Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?

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Standard

Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success? / Ravndal, Maren; Idorn, Lars; Nielsen, Anne Kathrine Møller; Kelly, Benjamin; Nielsen, Kim Gjerum; Nielsen, Dorte Guldbrand; Hjortdal, Vibeke.

I: International Journal of Cardiology, Bind 387, 131137, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ravndal, M, Idorn, L, Nielsen, AKM, Kelly, B, Nielsen, KG, Nielsen, DG & Hjortdal, V 2023, 'Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?', International Journal of Cardiology, bind 387, 131137. https://doi.org/10.1016/j.ijcard.2023.131137

APA

Ravndal, M., Idorn, L., Nielsen, A. K. M., Kelly, B., Nielsen, K. G., Nielsen, D. G., & Hjortdal, V. (2023). Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success? International Journal of Cardiology, 387, [131137]. https://doi.org/10.1016/j.ijcard.2023.131137

Vancouver

Ravndal M, Idorn L, Nielsen AKM, Kelly B, Nielsen KG, Nielsen DG o.a. Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success? International Journal of Cardiology. 2023;387. 131137. https://doi.org/10.1016/j.ijcard.2023.131137

Author

Ravndal, Maren ; Idorn, Lars ; Nielsen, Anne Kathrine Møller ; Kelly, Benjamin ; Nielsen, Kim Gjerum ; Nielsen, Dorte Guldbrand ; Hjortdal, Vibeke. / Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?. I: International Journal of Cardiology. 2023 ; Bind 387.

Bibtex

@article{014da536a80e45b993cf03d64e9d608f,
title = "Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?",
abstract = "Background: Most Fontan patients have impaired exercise capacity, and a further decline in exercise capacity over time seems inevitable. However, few longitudinal studies exist, and there is a lack of data from newer eras. We aimed to describe the natural evolution of exercise capacity over a 10-year period in a contemporary, population-based cohort of Danish Fontan patients. Methods: The study was a nationwide, prospective study. A cardiopulmonary exercise test (CPET) was used to assess the exercise capacity. All Danish Fontan patients who participated in a national study in 2011 (CPET1), were invited to a follow-up visit in 2021 (CPET2). All patients who completed CPET1 and CPET2 with a respiratory exchange ratio over 1.0 were included. The main outcome was percent predicted VO2peak (%pred VO2peak). At the time of CPET2, patients filled out a questionnaire including questions regarding physical activity. Results: Seventy-seven patients completed both CPET1 and CPET2, and seventy patients completed the questionnaire. The time interval between the two CPETs was 10.4 ± 0.9 years. The median age was 15 years at CPET1 and 26 years at CPET2. The exercise capacity remained stable with a mean %pred VO2peak of 53.8 ± 11.3 at CPET1 and 55.6 ± 10.9 in CPET2 (p = 0.314). Higher levels of vigorous physical activity were associated with higher %pred VO2peak in CPET2 in a multivariate regression model. Conclusion: The %pred VO2peak remained stable over a ten-year period in this population-based Fontan cohort. Higher levels of self-reported vigorous physical activity were associated with higher %pred VO2peak in the most recent CPET.",
keywords = "Cardiopulmonary exercise test, Congenital heart disease, Fontan circulation, Physical activity",
author = "Maren Ravndal and Lars Idorn and Nielsen, {Anne Kathrine M{\o}ller} and Benjamin Kelly and Nielsen, {Kim Gjerum} and Nielsen, {Dorte Guldbrand} and Vibeke Hjortdal",
note = "Funding Information: This work was supported by a common grant from The Novo Nordisk Foundation ( #NFF17SA0030576 ). Publisher Copyright: {\textcopyright} 2023 The Author(s)",
year = "2023",
doi = "10.1016/j.ijcard.2023.131137",
language = "English",
volume = "387",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Exercise capacity in the Danish Fontan population remains stable after ten years of follow-up - is physical activity the key to success?

