Malariavacciner, en nødvendighed for fremtidig malariakontrol. Status og fremtidsudsigter
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Traditional malaria control is in a crisis on account of chemo-resistance of Plasmodium falciparum and insecticide-resistance of the malaria mosquito. New ways to control malaria have been opened by the possibility of producing a vaccine. Several malaria proteins (e.g. CSP, gp195, Pf155/RESA, GLURP) have been sequenced and it has been shown that most of the proteins have repetitive units. Analyses of T- and B-cell epitopes show that T-cell epitopes are mainly localized to the non-conserved parts of the antigens. Repeated malaria infections, therefore, may be seen as a number of primary infections, which partly explains the very slow development of immunity to the parasite. The initial three vaccination experiments in humans did not succeed in inducing a complete protection of the individual but it showed that partial immunization is possible.
Bidragets oversatte titel | Malaria vaccines, a necessity for future control of malaria. Status and future perspectives |
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Originalsprog | Dansk |
Tidsskrift | Ugeskrift for Laeger |
Vol/bind | 152 |
Udgave nummer | 29 |
Sider (fra-til) | 2092-5 |
Antal sider | 4 |
ISSN | 0041-5782 |
Status | Udgivet - 16 jul. 1990 |
- Antigens, Protozoan, Humans, Malaria, Vaccines
Forskningsområder
ID: 47557009