Small cell glioblastoma or small cell carcinoma: a case report and review of the literature
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Small cell glioblastoma or small cell carcinoma : a case report and review of the literature. / Hilbrandt, Christine; Sathyadas, Sathya; Dahlrot, Rikke H; Kristensen, Bjarne W.
I: Clinical Neuropathology, Bind 32, Nr. 4, 2013, s. 303-10.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Small cell glioblastoma or small cell carcinoma
T2 - a case report and review of the literature
AU - Hilbrandt, Christine
AU - Sathyadas, Sathya
AU - Dahlrot, Rikke H
AU - Kristensen, Bjarne W
PY - 2013
Y1 - 2013
N2 - It is often easy to distinguish between primary brain tumors and metastases based on morphology alone. However, in some cases immunohistochemistry (IHC) is necessary to obtain a diagnosis, but, as the present case report illustrates, this is not always straightforward. A 75-year old man was admitted to the hospital with left-sided loss of motor function. A MRI revealed a 6 cm tumor in the right temporoparietal area. The histology was consistent with both glioblastoma multiforme (GBM) and small cell lung carcinoma (SCLC) but IHC was suggestive of a SCLC metastasis. PET-CT revealed no enhancement in the lung, so the tumor was treated as a GBM. Eight months after the primary diagnosis a new MRI revealed metastases in the spinal cord, but there was still no enhancement in the lungs. We reviewed the literature concerning markers used to differentiate between GBM and SCLC and found that most of these markers showed limited specificity. It is further discussed whether the case illustrates an example of spontaneous regression of primary SCLC or might be an example of a GMB metastasizing to the spinal cord. Although immunohistochemical markers are of great help in many situations, the case illustrates important limitations and the need for better diagnostic markers.
AB - It is often easy to distinguish between primary brain tumors and metastases based on morphology alone. However, in some cases immunohistochemistry (IHC) is necessary to obtain a diagnosis, but, as the present case report illustrates, this is not always straightforward. A 75-year old man was admitted to the hospital with left-sided loss of motor function. A MRI revealed a 6 cm tumor in the right temporoparietal area. The histology was consistent with both glioblastoma multiforme (GBM) and small cell lung carcinoma (SCLC) but IHC was suggestive of a SCLC metastasis. PET-CT revealed no enhancement in the lung, so the tumor was treated as a GBM. Eight months after the primary diagnosis a new MRI revealed metastases in the spinal cord, but there was still no enhancement in the lungs. We reviewed the literature concerning markers used to differentiate between GBM and SCLC and found that most of these markers showed limited specificity. It is further discussed whether the case illustrates an example of spontaneous regression of primary SCLC or might be an example of a GMB metastasizing to the spinal cord. Although immunohistochemical markers are of great help in many situations, the case illustrates important limitations and the need for better diagnostic markers.
U2 - 10.5414/np300480
DO - 10.5414/np300480
M3 - Review
C2 - 23806221
VL - 32
SP - 303
EP - 310
JO - Clinical Neuropathology
JF - Clinical Neuropathology
SN - 0722-5091
IS - 4
ER -
ID: 364505866