IL-6, but not TNF-α, increases plasma YKL-40 in human subjects
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Plasma levels of YKL-40 are elevated in patients with systemic infection, inflammatory disorders and cancer. Both monocytes/macrophages, neutrophils, and cancer cells have the capacity to produce YKL-40, but the regulation during the inflammatory response is unknown. To study the possible role of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-a in the regulation of YKL-40 plasma levels, we included healthy men, who received either recombinant human (rh)IL-6 (n=6), rhTNF-a (n=8) or vehicle (n=7) for 3h. The plasma levels of IL-6 and TNF-a reached ~ 150 and ~ 18 pg/ml, respectively, during the infusions. Following the IL-6 infusion, the plasma level of YKL-40 increased from ~ 30 to ~ 57 ng/ml (p
Originalsprog | Engelsk |
---|---|
Tidsskrift | Cytokine |
Vol/bind | 55 |
Udgave nummer | 1 |
Sider (fra-til) | 152-5 |
Antal sider | 4 |
ISSN | 1043-4666 |
DOI | |
Status | Udgivet - 2011 |
ID: 40166566