TY - JOUR

T1 - No association between rs6897932 in the gene encoding interleukin-7 receptor α and low-grade inflammation or self-reported health

T2 - results from the Danish Blood Donor Study

AU - Hartling, Hans J

AU - Sørensen, Cecilie J

AU - Rigas, Andreas S

AU - Burgdorf, Kristoffer S

AU - Nielsen, Susanne D.

AU - Pedersen, Ole Birger Vesterager

AU - Petersen, Mikkel S

AU - Sørensen, Erik

AU - Kotzé, Sebastian

AU - Thørner, Lise W

AU - Hjalgrim, Henrik

AU - Erikstrup, Christian

AU - Ullum, Henrik

N1 - © 2014 APMIS. Published by John Wiley & Sons Ltd.

PY - 2015/2

Y1 - 2015/2

N2 - The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. Low-grade inflammation (LGI) and self-reported, health-related quality of life (HRQL) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T-allele in rs6897932 is associated with reduced risk of LGI (hsCRP 3-10 mg/L), history of infectious mononucleosis (IM), and HRQL in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of LGI, self-reported IM, and HRQL in univariable and multivariable models stratified by sex. No associations between rs6897932 and LGI, self-reported IM or HRQL were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T-allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system.

AB - The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. Low-grade inflammation (LGI) and self-reported, health-related quality of life (HRQL) are often associated with chronic diseases and widely used in assessing and monitoring health status. The aim of the present study was to evaluate whether the T-allele in rs6897932 is associated with reduced risk of LGI (hsCRP 3-10 mg/L), history of infectious mononucleosis (IM), and HRQL in healthy individuals. A total of 17, 293 healthy Danish individuals from the Danish Blood Donor Study were included in the analyses. We tested rs6897932 as a predictor of LGI, self-reported IM, and HRQL in univariable and multivariable models stratified by sex. No associations between rs6897932 and LGI, self-reported IM or HRQL were found in men or women. This suggests that rs6897932 is not associated with general inflammation, and the reported associations between the T-allele in rs6897932 with several autoimmune diseases may be mediated through effects on a restricted part of the immune system.

KW - Adult

KW - Alleles

KW - C-Reactive Protein

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Humans

KW - Infectious Mononucleosis

KW - Inflammation

KW - Interleukin-7 Receptor alpha Subunit

KW - Male

KW - Middle Aged

KW - Polymorphism, Single Nucleotide

KW - Quality of Life

KW - Self Report

KW - Surveys and Questionnaires

U2 - 10.1111/apm.12334

DO - 10.1111/apm.12334

M3 - Journal article

C2 - 25421942

VL - 123

SP - 169

EP - 174

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 2

ER -