Impact of tobacco use on corneal thickness and endothelial health: a systematic review with meta-analyses
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Impact of tobacco use on corneal thickness and endothelial health : a systematic review with meta-analyses. / Frifelt, Lith Elizabeth Wienholtz; Subhi, Yousif; Holm, Lars Morten; Singh, Amardeep.
I: Acta Ophthalmologica, Bind 100, Nr. 1, 2022, s. 26-34.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Impact of tobacco use on corneal thickness and endothelial health
T2 - a systematic review with meta-analyses
AU - Frifelt, Lith Elizabeth Wienholtz
AU - Subhi, Yousif
AU - Holm, Lars Morten
AU - Singh, Amardeep
N1 - Publisher Copyright: © 2021 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd
PY - 2022
Y1 - 2022
N2 - Purpose: To investigate the impact of tobacco use on corneal thickness and corneal endothelial health. Methods: We searched the PubMed/MEDLINE, EMBASE, the Cochrane Central and all affiliated databases of the Web of Science on 20 July 2020. Two authors reviewed the studies and extracted the data in an independent fashion. Studies were reviewed qualitatively in the text, and central corneal thickness (CCT) and corneal endothelial characteristics (endothelial cell density, endothelial cell variability, average of endothelial cell size and endothelial cell hexagonality) were introduced for quantitative analyses. Results: Eighteen studies (2077 were smokers and 6429 non-smokers) were identified, of which 17 studies provided data eligible for one or more of the quantitative analyses. When compared to non-smokers, smokers had a higher CCT (+3.3 μm, 95% CI: +0.9 to +5.7 μm, p = 0.007) and a lower endothelial cell density (−140 cells/mm2, 95% CI: −30 to −250 cells/mm2, p = 0.01). Other corneal endothelial measures did not differ significantly. Conclusion: Tobacco use is associated with a higher CCT and lower corneal endothelium cell density, but the clinical impact of these findings is small. Further studies are warranted on patients with a priori poor corneal health, where smoking may constitute an important risk of further progression, for example upon anterior segment surgery.
AB - Purpose: To investigate the impact of tobacco use on corneal thickness and corneal endothelial health. Methods: We searched the PubMed/MEDLINE, EMBASE, the Cochrane Central and all affiliated databases of the Web of Science on 20 July 2020. Two authors reviewed the studies and extracted the data in an independent fashion. Studies were reviewed qualitatively in the text, and central corneal thickness (CCT) and corneal endothelial characteristics (endothelial cell density, endothelial cell variability, average of endothelial cell size and endothelial cell hexagonality) were introduced for quantitative analyses. Results: Eighteen studies (2077 were smokers and 6429 non-smokers) were identified, of which 17 studies provided data eligible for one or more of the quantitative analyses. When compared to non-smokers, smokers had a higher CCT (+3.3 μm, 95% CI: +0.9 to +5.7 μm, p = 0.007) and a lower endothelial cell density (−140 cells/mm2, 95% CI: −30 to −250 cells/mm2, p = 0.01). Other corneal endothelial measures did not differ significantly. Conclusion: Tobacco use is associated with a higher CCT and lower corneal endothelium cell density, but the clinical impact of these findings is small. Further studies are warranted on patients with a priori poor corneal health, where smoking may constitute an important risk of further progression, for example upon anterior segment surgery.
U2 - 10.1111/aos.14897
DO - 10.1111/aos.14897
M3 - Review
C2 - 34021700
AN - SCOPUS:85106316090
VL - 100
SP - 26
EP - 34
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 1
ER -
ID: 312766965