Young Adults With Anterior Ischemic Optic Neuropathy: A Multicenter Optic Disc Drusen Study
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Young Adults With Anterior Ischemic Optic Neuropathy : A Multicenter Optic Disc Drusen Study. / Hamann, Steffen; Malmqvist, Lasse; Wegener, Marianne; Fard, Masoud Aghsaei; Biousse, Valérie; Bursztyn, Lulu; Citirak, Gülsenay; Costello, Fiona; Crum, Alison V.; Digre, Kathleen; Fraser, J. Alexander; Huna-Baron, Ruth; Katz, Bradley; Lawlor, Mitchell; Newman, Nancy J.; Peragallo, Jason H.; Petzold, Axel; Sibony, Patrick A.; Subramanian, Prem S.; Warner, Judith E.A.; Wong, Sui H.; Fraser, Clare L.; Optic Disc Drusen Studies Consortium.
I: American Journal of Ophthalmology, Bind 217, 2020, s. 174-181.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Young Adults With Anterior Ischemic Optic Neuropathy
T2 - A Multicenter Optic Disc Drusen Study
AU - Hamann, Steffen
AU - Malmqvist, Lasse
AU - Wegener, Marianne
AU - Fard, Masoud Aghsaei
AU - Biousse, Valérie
AU - Bursztyn, Lulu
AU - Citirak, Gülsenay
AU - Costello, Fiona
AU - Crum, Alison V.
AU - Digre, Kathleen
AU - Fraser, J. Alexander
AU - Huna-Baron, Ruth
AU - Katz, Bradley
AU - Lawlor, Mitchell
AU - Newman, Nancy J.
AU - Peragallo, Jason H.
AU - Petzold, Axel
AU - Sibony, Patrick A.
AU - Subramanian, Prem S.
AU - Warner, Judith E.A.
AU - Wong, Sui H.
AU - Fraser, Clare L.
AU - Optic Disc Drusen Studies Consortium
PY - 2020
Y1 - 2020
N2 - Purpose: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION. Design: Retrospective, cross-sectional multicenter study. Methods: All patients with NA-AION 50 years old or younger, seen in neuro-ophthalmology clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, and March 31, 2019, were identified. Patients were included if ODD were diagnosed by any method, or if ODD were excluded by enhanced-depth imaging optical coherence tomography (EDI-OCT) using ODDS Consortium guidelines. NA-AION eyes with ODD were termed “ODD-AION”; those without were termed “NODD-AION”. Results: A total of 65 patients (127 eyes) with NA-AION were included (mean 41 years old). Of the 74 eyes with NA-AION, 51% had ODD-AION, whereas 43% of fellow eyes without NA-AION had ODD (P =.36). No significant differences were found between ODD-AION and NODD-AION eyes in terms of Snellen best-corrected VA or perimetric mean deviation. According to EDI-OCT results, 28% of eyes with NODD-AION had peripapillary hyperreflective ovoid mass-like structures (PHOMS); 7% had hyperreflective lines, whereas 54% with ODD-AION had PHOMS; and 66% had hyperreflective lines (P =.006 and P <.001, respectively). Conclusions: Most of these young NA-AION patients had ODD. This indicates that ODD may be an independent risk factor for the development of NA-AION, at least in younger patients. This study suggests ODD-AION be recognized as a novel diagnosis.
AB - Purpose: Optic disc drusen (ODD), present in 2% of the general population, have occasionally been reported in patients with nonarteritic anterior ischemic optic neuropathy (NA-AION). The purpose of this study was to examine the prevalence of ODD in young patients with NA-AION. Design: Retrospective, cross-sectional multicenter study. Methods: All patients with NA-AION 50 years old or younger, seen in neuro-ophthalmology clinics of the international ODDS (Optic Disc Drusen Studies) Consortium between April 1, 2017, and March 31, 2019, were identified. Patients were included if ODD were diagnosed by any method, or if ODD were excluded by enhanced-depth imaging optical coherence tomography (EDI-OCT) using ODDS Consortium guidelines. NA-AION eyes with ODD were termed “ODD-AION”; those without were termed “NODD-AION”. Results: A total of 65 patients (127 eyes) with NA-AION were included (mean 41 years old). Of the 74 eyes with NA-AION, 51% had ODD-AION, whereas 43% of fellow eyes without NA-AION had ODD (P =.36). No significant differences were found between ODD-AION and NODD-AION eyes in terms of Snellen best-corrected VA or perimetric mean deviation. According to EDI-OCT results, 28% of eyes with NODD-AION had peripapillary hyperreflective ovoid mass-like structures (PHOMS); 7% had hyperreflective lines, whereas 54% with ODD-AION had PHOMS; and 66% had hyperreflective lines (P =.006 and P <.001, respectively). Conclusions: Most of these young NA-AION patients had ODD. This indicates that ODD may be an independent risk factor for the development of NA-AION, at least in younger patients. This study suggests ODD-AION be recognized as a novel diagnosis.
U2 - 10.1016/j.ajo.2020.03.052
DO - 10.1016/j.ajo.2020.03.052
M3 - Journal article
C2 - 32298654
AN - SCOPUS:85086704385
VL - 217
SP - 174
EP - 181
JO - American Journal of Ophthalmology
JF - American Journal of Ophthalmology
SN - 0002-9394
ER -
ID: 260197548