Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones

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Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones. / Stanislaus, Sharleny; Faurholt-Jepsen, Maria; Vinberg, Maj; Coello, Klara; Kjærstad, Hanne Lie; Melbye, Sigurd; Sletved, Kimie S.O.; Christensen, Ellen Margrethe; Frost, Mads; Bardram, Jakob E.; Kessing, Lars Vedel.

I: Journal of Affective Disorders, Bind 271, 2020, s. 336-344.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Stanislaus, S, Faurholt-Jepsen, M, Vinberg, M, Coello, K, Kjærstad, HL, Melbye, S, Sletved, KSO, Christensen, EM, Frost, M, Bardram, JE & Kessing, LV 2020, 'Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones', Journal of Affective Disorders, bind 271, s. 336-344. https://doi.org/10.1016/j.jad.2020.03.049

APA

Stanislaus, S., Faurholt-Jepsen, M., Vinberg, M., Coello, K., Kjærstad, H. L., Melbye, S., Sletved, K. S. O., Christensen, E. M., Frost, M., Bardram, J. E., & Kessing, L. V. (2020). Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones. Journal of Affective Disorders, 271, 336-344. https://doi.org/10.1016/j.jad.2020.03.049

Vancouver

Stanislaus S, Faurholt-Jepsen M, Vinberg M, Coello K, Kjærstad HL, Melbye S o.a. Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones. Journal of Affective Disorders. 2020;271:336-344. https://doi.org/10.1016/j.jad.2020.03.049

Author

Stanislaus, Sharleny ; Faurholt-Jepsen, Maria ; Vinberg, Maj ; Coello, Klara ; Kjærstad, Hanne Lie ; Melbye, Sigurd ; Sletved, Kimie S.O. ; Christensen, Ellen Margrethe ; Frost, Mads ; Bardram, Jakob E. ; Kessing, Lars Vedel. / Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones. I: Journal of Affective Disorders. 2020 ; Bind 271. s. 336-344.

Bibtex

@article{6ee99bd415064446a9cc82a9f582c458,
title = "Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones",
abstract = "Objectives: To investigate whether mood instability (MI) qualify as a trait marker for bipolar disorder (BD) we investigated: 1) differences in smartphone-based self-reported MI between three groups: patients with newly diagnosed BD, unaffected first-degree relatives (UR), and healthy control individuals (HC); 2) the correlation between MI and functioning, stress, and duration of illness, respectively; and 3) the validity of smartphone-based self-evaluated mood ratings as compared to observer-based ratings of depressed and manic mood. Methods: 203 patients with newly diagnosed BD, 54 UR and 109 HC were included as part of the longitudinal Bipolar Illness Onset study. Participants completed daily smartphone-based mood ratings for a period of up to two years and were clinically assessed with ratings of depression, mania and functioning. Results: Mood instability scores were statistically significantly higher in patients with BD compared with HC (mean=1.18, 95%CI: 1.12;1.24 vs 1.05, 95%CI: 0.98;1.13, p = 0.007) and did not differ between patients with BD and UR (mean=1.17, 95%CI: 1.07;1.28, p = 0.91). For patients, increased MI scores correlated positively with impaired functioning (p<0.001), increased stress level (p<0.001) and increasing number of prior mood episodes (p<0.001). Smartphone-based mood ratings correlated with ratings of mood according to sub-item 1 on the Hamilton Depression Rating Scale 17-items and the Young Mania Rating Scale, respectively (p´s<0.001). Limitation: The study had a smaller number of UR than planned. Conclusion: Mood instability is increased in patients with newly diagnosed BD and unaffected relatives and associated with decreased functioning. The findings highlight MI as a potential trait marker for BD.",
keywords = "Bipolar disorder, Electronic monitoring, Mood instability, Self-reports, Smartphone",
author = "Sharleny Stanislaus and Maria Faurholt-Jepsen and Maj Vinberg and Klara Coello and Kj{\ae}rstad, {Hanne Lie} and Sigurd Melbye and Sletved, {Kimie S.O.} and Christensen, {Ellen Margrethe} and Mads Frost and Bardram, {Jakob E.} and Kessing, {Lars Vedel}",
year = "2020",
doi = "10.1016/j.jad.2020.03.049",
language = "English",
volume = "271",
pages = "336--344",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mood instability in patients with newly diagnosed bipolar disorder, unaffected relatives, and healthy control individuals measured daily using smartphones

AU - Stanislaus, Sharleny

AU - Faurholt-Jepsen, Maria

AU - Vinberg, Maj

AU - Coello, Klara

AU - Kjærstad, Hanne Lie

AU - Melbye, Sigurd

AU - Sletved, Kimie S.O.

