / Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark. I: Journal of Infectious Diseases. 2022 ; Bind 225, Nr. 2. s. 219-228.

Bibtex

@article{99157421aec94dd880f5c5e4e98757a8,
title = "Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark",
abstract = "Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.",
keywords = "blood donors, infection fatality rate, SARS-CoV-2, seroprevalence",
author = "Kaspersen, {Kathrine Agerg{\aa}rd} and Lotte Hindhede and Boldsen, {Jens Kj{\ae}rgaard} and Susan Mikkelsen and Vestergaard, {Lasse Skafte} and Berthelsen, {Ann Sofie Nicole} and Moustsen-Helms, {Ida Rask} and Holm, {Dorte Kinggaard} and Nilsson, {Anna Christine} and S{\ae}kmose, {Susanne Gj{\o}rup} and Erik S{\o}rensen and Harritsh{\o}j, {Lene Holm} and Bitten Aagaard and Henrik Hjalgrim and Lillevang, {S{\o}ren Thue} and J{\o}rgensen, {Charlotte Sv{\ae}rke} and Krause, {Tyra Grove} and Henrik Ullum and Pedersen, {Ole Birger Vestager} and Ostrowski, {Sisse Rye} and Christian Erikstrup",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2022",
doi = "10.1093/infdis/jiab566",
language = "English",
volume = "225",
pages = "219--228",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",

}

RIS

TY - JOUR

T1 - Estimation of SARS-CoV-2 Infection Fatality Rate by Age and Comorbidity Status Using Antibody Screening of Blood Donors during the COVID-19 Epidemic in Denmark

AU - Kaspersen, Kathrine Agergård

AU - Hindhede, Lotte

AU - Boldsen, Jens Kjærgaard

AU - Mikkelsen, Susan

AU - Vestergaard, Lasse Skafte

AU - Berthelsen, Ann Sofie Nicole

AU - Moustsen-Helms, Ida Rask

AU - Holm, Dorte Kinggaard

AU - Nilsson, Anna Christine

AU - Sækmose, Susanne Gjørup

AU - Sørensen, Erik

AU - Harritshøj, Lene Holm

AU - Aagaard, Bitten

AU - Hjalgrim, Henrik

AU - Lillevang, Søren Thue

AU - Jørgensen, Charlotte Sværke

AU - Krause, Tyra Grove

AU - Ullum, Henrik

AU - Pedersen, Ole Birger Vestager

AU - Ostrowski, Sisse Rye

AU - Erikstrup, Christian

N1 - Publisher Copyright: © 2021 The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2022

Y1 - 2022

N2 - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

AB - Background: Studies presenting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) for healthy individuals are warranted. We estimate IFR by age and comorbidity status using data from a large serosurvey among Danish blood donors and nationwide data on coronavirus disease 2019 (COVID-19) mortality. Methods: Danish blood donors aged 17-69 years donating blood October 2020-February 2021 were tested with a commercial SARS-CoV-2 total antibody assay. IFR was estimated for weeks 11 to 42, 2020 and week 43, 2020 to week 6, 2021, representing the first 2 waves of COVID-19 epidemic in Denmark. Results: In total, 84944 blood donors were tested for antibodies. The seroprevalence was 2% in October 2020 and 7% in February 2021. Among 3898039 Danish residents aged 17-69 years, 249 deaths were recorded. The IFR was low for people <51 years without comorbidity during the 2 waves (combined IFR=3.36 per 100000 infections). The IFR was below 3‰ for people aged 61-69 years without comorbidity. IFR increased with age and comorbidity but declined from the first to second wave. Conclusions: In this nationwide study, the IFR was very low among people <51 years without comorbidity.

KW - blood donors

KW - infection fatality rate

KW - SARS-CoV-2

KW - seroprevalence

U2 - 10.1093/infdis/jiab566

DO - 10.1093/infdis/jiab566

M3 - Journal article

C2 - 34788834

AN - SCOPUS:85123721812

VL - 225

SP - 219

EP - 228

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 2

ER -

ID: 321550546