OxPhos defects cause hypermetabolism and reduce lifespan in cells and in patients with mitochondrial diseases
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Originalsprog | Engelsk |
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Artikelnummer | 22 |
Tidsskrift | Communications Biology |
Vol/bind | 6 |
Udgave nummer | 1 |
Antal sider | 22 |
ISSN | 2399-3642 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We are grateful to Jane Newman, Renae Stefanetti, Robert W Taylor, and Gráinne S Gorman (Wellcome Center for Mitochondrial Research) for contributing data for Cohort 2, Rohit Sharma and Vamsi Mootha (Massachusetts General Hospital) for contributing data for Cohort 4, Robert McFarland (Wellcome Center for Mitochondrial Research) for contributing data for Cohort 17, and other investigators whose work contributed to the meta-analysis in Fig. 1. We thank Marlon McGill for technical assistance with parts of this project and Herman Pontzer for analytical advice. The cellular studies and analyses were supported by NIH grant R01AG066828 and the Baszucki Brain Research Fund to M.P., the J. Willard and Alice S. Marriott Foundation, Muscular Dystrophy Association, Nicholas Nunno Foundation, JDF Fund for Mitochondrial Research, and Shuman Mitochondrial Disease Fund to M.H. Further support was provided by NIH grants R01GM123771 and R35HL155670 awarded to E.L.S. and M-P.S-O., respectively. All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIH, NHS, the NIHR, or the Department of Health.
Publisher Copyright:
© 2023, The Author(s).
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