Anti-dopamine D2 receptor antibodies in chronic tic disorders
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Aim: To investigate the association between circulating anti-dopamine D2 receptor (D2R) autoantibodies and the exacerbation of tics in children with chronic tic disorders (CTDs). Method: One hundred and thirty-seven children with CTDs (108 males, 29 females; mean age [SD] 10y 0mo [2y 7mo], range 4–16y) were recruited over 18 months. Patients were assessed at baseline, at tic exacerbation, and at 2 months after exacerbation. Serum anti-D2R antibodies were evaluated using a cell-based assay and blinded immunofluorescence microscopy scoring was performed by two raters. The association between visit type and presence of anti-D2R antibodies was measured with McNemar’s test and repeated-measure logistic regression models, adjusting for potential demographic and clinical confounders. Results: At exacerbation, 11 (8%) participants became anti-D2R-positive (‘early peri-exacerbation seroconverters’), and nine (6.6%) became anti-D2R-positive at post-exacerbation (‘late peri-exacerbation seroconverters’). The anti-D2R antibodies were significantly associated with exacerbations when compared to baseline (McNemar’s odds ratio=11, p=0.003) and conditional logistic regression confirmed this association (Z=3.49, p<0.001) after adjustment for demographic and clinical data and use of psychotropic drugs. Interpretation: There is a potential association between immune mechanisms and the severity course of tics in adolescents with CTDs.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Developmental Medicine and Child Neurology |
| Vol/bind | 62 |
| Udgave nummer | 10 |
| Sider (fra-til) | 1205-1212 |
| Antal sider | 8 |
| ISSN | 0012-1622 |
| DOI | |
| Status | Udgivet - 2020 |
Bibliografisk note
Funding Information:
We thank all members of the EMTICS collaborative group for their continued commitment to this project and in particular all colleagues at the various study centers who contributed to data collection and/or management: Zacharias Anastasiou, Alan Apter, Valentina Baglioni, Juliane Ball, Erika Bartolini, Noa Benaroya-Milshtein, Benjamin Bodmer, Emese Bognar, Bianka Burger, Judith Buse, Maura Buttiglione, Francesco Cardona, Marta Correa Vela, Roberta Creti, Andrea Dietrich, Nanette M. Debes, Androulla Efstratiou, Maria Cristina Ferro, Carolin Fremer, Blanca Garcia-Delgar, Maria Gariup, Marianthi Georgitsi, Mariangela Gulisano, Annelieke Hagen, Julie Hagstr?m, Tammy J. Hedderly, Isobel Heyman, Pieter J. Hoekstra, Chaim Huyser, Monica Imperi, Iordanis Karagiannidis, Giovanni Laviola, Simone Macri, Marcos Madruga-Garrido, Immaculada Margarit, Anna Marotta, Davide Martino, Ute C. Meier, Pablo Mir, Natalie Moll, Astrid Morer, Kirsten M?ller-Vahl, Alexander M?nchau, Peter Nagy, Valeria Neri, Tha?ra J.C. Openneer, Graziella Orefici, Peristera Paschou, Angela Peria?ez Vasco Alessandra Pellico, Onofrio Petruzzelli, Kerstin Plessen, Cesare Porcelli, Marina Redondo, Renata Rizzo, Paolo Roazzi, Veit Roessner, Daphna Ruhrman, Jaana M.L. Schnell, Anette Schrag, Gregor A. Sch?tze, Markus J. Schwarz, Paola Rosaria Silvestri, Liselotte Skov, Tamar Steinberg, Sara St?ber, Marco Tallon, Friederike Tagwerker Gloor, Susanne Walitza, Jennifer T?bing, Victoria Turner, Elif Weidinger, Zsanett Tarnok. The EMTICS project has received funding from the European Union?s Seventh Framework Programme for research, technological development, and demonstration under Grant agreement No. 278367. The authors and EMTICS collaborators are grateful to all patients, their siblings, and parents who made this research possible.
Funding Information:
The EMTICS project has received funding from the European Union’s Seventh Framework Programme for research, technological development, and demonstration under Grant agreement No. 278367. The authors and EMTICS collaborators are grateful to all patients, their siblings, and parents who made this research possible.
Publisher Copyright:
© 2020 Mac Keith Press
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