Fuel metabolism in a pig myocutaneous island flap model
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Fuel metabolism in a pig myocutaneous island flap model. / Hjortdal, V E; Kjølseth, D; Henriksen, T B; Hansen, E S; Møller, N.
I: Plastic and Reconstructive Surgery, Bind 88, Nr. 4, 10.1991, s. 664-72.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Fuel metabolism in a pig myocutaneous island flap model
AU - Hjortdal, V E
AU - Kjølseth, D
AU - Henriksen, T B
AU - Hansen, E S
AU - Møller, N
PY - 1991/10
Y1 - 1991/10
N2 - Unilateral denervated myocutaneous island flaps based on the superior epigastric vessels were raised in 24 pigs and the metabolic changes during the first 6 postoperative hours were monitored. Secondary to flap elevation, decreased arteriovenous (A-V) differences in oxygen, glucose, and alanine levels were observed, indicating the opening of A-V shunts and increased arterialization of the venous blood. Venous outflow increased during the first 3 hours, but the A-V differences in all metabolites were constant over the entire 6-hour observation period. Exchange of intermediary metabolites therefore increased within the first 3 hours, after which a steady state was established. The main flap fuels seemed to be fatty acids, muscle proteins, and glycogen, whereas blood-borne carbohydrates and ketone bodies played only a minor role as energy sources. Anaerobic metabolism was increased secondary to flap elevation from 2 to 6 percent as compared with preelevation values. No changes were found in concentrations of plasma catecholamines, which were constantly high. An average weight gain of 3 to 4 percent per hour was equally distributed to skin, subcutis, panniculus carnosus, and muscle. Thus the flap seemed to adapt to the new perfusion pattern within a few hours by a slightly increased anaerobic metabolism, but still with an oxidative metabolism of more than 90 percent.
AB - Unilateral denervated myocutaneous island flaps based on the superior epigastric vessels were raised in 24 pigs and the metabolic changes during the first 6 postoperative hours were monitored. Secondary to flap elevation, decreased arteriovenous (A-V) differences in oxygen, glucose, and alanine levels were observed, indicating the opening of A-V shunts and increased arterialization of the venous blood. Venous outflow increased during the first 3 hours, but the A-V differences in all metabolites were constant over the entire 6-hour observation period. Exchange of intermediary metabolites therefore increased within the first 3 hours, after which a steady state was established. The main flap fuels seemed to be fatty acids, muscle proteins, and glycogen, whereas blood-borne carbohydrates and ketone bodies played only a minor role as energy sources. Anaerobic metabolism was increased secondary to flap elevation from 2 to 6 percent as compared with preelevation values. No changes were found in concentrations of plasma catecholamines, which were constantly high. An average weight gain of 3 to 4 percent per hour was equally distributed to skin, subcutis, panniculus carnosus, and muscle. Thus the flap seemed to adapt to the new perfusion pattern within a few hours by a slightly increased anaerobic metabolism, but still with an oxidative metabolism of more than 90 percent.
KW - 3-Hydroxybutyric Acid
KW - Alanine/blood
KW - Animals
KW - Blood Glucose/analysis
KW - Body Temperature
KW - Epinephrine/blood
KW - Glucagon/blood
KW - Glucose/metabolism
KW - Glycerol/blood
KW - Hydroxybutyrates/blood
KW - Insulin/blood
KW - Lactates/blood
KW - Muscles/blood supply
KW - Norepinephrine/blood
KW - Oxygen/blood
KW - Regional Blood Flow
KW - Skin/blood supply
KW - Surgical Flaps
KW - Swine
U2 - 10.1097/00006534-199110000-00017
DO - 10.1097/00006534-199110000-00017
M3 - Journal article
C2 - 1896538
VL - 88
SP - 664
EP - 672
JO - Plastic and Reconstructive Surgery
JF - Plastic and Reconstructive Surgery
SN - 0032-1052
IS - 4
ER -
ID: 244280720