Perioperative prevention of persistent pain after total hip and knee arthroplasty-Protocol for two systematic reviews
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Perioperative prevention of persistent pain after total hip and knee arthroplasty-Protocol for two systematic reviews. / Laigaard, Jens; Karlsen, Anders; Maagaard, Mathias; Rosenberg, Lukas Kristian; Creutzburg, Andreas; Lunn, Troels Haxholdt; Mathiesen, Ole; Overgaard, Soren.
I: Acta Anaesthesiologica Scandinavica, Bind 66, Nr. 6, 2022, s. 772-777.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Perioperative prevention of persistent pain after total hip and knee arthroplasty-Protocol for two systematic reviews
AU - Laigaard, Jens
AU - Karlsen, Anders
AU - Maagaard, Mathias
AU - Rosenberg, Lukas Kristian
AU - Creutzburg, Andreas
AU - Lunn, Troels Haxholdt
AU - Mathiesen, Ole
AU - Overgaard, Soren
PY - 2022
Y1 - 2022
N2 - Background Between 9% and 20% of patients experience moderate to severe persistent postoperative pain after total hip or knee arthroplasty. Severe immediate postoperative pain limits rehabilitation and is associated with the development of persistent postoperative pain. Therefore, perioperative analgesic and physiotherapeutic interventions are of interest to reduce persistent pain. In two systematic reviews with identical methodology, we aim to investigate the effects of (a) perioperative analgesic interventions and (b) physiotherapeutic interventions in reducing persistent pain after total hip and knee arthroplasty. Methods We will include randomised and cluster-randomised controlled trials on perioperative analgesic and physiotherapeutic interventions for patients undergoing elective total hip or knee arthroplasty for osteoarthritis. After contact with the authors, trials without pain data 3-24 months postoperatively will be excluded. Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and reference lists will be searched for eligible trials. Two authors will independently screen, extract data and assess the risk of bias. The primary outcome is pain scores 3-24 months postoperatively. Meta-analyses will be performed for interventions with two or more trials. We will conduct trial sequential analyses and assign Grading of Recommendations, Assessment, Development and Evaluation (GRADE) ratings. Conclusion No previous review on reduction of persistent postoperative pain has included non-pharmacological or invasive analgesic techniques. These two reviews with identical methodology will summarise the evidence of analgesic and physiotherapeutic perioperative interventions to prevent persistent pain. PROSPERO registration CRD42021284175.
AB - Background Between 9% and 20% of patients experience moderate to severe persistent postoperative pain after total hip or knee arthroplasty. Severe immediate postoperative pain limits rehabilitation and is associated with the development of persistent postoperative pain. Therefore, perioperative analgesic and physiotherapeutic interventions are of interest to reduce persistent pain. In two systematic reviews with identical methodology, we aim to investigate the effects of (a) perioperative analgesic interventions and (b) physiotherapeutic interventions in reducing persistent pain after total hip and knee arthroplasty. Methods We will include randomised and cluster-randomised controlled trials on perioperative analgesic and physiotherapeutic interventions for patients undergoing elective total hip or knee arthroplasty for osteoarthritis. After contact with the authors, trials without pain data 3-24 months postoperatively will be excluded. Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase and reference lists will be searched for eligible trials. Two authors will independently screen, extract data and assess the risk of bias. The primary outcome is pain scores 3-24 months postoperatively. Meta-analyses will be performed for interventions with two or more trials. We will conduct trial sequential analyses and assign Grading of Recommendations, Assessment, Development and Evaluation (GRADE) ratings. Conclusion No previous review on reduction of persistent postoperative pain has included non-pharmacological or invasive analgesic techniques. These two reviews with identical methodology will summarise the evidence of analgesic and physiotherapeutic perioperative interventions to prevent persistent pain. PROSPERO registration CRD42021284175.
KW - chronic opioid therapy
KW - chronic pain
KW - clinical diversity in meta-analyses
KW - persistent postoperative pain
KW - persistent postsurgical pain
KW - protocol
KW - systematic review
KW - trial sequential analysis
KW - UTILIZATION RATES
KW - MANAGEMENT
KW - INTENSITY
KW - IMPACT
U2 - 10.1111/aas.14061
DO - 10.1111/aas.14061
M3 - Journal article
C2 - 35325472
VL - 66
SP - 772
EP - 777
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 6
ER -
ID: 308113950