Regional cerebral blood flow in acute experimental allergic encephalomyelitis

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Standard

Regional cerebral blood flow in acute experimental allergic encephalomyelitis. / Juhler, M; Paulson, O B.

I: Brain Research, Bind 363, Nr. 2, 22.01.1986, s. 272-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Juhler, M & Paulson, OB 1986, 'Regional cerebral blood flow in acute experimental allergic encephalomyelitis', Brain Research, bind 363, nr. 2, s. 272-8. https://doi.org/10.1016/0006-8993(86)91012-7

APA

Juhler, M., & Paulson, O. B. (1986). Regional cerebral blood flow in acute experimental allergic encephalomyelitis. Brain Research, 363(2), 272-8. https://doi.org/10.1016/0006-8993(86)91012-7

Vancouver

Juhler M, Paulson OB. Regional cerebral blood flow in acute experimental allergic encephalomyelitis. Brain Research. 1986 jan. 22;363(2):272-8. https://doi.org/10.1016/0006-8993(86)91012-7

Author

Juhler, M ; Paulson, O B. / Regional cerebral blood flow in acute experimental allergic encephalomyelitis. I: Brain Research. 1986 ; Bind 363, Nr. 2. s. 272-8.

Bibtex

@article{24fdeb530e32463bab55b4caa71c1631,
title = "Regional cerebral blood flow in acute experimental allergic encephalomyelitis",
abstract = "Regional cerebral blood flow was studied in Lewis rats with fulminant acute experimental allergic encephalomyelitis (EAE). [14C]iodoantipyrine was used as a tracer. By employing a short experimental time and an infusion schedule producing an increasing arterial tracer concentration, the spatial resolution of the method was fine enough to detect focal increases in blood flow in the small central nervous system lesions (lymphocytic accumulations). An increase of flow of 100% in the lesions and a decrease of 50% in the cerebral cortex of EAE animals was statistically significant. In all other regions studied (deep cerebral structures, cerebellum), blood flow in EAE animals did not differ from the control values. The flow increase corresponding to the lesions may be due to inflammatory hyperemia. The cortical decrease in flow may be secondary to sensory motor impairment.",
keywords = "Acute Disease, Animals, Antipyrine/analogs & derivatives, Autoradiography, Blood-Brain Barrier, Brain/blood supply, Cerebral Cortex/blood supply, Encephalomyelitis, Autoimmune, Experimental/physiopathology, Male, Rats, Rats, Inbred Lew, Regional Blood Flow, Thalamus/blood supply",
author = "M Juhler and Paulson, {O B}",
year = "1986",
month = jan,
day = "22",
doi = "10.1016/0006-8993(86)91012-7",
language = "English",
volume = "363",
pages = "272--8",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Regional cerebral blood flow in acute experimental allergic encephalomyelitis

AU - Juhler, M

AU - Paulson, O B

PY - 1986/1/22

Y1 - 1986/1/22

N2 - Regional cerebral blood flow was studied in Lewis rats with fulminant acute experimental allergic encephalomyelitis (EAE). [14C]iodoantipyrine was used as a tracer. By employing a short experimental time and an infusion schedule producing an increasing arterial tracer concentration, the spatial resolution of the method was fine enough to detect focal increases in blood flow in the small central nervous system lesions (lymphocytic accumulations). An increase of flow of 100% in the lesions and a decrease of 50% in the cerebral cortex of EAE animals was statistically significant. In all other regions studied (deep cerebral structures, cerebellum), blood flow in EAE animals did not differ from the control values. The flow increase corresponding to the lesions may be due to inflammatory hyperemia. The cortical decrease in flow may be secondary to sensory motor impairment.

AB - Regional cerebral blood flow was studied in Lewis rats with fulminant acute experimental allergic encephalomyelitis (EAE). [14C]iodoantipyrine was used as a tracer. By employing a short experimental time and an infusion schedule producing an increasing arterial tracer concentration, the spatial resolution of the method was fine enough to detect focal increases in blood flow in the small central nervous system lesions (lymphocytic accumulations). An increase of flow of 100% in the lesions and a decrease of 50% in the cerebral cortex of EAE animals was statistically significant. In all other regions studied (deep cerebral structures, cerebellum), blood flow in EAE animals did not differ from the control values. The flow increase corresponding to the lesions may be due to inflammatory hyperemia. The cortical decrease in flow may be secondary to sensory motor impairment.

KW - Acute Disease

KW - Animals

KW - Antipyrine/analogs & derivatives

KW - Autoradiography

KW - Blood-Brain Barrier

KW - Brain/blood supply

KW - Cerebral Cortex/blood supply

KW - Encephalomyelitis, Autoimmune, Experimental/physiopathology

KW - Male

KW - Rats

KW - Rats, Inbred Lew

KW - Regional Blood Flow

KW - Thalamus/blood supply

U2 - 10.1016/0006-8993(86)91012-7

DO - 10.1016/0006-8993(86)91012-7

M3 - Journal article

C2 - 3484654

VL - 363

SP - 272

EP - 278

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -

ID: 275604937