The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission
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The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission. / Petersen, E; Høgh, B; Dziegiel, Morten Hanefeld; Borre, M; Björkman, A; Marbiah, N T; Dolopaye, E; Hanson, A P; Jepsen, S.
I: Acta Tropica, Bind 51, Nr. 2, 06.1992, s. 135-42.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The antibody response to well-defined malaria antigens after acute malaria in individuals living under continuous malaria transmission
AU - Petersen, E
AU - Høgh, B
AU - Dziegiel, Morten Hanefeld
AU - Borre, M
AU - Björkman, A
AU - Marbiah, N T
AU - Dolopaye, E
AU - Hanson, A P
AU - Jepsen, S
PY - 1992/6
Y1 - 1992/6
N2 - The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.
AB - The IgG and IgM antibody responses to the C-terminal 783 amino acids of the P. falciparum glutamate-rich protein, GLURP489-1271, expressed as an E. coli fusion protein, the IgG response to a 18-mer synthetic peptide EDKNEKGQHEIVEVEEIL (GLURP899-916) representing the C-terminal repeats of GLURP, and a synthetic peptide (EENV)6 representing the C-terminal repeats from Pf155/RESA, were investigated longitudinally in 13 children and 7 adults living under conditions of continuous, intense malaria transmission. Some subjects did not recognize the antigens after malaria infection, and in subjects recognizing the antigens, the responses were often short-lived. In adults, the antibody responses to the GLURP489-1271 fusion protein and the (EENV)6 peptide peaked after 2 weeks, and not all individuals responded to all antigens. The antibody response, even against large fragments of conserved antigens, is not uniformly elicited by natural malaria infection in previously primed donors.
KW - Adolescent
KW - Adult
KW - Amino Acid Sequence
KW - Animals
KW - Antibodies, Protozoan
KW - Female
KW - Humans
KW - Immunoglobulin G
KW - Immunoglobulin M
KW - Malaria, Falciparum
KW - Male
KW - Molecular Sequence Data
KW - Plasmodium falciparum
KW - Protozoan Proteins
M3 - Journal article
C2 - 1354931
VL - 51
SP - 135
EP - 142
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 2
ER -
ID: 47557048