N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates: A Cohort Study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates : A Cohort Study. / Sellmer, Anna; Hjortdal, Vibeke Elisabeth; Bjerre, Jesper Vandborg; Schmidt, Michael Rahbek; McNamara, Patrick J; Bech, Bodil Hammer; Henriksen, Tine Brink.

I: PLoS ONE, Bind 10, Nr. 10, 2015, s. e0140079.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Sellmer, A, Hjortdal, VE, Bjerre, JV, Schmidt, MR, McNamara, PJ, Bech, BH & Henriksen, TB 2015, 'N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates: A Cohort Study', PLoS ONE, bind 10, nr. 10, s. e0140079. https://doi.org/10.1371/journal.pone.0140079

APA

Sellmer, A., Hjortdal, V. E., Bjerre, J. V., Schmidt, M. R., McNamara, P. J., Bech, B. H., & Henriksen, T. B. (2015). N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates: A Cohort Study. PLoS ONE, 10(10), e0140079. https://doi.org/10.1371/journal.pone.0140079

Vancouver

Sellmer A, Hjortdal VE, Bjerre JV, Schmidt MR, McNamara PJ, Bech BH o.a. N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates: A Cohort Study. PLoS ONE. 2015;10(10):e0140079. https://doi.org/10.1371/journal.pone.0140079

Author

Sellmer, Anna ; Hjortdal, Vibeke Elisabeth ; Bjerre, Jesper Vandborg ; Schmidt, Michael Rahbek ; McNamara, Patrick J ; Bech, Bodil Hammer ; Henriksen, Tine Brink. / N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates : A Cohort Study. I: PLoS ONE. 2015 ; Bind 10, Nr. 10. s. e0140079.

Bibtex

@article{eddd34a1e9344371921075ce55f095fa,
title = "N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates: A Cohort Study",
abstract = "BACKGROUND: Bronchopulmonary dysplasia (BPD) is a serious complication of preterm birth. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) has been suggested as a marker that may predict BPD within a few days after birth.OBJECTIVES: To investigate the association between NT-proBNP day three and bronchopulmonary dysplasia (BPD) or death and further to assess the impact of patent ductus arteriosus (PDA) on this association in neonates born before 32 gestational weeks.METHODS: A cohort study of 183 neonates born before 32 gestational weeks consecutively admitted to the Neonatal Intensive Care Unit, Aarhus University Hospital, Denmark. On day three plasma samples were collected and echocardiography carried out. NT-proBNP was measured by routine immunoassays. The combined outcome BPD or death was assessed at 36 weeks of postmenstrual age. Receiver operator characteristic (ROC) analysis was performed to determine the discrimination ability of NT-proBNP by the natural log continuous measure to recognize BPD or death. The association of BPD or death was assessed in relation to natural log NT-proBNP levels day three.RESULTS: The risk of BPD or death increased 1.7-fold with one unit increase of natural log NT-proBNP day three when adjusted for gestational age at birth (OR = 1.7, 95% CI 1.3; 2.3). The association was found both in neonates with and without a PDA. Adjusting for GA, PDA diameter, LA:Ao-ratio, or early onset sepsis did not change the estimate.CONCLUSION: We found NT-proBNP to be associated with BPD or death in very preterm neonates. This association was not only explained by the PDA. We speculate that NT-proBNP may help the identification of neonates at risk of BPD as early as postnatal day three.",
keywords = "Biomarkers/blood, Bronchopulmonary Dysplasia/blood, Cohort Studies, Denmark, Ductus Arteriosus, Patent/diagnostic imaging, Female, Humans, Infant, Infant, Extremely Premature/blood, Infant, Newborn, Male, Natriuretic Peptide, Brain/blood, Peptide Fragments/blood, Premature Birth/blood, Risk Factors, Ultrasonography",
author = "Anna Sellmer and Hjortdal, {Vibeke Elisabeth} and Bjerre, {Jesper Vandborg} and Schmidt, {Michael Rahbek} and McNamara, {Patrick J} and Bech, {Bodil Hammer} and Henriksen, {Tine Brink}",
year = "2015",
doi = "10.1371/journal.pone.0140079",
language = "English",
volume = "10",
pages = "e0140079",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - N-Terminal Pro-B Type Natriuretic Peptide as a Marker of Bronchopulmonary Dysplasia or Death in Very Preterm Neonates

