The impact and prevalence of SARS-CoV-2 in patients with head and neck cancer and acute upper airway infection in a tertiary otorhinolaryngology referral center in Denmark
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The impact and prevalence of SARS-CoV-2 in patients with head and neck cancer and acute upper airway infection in a tertiary otorhinolaryngology referral center in Denmark. / Andersen, Peter Anders; Rasmussen, Kasper Møller Boje; Channir, Hani Ibrahim; von Buchwald, Christian; Cayé-Thomasen, Per; Klokker, Mads; Knudsen, Jenny Dahl; Kirkby, Nikolai Søren; Aanaes, Kasper; Jensen, Ramon Gordon.
I: European Archives of Oto-Rhino-Laryngology, Bind 278, Nr. 9, 09.2021, s. 3409-3415.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - The impact and prevalence of SARS-CoV-2 in patients with head and neck cancer and acute upper airway infection in a tertiary otorhinolaryngology referral center in Denmark
AU - Andersen, Peter Anders
AU - Rasmussen, Kasper Møller Boje
AU - Channir, Hani Ibrahim
AU - von Buchwald, Christian
AU - Cayé-Thomasen, Per
AU - Klokker, Mads
AU - Knudsen, Jenny Dahl
AU - Kirkby, Nikolai Søren
AU - Aanaes, Kasper
AU - Jensen, Ramon Gordon
N1 - Funding Information: No funds, grants, or other support was received. Publisher Copyright: © 2021, Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2021/9
Y1 - 2021/9
N2 - Purpose: To determine the prevalence of SARS-CoV-2 at a Danish tertiary referral otorhinolaryngology clinic during the first wave of the COVID-19 pandemic among patients with suspected acute upper airway infection (UAI) and patients operated for head and neck cancer (HNC), respectively. To monitor changes in the number of patient encounters for acute UAI and the number of referrals for the workup of HNC. Trial registration: NCT-04356560 (Clinicaltrials.gov). Methods: Prospective enrolled case series of all patients with suspected acute UAI (n = 88) and of patients undergoing surgery for HNC (n = 96), respectively, from March 23rd to May 5th, 2020, at a public tertiary referral otorhinolaryngology clinic in Denmark. SARS-CoV-2 was diagnosed with nasopharyngeal and oropharyngeal swabbing. Patients with suspected acute UAI had symptoms and definitive diagnoses registered in a database. Trends in the number of referrals and patient encounters were retrieved from an electronic patient journal system and analyzed retrospectively. Results: Eighty-eight patients with acute UAI were enrolled including 55 men and 34 women, median age of 31 years (range: 10 months to 82 years). One patient (1.1%) tested positive. Among 96 patients operated for HNC, zero tested positive. The number of referrals for HNC workup, and patient encounters for peritonsillar abscesses, decreased markedly in the first 3 weeks. Conclusion: The prevalence of SARS-CoV-2 during the first 6 weeks of the first wave was minimal among patients with acute UAI and zero among patients operated for HNC. The decrease in referrals for the workup of HNC may increase time to treatment initiation and patient morbidity.
AB - Purpose: To determine the prevalence of SARS-CoV-2 at a Danish tertiary referral otorhinolaryngology clinic during the first wave of the COVID-19 pandemic among patients with suspected acute upper airway infection (UAI) and patients operated for head and neck cancer (HNC), respectively. To monitor changes in the number of patient encounters for acute UAI and the number of referrals for the workup of HNC. Trial registration: NCT-04356560 (Clinicaltrials.gov). Methods: Prospective enrolled case series of all patients with suspected acute UAI (n = 88) and of patients undergoing surgery for HNC (n = 96), respectively, from March 23rd to May 5th, 2020, at a public tertiary referral otorhinolaryngology clinic in Denmark. SARS-CoV-2 was diagnosed with nasopharyngeal and oropharyngeal swabbing. Patients with suspected acute UAI had symptoms and definitive diagnoses registered in a database. Trends in the number of referrals and patient encounters were retrieved from an electronic patient journal system and analyzed retrospectively. Results: Eighty-eight patients with acute UAI were enrolled including 55 men and 34 women, median age of 31 years (range: 10 months to 82 years). One patient (1.1%) tested positive. Among 96 patients operated for HNC, zero tested positive. The number of referrals for HNC workup, and patient encounters for peritonsillar abscesses, decreased markedly in the first 3 weeks. Conclusion: The prevalence of SARS-CoV-2 during the first 6 weeks of the first wave was minimal among patients with acute UAI and zero among patients operated for HNC. The decrease in referrals for the workup of HNC may increase time to treatment initiation and patient morbidity.
KW - COVID-19
KW - Head and neck neoplasms
KW - Otolaryngology
KW - Respiratory tract infections
KW - Severe acute respiratory syndrome coronavirus 2
KW - Tertiary care centers
U2 - 10.1007/s00405-020-06514-6
DO - 10.1007/s00405-020-06514-6
M3 - Journal article
C2 - 33388982
AN - SCOPUS:85098710040
VL - 278
SP - 3409
EP - 3415
JO - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
JF - Archiv fur klinische und experimentelle Ohren- Nasen- und Kehlkopfheilkunde
SN - 0942-8992
IS - 9
ER -
ID: 284298434