Association between genes on chromosome 19p13.2 and panic disorder
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Association between genes on chromosome 19p13.2 and panic disorder. / Gregersen, Noomi O.; Buttenschon, Henriette N.; Hedemand, Anne; Nielsen, Marit N.; Dahl, Hans A.; Kristensen, Ann S.; Johansen, Oddbjorg; Woldbye, David P. D.; Erhardt, Angelika; Krusee, Torben A.; Wang, August G.; Borglum, Anders D.; Mors, Ole.
I: Psychiatric Genetics, Bind 26, Nr. 6, 12.2016, s. 287-292.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Association between genes on chromosome 19p13.2 and panic disorder
AU - Gregersen, Noomi O.
AU - Buttenschon, Henriette N.
AU - Hedemand, Anne
AU - Nielsen, Marit N.
AU - Dahl, Hans A.
AU - Kristensen, Ann S.
AU - Johansen, Oddbjorg
AU - Woldbye, David P. D.
AU - Erhardt, Angelika
AU - Krusee, Torben A.
AU - Wang, August G.
AU - Borglum, Anders D.
AU - Mors, Ole
PY - 2016/12
Y1 - 2016/12
N2 - Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes – small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) – these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.
AB - Panic disorder (PD) is a severe and disabling mental disorder, which is moderately heritable. In a previous study, we carried out a genome-wide association study using patients with PD and control individuals from the isolated population of the Faroe Islands and identified chromosome 19p13.2 as a candidate region. To further investigate this chromosomal region for association with PD, we analysed eight single nucleotide polymorphisms (SNPs) in three candidate genes – small-nuclear RNA activating complex, polypeptide 2 (SNAPC2), mitogen-activated protein kinase kinase 7 (MAP2K7) and leucine-rich repeat containing 8 family, member E (LRRC8E) – these genes have previously been directly or indirectly implicated in other mental disorders. A total of 511 patients with PD and 1029 healthy control individuals from the Faroe Islands, Denmark and Germany were included in the current study. SNPs covering the gene region of SNAPC2, MAP2K7 and LRRC8E were genotyped and tested for association with PD. In the Faroese cohort, rs7788 within SNAPC2 was significantly associated with PD, whereas rs3745383 within LRRC8E was nominally associated. No association was observed between the analysed SNPs and PD in the Danish cohorts. In the German women, we observed a nominal association between rs4804833 within MAP2K7 and PD. We present further evidence that chromosome 19p13.2 may harbour candidate genes that contribute towards the risk of developing PD. Moreover, the implication of the associated genes in other mental disorders may indicate shared genetic susceptibility between mental disorders. We show that associated variants may be sex specific, indicating the importance of carrying out a sex-specific association analysis of PD.
KW - LRRC8E
KW - MAP2K7
KW - 19p13.2
KW - panic disorder
KW - single nucleotide polymorphism
KW - SNAPC2
U2 - 10.1097/YPG.0000000000000147
DO - 10.1097/YPG.0000000000000147
M3 - Journal article
C2 - 27610895
VL - 26
SP - 287
EP - 292
JO - Psychiatric Genetics
JF - Psychiatric Genetics
SN - 0955-8829
IS - 6
ER -
ID: 169439965