AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

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Standard

AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion. / Schuster, Anne; Klein, Eliane; Neirinckx, Virginie; Knudsen, Arnon Møldrup; Fabian, Carina; Hau, Ann-Christin; Dieterle, Monika; Oudin, Anais; Nazarov, Petr V; Golebiewska, Anna; Muller, Arnaud; Perez-Hernandez, Daniel; Rodius, Sophie; Dittmar, Gunnar; Bjerkvig, Rolf; Herold-Mende, Christel; Klink, Barbara; Kristensen, Bjarne Winther; Niclou, Simone P.

I: Nature Communications, Bind 11, Nr. 1, 11.12.2020, s. 6366.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schuster, A, Klein, E, Neirinckx, V, Knudsen, AM, Fabian, C, Hau, A-C, Dieterle, M, Oudin, A, Nazarov, PV, Golebiewska, A, Muller, A, Perez-Hernandez, D, Rodius, S, Dittmar, G, Bjerkvig, R, Herold-Mende, C, Klink, B, Kristensen, BW & Niclou, SP 2020, 'AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion', Nature Communications, bind 11, nr. 1, s. 6366. https://doi.org/10.1038/s41467-020-20029-y

APA

Schuster, A., Klein, E., Neirinckx, V., Knudsen, A. M., Fabian, C., Hau, A-C., Dieterle, M., Oudin, A., Nazarov, P. V., Golebiewska, A., Muller, A., Perez-Hernandez, D., Rodius, S., Dittmar, G., Bjerkvig, R., Herold-Mende, C., Klink, B., Kristensen, B. W., & Niclou, S. P. (2020). AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion. Nature Communications, 11(1), 6366. https://doi.org/10.1038/s41467-020-20029-y

Vancouver

Schuster A, Klein E, Neirinckx V, Knudsen AM, Fabian C, Hau A-C o.a. AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion. Nature Communications. 2020 dec. 11;11(1):6366. https://doi.org/10.1038/s41467-020-20029-y

Author

Schuster, Anne ; Klein, Eliane ; Neirinckx, Virginie ; Knudsen, Arnon Møldrup ; Fabian, Carina ; Hau, Ann-Christin ; Dieterle, Monika ; Oudin, Anais ; Nazarov, Petr V ; Golebiewska, Anna ; Muller, Arnaud ; Perez-Hernandez, Daniel ; Rodius, Sophie ; Dittmar, Gunnar ; Bjerkvig, Rolf ; Herold-Mende, Christel ; Klink, Barbara ; Kristensen, Bjarne Winther ; Niclou, Simone P. / AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion. I: Nature Communications. 2020 ; Bind 11, Nr. 1. s. 6366.

Bibtex

@article{fc534a7fd68a4a1f84e3d88bddf788db,
title = "AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion",
abstract = "The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity of GBM, whereas ZFAND3 overexpression increases motility in cells that were initially not invasive. At the mechanistic level, we find that ZFAND3 activity requires nuclear localization and integral zinc-finger domains. Our findings indicate that ZFAND3 acts within a nuclear protein complex to activate gene transcription and regulates the promoter of invasion-related genes such as COL6A2, FN1, and NRCAM. Further investigation in ZFAND3 function in GBM and other invasive cancers is warranted.",
author = "Anne Schuster and Eliane Klein and Virginie Neirinckx and Knudsen, {Arnon M{\o}ldrup} and Carina Fabian and Ann-Christin Hau and Monika Dieterle and Anais Oudin and Nazarov, {Petr V} and Anna Golebiewska and Arnaud Muller and Daniel Perez-Hernandez and Sophie Rodius and Gunnar Dittmar and Rolf Bjerkvig and Christel Herold-Mende and Barbara Klink and Kristensen, {Bjarne Winther} and Niclou, {Simone P}",
year = "2020",
month = dec,
day = "11",
doi = "10.1038/s41467-020-20029-y",
language = "English",
volume = "11",
pages = "6366",
journal = "Nature Communications",
issn = "2041-1722",
publisher = "Nature Research",
number = "1",

}

RIS

TY - JOUR

T1 - AN1-type zinc finger protein 3 (ZFAND3) is a transcriptional regulator that drives Glioblastoma invasion

AU - Schuster, Anne

AU - Klein, Eliane

AU - Neirinckx, Virginie

AU - Knudsen, Arnon Møldrup

AU - Fabian, Carina

AU - Hau, Ann-Christin

AU - Dieterle, Monika

AU - Oudin, Anais

AU - Nazarov, Petr V

AU - Golebiewska, Anna

AU - Muller, Arnaud

AU - Perez-Hernandez, Daniel

AU - Rodius, Sophie

AU - Dittmar, Gunnar

AU - Bjerkvig, Rolf

AU - Herold-Mende, Christel

AU - Klink, Barbara

AU - Kristensen, Bjarne Winther

AU - Niclou, Simone P

PY - 2020/12/11

Y1 - 2020/12/11

N2 - The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity of GBM, whereas ZFAND3 overexpression increases motility in cells that were initially not invasive. At the mechanistic level, we find that ZFAND3 activity requires nuclear localization and integral zinc-finger domains. Our findings indicate that ZFAND3 acts within a nuclear protein complex to activate gene transcription and regulates the promoter of invasion-related genes such as COL6A2, FN1, and NRCAM. Further investigation in ZFAND3 function in GBM and other invasive cancers is warranted.

AB - The infiltrative nature of Glioblastoma (GBM), the most aggressive primary brain tumor, critically prevents complete surgical resection and masks tumor cells behind the blood brain barrier reducing the efficacy of systemic treatment. Here, we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity of GBM, whereas ZFAND3 overexpression increases motility in cells that were initially not invasive. At the mechanistic level, we find that ZFAND3 activity requires nuclear localization and integral zinc-finger domains. Our findings indicate that ZFAND3 acts within a nuclear protein complex to activate gene transcription and regulates the promoter of invasion-related genes such as COL6A2, FN1, and NRCAM. Further investigation in ZFAND3 function in GBM and other invasive cancers is warranted.

U2 - 10.1038/s41467-020-20029-y

DO - 10.1038/s41467-020-20029-y

M3 - Journal article

C2 - 33311477

VL - 11

SP - 6366

JO - Nature Communications

JF - Nature Communications

SN - 2041-1722

IS - 1

ER -

ID: 364506457