T2 - A Cohort Study

AU - Sellmer, Anna

AU - Hjortdal, Vibeke Elisabeth

AU - Bjerre, Jesper Vandborg

AU - Schmidt, Michael Rahbek

AU - McNamara, Patrick J

AU - Bech, Bodil Hammer

AU - Henriksen, Tine Brink

PY - 2015

Y1 - 2015

N2 - BACKGROUND: Bronchopulmonary dysplasia (BPD) is a serious complication of preterm birth. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) has been suggested as a marker that may predict BPD within a few days after birth.OBJECTIVES: To investigate the association between NT-proBNP day three and bronchopulmonary dysplasia (BPD) or death and further to assess the impact of patent ductus arteriosus (PDA) on this association in neonates born before 32 gestational weeks.METHODS: A cohort study of 183 neonates born before 32 gestational weeks consecutively admitted to the Neonatal Intensive Care Unit, Aarhus University Hospital, Denmark. On day three plasma samples were collected and echocardiography carried out. NT-proBNP was measured by routine immunoassays. The combined outcome BPD or death was assessed at 36 weeks of postmenstrual age. Receiver operator characteristic (ROC) analysis was performed to determine the discrimination ability of NT-proBNP by the natural log continuous measure to recognize BPD or death. The association of BPD or death was assessed in relation to natural log NT-proBNP levels day three.RESULTS: The risk of BPD or death increased 1.7-fold with one unit increase of natural log NT-proBNP day three when adjusted for gestational age at birth (OR = 1.7, 95% CI 1.3; 2.3). The association was found both in neonates with and without a PDA. Adjusting for GA, PDA diameter, LA:Ao-ratio, or early onset sepsis did not change the estimate.CONCLUSION: We found NT-proBNP to be associated with BPD or death in very preterm neonates. This association was not only explained by the PDA. We speculate that NT-proBNP may help the identification of neonates at risk of BPD as early as postnatal day three.

AB - BACKGROUND: Bronchopulmonary dysplasia (BPD) is a serious complication of preterm birth. Plasma N-terminal pro-B type natriuretic peptide (NT-proBNP) has been suggested as a marker that may predict BPD within a few days after birth.OBJECTIVES: To investigate the association between NT-proBNP day three and bronchopulmonary dysplasia (BPD) or death and further to assess the impact of patent ductus arteriosus (PDA) on this association in neonates born before 32 gestational weeks.METHODS: A cohort study of 183 neonates born before 32 gestational weeks consecutively admitted to the Neonatal Intensive Care Unit, Aarhus University Hospital, Denmark. On day three plasma samples were collected and echocardiography carried out. NT-proBNP was measured by routine immunoassays. The combined outcome BPD or death was assessed at 36 weeks of postmenstrual age. Receiver operator characteristic (ROC) analysis was performed to determine the discrimination ability of NT-proBNP by the natural log continuous measure to recognize BPD or death. The association of BPD or death was assessed in relation to natural log NT-proBNP levels day three.RESULTS: The risk of BPD or death increased 1.7-fold with one unit increase of natural log NT-proBNP day three when adjusted for gestational age at birth (OR = 1.7, 95% CI 1.3; 2.3). The association was found both in neonates with and without a PDA. Adjusting for GA, PDA diameter, LA:Ao-ratio, or early onset sepsis did not change the estimate.CONCLUSION: We found NT-proBNP to be associated with BPD or death in very preterm neonates. This association was not only explained by the PDA. We speculate that NT-proBNP may help the identification of neonates at risk of BPD as early as postnatal day three.

KW - Biomarkers/blood

KW - Bronchopulmonary Dysplasia/blood

KW - Cohort Studies

KW - Denmark

KW - Ductus Arteriosus, Patent/diagnostic imaging

KW - Female

KW - Humans

KW - Infant

KW - Infant, Extremely Premature/blood

KW - Infant, Newborn

KW - Male

KW - Natriuretic Peptide, Brain/blood

KW - Peptide Fragments/blood

KW - Premature Birth/blood

KW - Risk Factors

KW - Ultrasonography

U2 - 10.1371/journal.pone.0140079

DO - 10.1371/journal.pone.0140079

M3 - Journal article

C2 - 26452045

VL - 10

SP - e0140079

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

ER -

ID: 242413333