Optical Coherence Tomography of Peripapillary Vessels in Giant Cell Arteritis and Ischaemic Ocular Disease
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Optical Coherence Tomography of Peripapillary Vessels in Giant Cell Arteritis and Ischaemic Ocular Disease. / Klefter, Oliver N.; Hansen, Michael S.; Willerslev, Anne; Faber, Carsten; Terslev, Lene; Jensen, Mads R.; Døhn, Uffe M.; Wiencke, Anne; Heegaard, Steffen; Hamann, Steffen.
I: Neuro-Ophthalmology, Bind 46, Nr. 6, 2022, s. 383-389.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Optical Coherence Tomography of Peripapillary Vessels in Giant Cell Arteritis and Ischaemic Ocular Disease
AU - Klefter, Oliver N.
AU - Hansen, Michael S.
AU - Willerslev, Anne
AU - Faber, Carsten
AU - Terslev, Lene
AU - Jensen, Mads R.
AU - Døhn, Uffe M.
AU - Wiencke, Anne
AU - Heegaard, Steffen
AU - Hamann, Steffen
N1 - Publisher Copyright: © 2022 Taylor & Francis Group, LLC.
PY - 2022
Y1 - 2022
N2 - With normal retinal blood flow, cross-sectional optical coherence tomography (OCT) of retinal vessels shows a structured intravascular reflectivity profile, resembling a ‘figure-of-8’. Altered profiles have been reported in vascular occlusive and haematological diseases. Giant cell arteritis (GCA) can cause visual loss, usually due to anterior ischaemic optic neuropathy (AION) or retinal artery occlusion. Our aim was to extend the assessment of OCT vascular profiles to patients with suspected GCA and to determine if any abnormalities were related to GCA per se or to ischaemic ocular conditions. This nested retrospective study included 61 eyes of 31 patients (13 with GCA). Six eyes had arteritic and seven eyes non-arteritic AION, three eyes had non-arteritic retinal artery occlusion, 11 eyes had other ocular conditions and 34 were unaffected control eyes. For each eye the appearance of structured intravascular profiles on peripapillary OCT was graded as present, partial, absent or uncertain. Non-presence of structured intravascular profiles was more frequent in AION and retinal artery occlusion than in other ocular conditions or unaffected eyes (Fisher’s test, p =.0047). Based on follow-up of 25 eyes, reflectivity profiles normalised in three out of four eyes after 85 (35–245) days. Vessel profiles were not associated with GCA (p =.32) and were similar in arteritic and non-arteritic AION (p =.66). In conclusion, absence of structured intravascular reflectivity profiles may be a marker of acute ischaemia in the anterior optic nerve or inner retina. However, it did not seem specific for GCA. The prognostic value warrants further studies.
AB - With normal retinal blood flow, cross-sectional optical coherence tomography (OCT) of retinal vessels shows a structured intravascular reflectivity profile, resembling a ‘figure-of-8’. Altered profiles have been reported in vascular occlusive and haematological diseases. Giant cell arteritis (GCA) can cause visual loss, usually due to anterior ischaemic optic neuropathy (AION) or retinal artery occlusion. Our aim was to extend the assessment of OCT vascular profiles to patients with suspected GCA and to determine if any abnormalities were related to GCA per se or to ischaemic ocular conditions. This nested retrospective study included 61 eyes of 31 patients (13 with GCA). Six eyes had arteritic and seven eyes non-arteritic AION, three eyes had non-arteritic retinal artery occlusion, 11 eyes had other ocular conditions and 34 were unaffected control eyes. For each eye the appearance of structured intravascular profiles on peripapillary OCT was graded as present, partial, absent or uncertain. Non-presence of structured intravascular profiles was more frequent in AION and retinal artery occlusion than in other ocular conditions or unaffected eyes (Fisher’s test, p =.0047). Based on follow-up of 25 eyes, reflectivity profiles normalised in three out of four eyes after 85 (35–245) days. Vessel profiles were not associated with GCA (p =.32) and were similar in arteritic and non-arteritic AION (p =.66). In conclusion, absence of structured intravascular reflectivity profiles may be a marker of acute ischaemia in the anterior optic nerve or inner retina. However, it did not seem specific for GCA. The prognostic value warrants further studies.
KW - anterior ischaemic optic neuropathy
KW - Giant cell arteritis
KW - optical coherence tomography
KW - retinal artery occlusion
KW - retinal blood flow
U2 - 10.1080/01658107.2022.2113901
DO - 10.1080/01658107.2022.2113901
M3 - Journal article
C2 - 36544584
AN - SCOPUS:85138157152
VL - 46
SP - 383
EP - 389
JO - Neuro-Ophthalmology
JF - Neuro-Ophthalmology
SN - 0165-8107
IS - 6
ER -
ID: 330475793