Mild Cognitive Impairment Is Associated with Poorer Nutritional Status on Hospital Admission and after Discharge in Acutely Hospitalized Older Patients

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In acutely hospitalized older patients (≥65 years), the association between mild cognitive impairment (MCI) and malnutrition is poorly described. We hypothesized that (1) MCI is associated with nutritional status on admission and after discharge; (2) MCI is associated with a change in nutritional status; and (3) a potential association is partly explained by frailty, comorbidity, medication use, and age. We combined data from a randomized controlled trial (control group data) and a prospective cohort study ( NCT01964482 and NCT03052192). Nutritional status was assessed on admission and follow-up using the Mini Nutritional Assessment—Short Form. MCI or intact cognition (noMCI) was classified by three cognitive performance tests at follow-up. Data on frailty, comorbidity, medication use, and age were drawn from patient journals. MCI (n = 42) compared to noMCI (n = 47) was associated with poorer nutritional status with an average difference of −1.29 points (CI: −2.30; −0.28) on admission and −1.64 points (CI: −2.57; −0.70) at 4-week follow-up. Only age influenced the estimates of −0.85 (CI: −1.86; 0.17) and −1.29 (CI: −2.25; −0.34), respectively. In acutely hospitalized older patients, there is an association between MCI and poorer nutritional status upon admission and four weeks after discharge. The association is partly explained by higher age.

TidsskriftGeriatrics (Switzerland)
Udgave nummer5
Antal sider16
StatusUdgivet - 2022

Bibliografisk note

Funding Information:
This research was funded by the Department of Clinical Research, Copenhagen University Hospital, Hvidovre, Denmark. Further, FAM-CPH was funded by Doctor Sofus Carl Emil Friis’ and his wife’s (Olga Doris Friis’) scholarship (01/2018), Copenhagen University Hospital, Denmark (12/2017 and 09/2018); the Capital Region Pharmacy; the Toyota Foundation (grant number KJ/BG-9305 F); and the Capital Region of Denmark (04/2016). STAND-Cph was funded by the Danish Ministry of Health (grant number 9170); Danish Regions/The Danish Health Confederation (OK11); the Lundbeck Foundation; (UCSF) (grant numbers FP 07/2012, FP 48/2012 and FP 61/2013); the Research Foundation of Hvidovre Hospital (06/2012); the Capital Region of Copenhagen (04/2013); and the Danish Foundation for Research in Physiotherapy (grant numbers 11/2012, 09/2013, 01/2013, 07/2013 and 12/2013).

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© 2022 by the authors.

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