Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs

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Standard

Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs. / Glavind-Kristensen, M; Brix-Christensen, V; Toennesen, E; Ravn, H B; Forman, A; Sorensen, K; Hjortdal, V E.

I: Acta Anaesthesiologica Scandinavica, Bind 46, Nr. 7, 08.2002, s. 853-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Glavind-Kristensen, M, Brix-Christensen, V, Toennesen, E, Ravn, HB, Forman, A, Sorensen, K & Hjortdal, VE 2002, 'Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs', Acta Anaesthesiologica Scandinavica, bind 46, nr. 7, s. 853-9. https://doi.org/10.1034/j.1399-6576.2002.460716.x

APA

Glavind-Kristensen, M., Brix-Christensen, V., Toennesen, E., Ravn, H. B., Forman, A., Sorensen, K., & Hjortdal, V. E. (2002). Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiologica Scandinavica, 46(7), 853-9. https://doi.org/10.1034/j.1399-6576.2002.460716.x

Vancouver

Glavind-Kristensen M, Brix-Christensen V, Toennesen E, Ravn HB, Forman A, Sorensen K o.a. Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs. Acta Anaesthesiologica Scandinavica. 2002 aug.;46(7):853-9. https://doi.org/10.1034/j.1399-6576.2002.460716.x

Author

Glavind-Kristensen, M ; Brix-Christensen, V ; Toennesen, E ; Ravn, H B ; Forman, A ; Sorensen, K ; Hjortdal, V E. / Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs. I: Acta Anaesthesiologica Scandinavica. 2002 ; Bind 46, Nr. 7. s. 853-9.

Bibtex

@article{f267010228ac4b0e819651fe9e865224,
title = "Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs",
abstract = "BACKGROUND: In neonatal pigs cardiopulmonary bypass (CPB) is associated with endothelial dysfunction in isolated large pulmonary arteries. It is, however, of great importance if this functional change extends to the small pulmonary resistance arteries, which are the key regulators of pulmonary flow and pressure. The aim of this study was to assess changes in pulmonary microvascular function after CPB using a clinically relevant pediatric procedure.METHODS: From three groups of neonatal pigs (CPB-, sham- and control group) pulmonary resistance arteries and systemic resistance arteries (from skeletal muscle) were isolated and mounted as ring preparations in wire myographs. Vessel diameters were less than 500 microm. Concentration-response curves were constructed for norepinephrine (NA), vasopressin (Vp), and the thromboxane A2-analog U46619, while the endothelium-dependent and -independent vasodilator functions were assessed as responses to acetylcholine and nitric oxide (NO).RESULTS: Maximum pulmonary vasodilator response to acetylcholine was attenuated after CPB compared with sham-operated and control animals (P=0.04). NO-induced relaxation, and contractile responses to NA, Vp, and U46619 were not influenced by CPB. In systemic arteries no changes in contractile or relaxant responses were seen after CPB.CONCLUSION: CPB seems to induce pulmonary endothelial dysfunction in pulmonary but not peripheral resistance arteries in neonatal piglets.",
keywords = "15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology, Acetylcholine/pharmacology, Animals, Animals, Newborn, Cardiopulmonary Bypass/adverse effects, Dose-Response Relationship, Drug, Endothelium, Vascular/physiopathology, Female, In Vitro Techniques, Microcirculation/drug effects, Muscle, Skeletal/physiopathology, Nitric Oxide/pharmacology, Norepinephrine/pharmacology, Pulmonary Artery/physiopathology, Swine, Vascular Resistance/drug effects, Vasoconstriction/drug effects, Vasoconstrictor Agents/pharmacology, Vasodilation/drug effects, Vasodilator Agents/pharmacology, Vasopressins/pharmacology",
author = "M Glavind-Kristensen and V Brix-Christensen and E Toennesen and Ravn, {H B} and A Forman and K Sorensen and Hjortdal, {V E}",
year = "2002",
month = aug,
doi = "10.1034/j.1399-6576.2002.460716.x",
language = "English",
volume = "46",
pages = "853--9",
journal = "Acta Anaesthesiologica Scandinavica",
issn = "0001-5172",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Pulmonary endothelial dysfunction after cardiopulmonary bypass in neonatal pigs

