Neurofilament light chain levels in serum among a large mixed memory clinic cohort: Confounders and diagnostic usefulness
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INTRODUCTION: Early and accurate diagnosis of neurocognitive disorders including neurodegenerative dementia remains challenging. This study explores the impact of biological factors on serum neurofilament light chain (NfL) levels and clinical usefulness for the detection of neurocognitive disorders in a mixed memory clinic. METHODS: Serum samples and clinical data were obtained from 1188 patients who underwent diagnostic investigations for memory complaints between January 2018 and September 2019. Serum NfL was measured using single molecule array technology. RESULTS: NfL exhibited a moderate association with age, estimated glomerular filtration rate (eGFR), and Fazekas score. NfL was able to differentiate between patients with neurocognitive disorders and those without with a sensitivity and specificity of 80%. NfL could, however, not distinguish between different dementia etiologies. DISCUSSION: Serum NfL could aid early diagnostic triage by identifying patients requiring further diagnostic procedures and therefore aid in a more focused use of health-care resources.
Originalsprog | Engelsk |
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Artikelnummer | e12512 |
Tidsskrift | Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring |
Vol/bind | 15 |
Udgave nummer | 4 |
Antal sider | 9 |
ISSN | 2352-8729 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
This study was supported by The Danish Alzheimer's Research Foundation, Absalon Foundation of May 1st 1978, and Toyota‐fonden Danmark. FS holds a professorship at the Faculty of Health Sciences and Medicine, University of Copenhagen sponsored by the Danish Multiple Sclerosis Society.
Funding Information:
This study was supported by The Danish Alzheimer's Research Foundation, Absalon Foundation of May 1st 1978, and Toyota-fonden Danmark. FS holds a professorship at the Faculty of Health Sciences and Medicine, University of Copenhagen sponsored by the Danish Multiple Sclerosis Society.
Publisher Copyright:
© 2023 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
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