AU - Christensen, Ellen Margrethe

AU - Frost, Mads

AU - Bardram, Jakob E.

AU - Kessing, Lars Vedel

PY - 2020

Y1 - 2020

N2 - Objectives: To investigate whether mood instability (MI) qualify as a trait marker for bipolar disorder (BD) we investigated: 1) differences in smartphone-based self-reported MI between three groups: patients with newly diagnosed BD, unaffected first-degree relatives (UR), and healthy control individuals (HC); 2) the correlation between MI and functioning, stress, and duration of illness, respectively; and 3) the validity of smartphone-based self-evaluated mood ratings as compared to observer-based ratings of depressed and manic mood. Methods: 203 patients with newly diagnosed BD, 54 UR and 109 HC were included as part of the longitudinal Bipolar Illness Onset study. Participants completed daily smartphone-based mood ratings for a period of up to two years and were clinically assessed with ratings of depression, mania and functioning. Results: Mood instability scores were statistically significantly higher in patients with BD compared with HC (mean=1.18, 95%CI: 1.12;1.24 vs 1.05, 95%CI: 0.98;1.13, p = 0.007) and did not differ between patients with BD and UR (mean=1.17, 95%CI: 1.07;1.28, p = 0.91). For patients, increased MI scores correlated positively with impaired functioning (p<0.001), increased stress level (p<0.001) and increasing number of prior mood episodes (p<0.001). Smartphone-based mood ratings correlated with ratings of mood according to sub-item 1 on the Hamilton Depression Rating Scale 17-items and the Young Mania Rating Scale, respectively (p´s<0.001). Limitation: The study had a smaller number of UR than planned. Conclusion: Mood instability is increased in patients with newly diagnosed BD and unaffected relatives and associated with decreased functioning. The findings highlight MI as a potential trait marker for BD.

AB - Objectives: To investigate whether mood instability (MI) qualify as a trait marker for bipolar disorder (BD) we investigated: 1) differences in smartphone-based self-reported MI between three groups: patients with newly diagnosed BD, unaffected first-degree relatives (UR), and healthy control individuals (HC); 2) the correlation between MI and functioning, stress, and duration of illness, respectively; and 3) the validity of smartphone-based self-evaluated mood ratings as compared to observer-based ratings of depressed and manic mood. Methods: 203 patients with newly diagnosed BD, 54 UR and 109 HC were included as part of the longitudinal Bipolar Illness Onset study. Participants completed daily smartphone-based mood ratings for a period of up to two years and were clinically assessed with ratings of depression, mania and functioning. Results: Mood instability scores were statistically significantly higher in patients with BD compared with HC (mean=1.18, 95%CI: 1.12;1.24 vs 1.05, 95%CI: 0.98;1.13, p = 0.007) and did not differ between patients with BD and UR (mean=1.17, 95%CI: 1.07;1.28, p = 0.91). For patients, increased MI scores correlated positively with impaired functioning (p<0.001), increased stress level (p<0.001) and increasing number of prior mood episodes (p<0.001). Smartphone-based mood ratings correlated with ratings of mood according to sub-item 1 on the Hamilton Depression Rating Scale 17-items and the Young Mania Rating Scale, respectively (p´s<0.001). Limitation: The study had a smaller number of UR than planned. Conclusion: Mood instability is increased in patients with newly diagnosed BD and unaffected relatives and associated with decreased functioning. The findings highlight MI as a potential trait marker for BD.

KW - Bipolar disorder

KW - Electronic monitoring

KW - Mood instability

KW - Self-reports

KW - Smartphone

UR - http://www.scopus.com/inward/record.url?scp=85084517356&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2020.03.049

DO - 10.1016/j.jad.2020.03.049

M3 - Journal article

C2 - 32479333

AN - SCOPUS:85084517356

VL - 271

SP - 336

EP - 344

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -

ID: 255448328