AU - Glavind-Kristensen, M

AU - Brix-Christensen, V

AU - Toennesen, E

AU - Ravn, H B

AU - Forman, A

AU - Sorensen, K

AU - Hjortdal, V E

PY - 2002/8

Y1 - 2002/8

N2 - BACKGROUND: In neonatal pigs cardiopulmonary bypass (CPB) is associated with endothelial dysfunction in isolated large pulmonary arteries. It is, however, of great importance if this functional change extends to the small pulmonary resistance arteries, which are the key regulators of pulmonary flow and pressure. The aim of this study was to assess changes in pulmonary microvascular function after CPB using a clinically relevant pediatric procedure.METHODS: From three groups of neonatal pigs (CPB-, sham- and control group) pulmonary resistance arteries and systemic resistance arteries (from skeletal muscle) were isolated and mounted as ring preparations in wire myographs. Vessel diameters were less than 500 microm. Concentration-response curves were constructed for norepinephrine (NA), vasopressin (Vp), and the thromboxane A2-analog U46619, while the endothelium-dependent and -independent vasodilator functions were assessed as responses to acetylcholine and nitric oxide (NO).RESULTS: Maximum pulmonary vasodilator response to acetylcholine was attenuated after CPB compared with sham-operated and control animals (P=0.04). NO-induced relaxation, and contractile responses to NA, Vp, and U46619 were not influenced by CPB. In systemic arteries no changes in contractile or relaxant responses were seen after CPB.CONCLUSION: CPB seems to induce pulmonary endothelial dysfunction in pulmonary but not peripheral resistance arteries in neonatal piglets.

AB - BACKGROUND: In neonatal pigs cardiopulmonary bypass (CPB) is associated with endothelial dysfunction in isolated large pulmonary arteries. It is, however, of great importance if this functional change extends to the small pulmonary resistance arteries, which are the key regulators of pulmonary flow and pressure. The aim of this study was to assess changes in pulmonary microvascular function after CPB using a clinically relevant pediatric procedure.METHODS: From three groups of neonatal pigs (CPB-, sham- and control group) pulmonary resistance arteries and systemic resistance arteries (from skeletal muscle) were isolated and mounted as ring preparations in wire myographs. Vessel diameters were less than 500 microm. Concentration-response curves were constructed for norepinephrine (NA), vasopressin (Vp), and the thromboxane A2-analog U46619, while the endothelium-dependent and -independent vasodilator functions were assessed as responses to acetylcholine and nitric oxide (NO).RESULTS: Maximum pulmonary vasodilator response to acetylcholine was attenuated after CPB compared with sham-operated and control animals (P=0.04). NO-induced relaxation, and contractile responses to NA, Vp, and U46619 were not influenced by CPB. In systemic arteries no changes in contractile or relaxant responses were seen after CPB.CONCLUSION: CPB seems to induce pulmonary endothelial dysfunction in pulmonary but not peripheral resistance arteries in neonatal piglets.

KW - 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid/pharmacology

KW - Acetylcholine/pharmacology

KW - Animals

KW - Animals, Newborn

KW - Cardiopulmonary Bypass/adverse effects

KW - Dose-Response Relationship, Drug

KW - Endothelium, Vascular/physiopathology

KW - Female

KW - In Vitro Techniques

KW - Microcirculation/drug effects

KW - Muscle, Skeletal/physiopathology

KW - Nitric Oxide/pharmacology

KW - Norepinephrine/pharmacology

KW - Pulmonary Artery/physiopathology

KW - Swine

KW - Vascular Resistance/drug effects

KW - Vasoconstriction/drug effects

KW - Vasoconstrictor Agents/pharmacology

KW - Vasodilation/drug effects

KW - Vasodilator Agents/pharmacology

KW - Vasopressins/pharmacology

U2 - 10.1034/j.1399-6576.2002.460716.x

DO - 10.1034/j.1399-6576.2002.460716.x

M3 - Journal article

C2 - 12139542

VL - 46

SP - 853

EP - 859

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 7

ER -

ID: 243519794