Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. / Schonberg, David L; Miller, Tyler E; Wu, Qiulian; Flavahan, William A; Das, Nupur K; Hale, James S; Hubert, Christopher G; Mack, Stephen C; Jarrar, Awad M; Karl, Robert T; Rosager, Ann Mari; Nixon, Anne M; Tesar, Paul J; Hamerlik, Petra; Kristensen, Bjarne W; Horbinski, Craig; Connor, James R; Fox, Paul L; Lathia, Justin D; Rich, Jeremy N.

I: Cancer Cell, Bind 28, Nr. 4, 12.10.2015, s. 441-455.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Schonberg, DL, Miller, TE, Wu, Q, Flavahan, WA, Das, NK, Hale, JS, Hubert, CG, Mack, SC, Jarrar, AM, Karl, RT, Rosager, AM, Nixon, AM, Tesar, PJ, Hamerlik, P, Kristensen, BW, Horbinski, C, Connor, JR, Fox, PL, Lathia, JD & Rich, JN 2015, 'Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells', Cancer Cell, bind 28, nr. 4, s. 441-455. https://doi.org/10.1016/j.ccell.2015.09.002

APA

Schonberg, D. L., Miller, T. E., Wu, Q., Flavahan, W. A., Das, N. K., Hale, J. S., Hubert, C. G., Mack, S. C., Jarrar, A. M., Karl, R. T., Rosager, A. M., Nixon, A. M., Tesar, P. J., Hamerlik, P., Kristensen, B. W., Horbinski, C., Connor, J. R., Fox, P. L., Lathia, J. D., & Rich, J. N. (2015). Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. Cancer Cell, 28(4), 441-455. https://doi.org/10.1016/j.ccell.2015.09.002

Vancouver

Schonberg DL, Miller TE, Wu Q, Flavahan WA, Das NK, Hale JS o.a. Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. Cancer Cell. 2015 okt. 12;28(4):441-455. https://doi.org/10.1016/j.ccell.2015.09.002

Author

Schonberg, David L ; Miller, Tyler E ; Wu, Qiulian ; Flavahan, William A ; Das, Nupur K ; Hale, James S ; Hubert, Christopher G ; Mack, Stephen C ; Jarrar, Awad M ; Karl, Robert T ; Rosager, Ann Mari ; Nixon, Anne M ; Tesar, Paul J ; Hamerlik, Petra ; Kristensen, Bjarne W ; Horbinski, Craig ; Connor, James R ; Fox, Paul L ; Lathia, Justin D ; Rich, Jeremy N. / Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells. I: Cancer Cell. 2015 ; Bind 28, Nr. 4. s. 441-455.

Bibtex

@article{6689a926dc5943fba279de39a30474b9,

title = "Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells",

abstract = "Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors. Direct interrogation of iron uptake demonstrated that CSCs potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin, two core iron regulators, to propagate and form tumors in vivo. Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory axis, revealing an iron-regulated CSC pathway. Iron is a unique, primordial metal fundamental for earliest life forms, on which CSCs have an epigenetically programmed, targetable dependence.",

author = "Schonberg, {David L} and Miller, {Tyler E} and Qiulian Wu and Flavahan, {William A} and Das, {Nupur K} and Hale, {James S} and Hubert, {Christopher G} and Mack, {Stephen C} and Jarrar, {Awad M} and Karl, {Robert T} and Rosager, {Ann Mari} and Nixon, {Anne M} and Tesar, {Paul J} and Petra Hamerlik and Kristensen, {Bjarne W} and Craig Horbinski and Connor, {James R} and Fox, {Paul L} and Lathia, {Justin D} and Rich, {Jeremy N}",

year = "2015",

month = oct,

day = "12",

doi = "10.1016/j.ccell.2015.09.002",

language = "English",

volume = "28",

pages = "441--455",

journal = "Cancer Cell",

issn = "1535-6108",

publisher = "Cell Press",

number = "4",

}

RIS

TY - JOUR

T1 - Preferential Iron Trafficking Characterizes Glioblastoma Stem-like Cells

AU - Schonberg, David L

AU - Miller, Tyler E

AU - Wu, Qiulian

AU - Flavahan, William A

AU - Das, Nupur K

AU - Hale, James S

AU - Hubert, Christopher G

AU - Mack, Stephen C

AU - Jarrar, Awad M

AU - Karl, Robert T

AU - Rosager, Ann Mari

AU - Nixon, Anne M

AU - Tesar, Paul J

AU - Hamerlik, Petra

AU - Kristensen, Bjarne W

AU - Horbinski, Craig

AU - Connor, James R

AU - Fox, Paul L

AU - Lathia, Justin D

AU - Rich, Jeremy N

PY - 2015/10/12

Y1 - 2015/10/12

N2 - Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors. Direct interrogation of iron uptake demonstrated that CSCs potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin, two core iron regulators, to propagate and form tumors in vivo. Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory axis, revealing an iron-regulated CSC pathway. Iron is a unique, primordial metal fundamental for earliest life forms, on which CSCs have an epigenetically programmed, targetable dependence.

AB - Glioblastomas display hierarchies with self-renewing cancer stem-like cells (CSCs). RNA sequencing and enhancer mapping revealed regulatory programs unique to CSCs causing upregulation of the iron transporter transferrin, the top differentially expressed gene compared with tissue-specific progenitors. Direct interrogation of iron uptake demonstrated that CSCs potently extract iron from the microenvironment more effectively than other tumor cells. Systematic interrogation of iron flux determined that CSCs preferentially require transferrin receptor and ferritin, two core iron regulators, to propagate and form tumors in vivo. Depleting ferritin disrupted CSC mitotic progression, through the STAT3-FoxM1 regulatory axis, revealing an iron-regulated CSC pathway. Iron is a unique, primordial metal fundamental for earliest life forms, on which CSCs have an epigenetically programmed, targetable dependence.

U2 - 10.1016/j.ccell.2015.09.002

DO - 10.1016/j.ccell.2015.09.002

M3 - Journal article

C2 - 26461092

VL - 28

SP - 441

EP - 455

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 4

ER -

ID: 364507536

Institut for Klinisk Medicin