AU - Ravndal, Maren

AU - Idorn, Lars

AU - Nielsen, Anne Kathrine Møller

AU - Kelly, Benjamin

AU - Nielsen, Kim Gjerum

AU - Nielsen, Dorte Guldbrand

AU - Hjortdal, Vibeke

N1 - Funding Information: This work was supported by a common grant from The Novo Nordisk Foundation ( #NFF17SA0030576 ). Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Background: Most Fontan patients have impaired exercise capacity, and a further decline in exercise capacity over time seems inevitable. However, few longitudinal studies exist, and there is a lack of data from newer eras. We aimed to describe the natural evolution of exercise capacity over a 10-year period in a contemporary, population-based cohort of Danish Fontan patients. Methods: The study was a nationwide, prospective study. A cardiopulmonary exercise test (CPET) was used to assess the exercise capacity. All Danish Fontan patients who participated in a national study in 2011 (CPET1), were invited to a follow-up visit in 2021 (CPET2). All patients who completed CPET1 and CPET2 with a respiratory exchange ratio over 1.0 were included. The main outcome was percent predicted VO2peak (%pred VO2peak). At the time of CPET2, patients filled out a questionnaire including questions regarding physical activity. Results: Seventy-seven patients completed both CPET1 and CPET2, and seventy patients completed the questionnaire. The time interval between the two CPETs was 10.4 ± 0.9 years. The median age was 15 years at CPET1 and 26 years at CPET2. The exercise capacity remained stable with a mean %pred VO2peak of 53.8 ± 11.3 at CPET1 and 55.6 ± 10.9 in CPET2 (p = 0.314). Higher levels of vigorous physical activity were associated with higher %pred VO2peak in CPET2 in a multivariate regression model. Conclusion: The %pred VO2peak remained stable over a ten-year period in this population-based Fontan cohort. Higher levels of self-reported vigorous physical activity were associated with higher %pred VO2peak in the most recent CPET.

AB - Background: Most Fontan patients have impaired exercise capacity, and a further decline in exercise capacity over time seems inevitable. However, few longitudinal studies exist, and there is a lack of data from newer eras. We aimed to describe the natural evolution of exercise capacity over a 10-year period in a contemporary, population-based cohort of Danish Fontan patients. Methods: The study was a nationwide, prospective study. A cardiopulmonary exercise test (CPET) was used to assess the exercise capacity. All Danish Fontan patients who participated in a national study in 2011 (CPET1), were invited to a follow-up visit in 2021 (CPET2). All patients who completed CPET1 and CPET2 with a respiratory exchange ratio over 1.0 were included. The main outcome was percent predicted VO2peak (%pred VO2peak). At the time of CPET2, patients filled out a questionnaire including questions regarding physical activity. Results: Seventy-seven patients completed both CPET1 and CPET2, and seventy patients completed the questionnaire. The time interval between the two CPETs was 10.4 ± 0.9 years. The median age was 15 years at CPET1 and 26 years at CPET2. The exercise capacity remained stable with a mean %pred VO2peak of 53.8 ± 11.3 at CPET1 and 55.6 ± 10.9 in CPET2 (p = 0.314). Higher levels of vigorous physical activity were associated with higher %pred VO2peak in CPET2 in a multivariate regression model. Conclusion: The %pred VO2peak remained stable over a ten-year period in this population-based Fontan cohort. Higher levels of self-reported vigorous physical activity were associated with higher %pred VO2peak in the most recent CPET.

KW - Cardiopulmonary exercise test

KW - Congenital heart disease

KW - Fontan circulation

KW - Physical activity

U2 - 10.1016/j.ijcard.2023.131137

DO - 10.1016/j.ijcard.2023.131137

M3 - Journal article

C2 - 37355241

AN - SCOPUS:85163539575

VL - 387

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

M1 - 131137

ER -

ID: 388831156