Socio-economic status, functioning and cognition in young versus adult patients newly diagnosed with bipolar disorder and their unaffected relatives: results from a cross-sectional study
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Socio-economic status, functioning and cognition in young versus adult patients newly diagnosed with bipolar disorder and their unaffected relatives : results from a cross-sectional study. / Coello, Klara; Stanislaus, Christoffer; Stanislaus, Sharleny; Sletved, Kimie Stefanie Ormstrup; Kjærstad, Hanne Lie; Miskowiak, Kamilla Woznika; Faurholt-Jepsen, Maria; Pagsberg, Anne Katrine; Vinberg, Maj; Kessing, Lars Vedel.
I: Journal of Affective Disorders, Bind 351, 2024, s. 458-471.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Socio-economic status, functioning and cognition in young versus adult patients newly diagnosed with bipolar disorder and their unaffected relatives
T2 - results from a cross-sectional study
AU - Coello, Klara
AU - Stanislaus, Christoffer
AU - Stanislaus, Sharleny
AU - Sletved, Kimie Stefanie Ormstrup
AU - Kjærstad, Hanne Lie
AU - Miskowiak, Kamilla Woznika
AU - Faurholt-Jepsen, Maria
AU - Pagsberg, Anne Katrine
AU - Vinberg, Maj
AU - Kessing, Lars Vedel
N1 - Publisher Copyright: © 2024 Elsevier B.V.
PY - 2024
Y1 - 2024
N2 - Background: Bipolar disorders (BD) figures on top of the World Health Organization classification of disabling disorders. It is unclear if there are socioeconomic, functioning, and cognition differences in young patients newly diagnosed with BD and whether these are different for young and adult patients newly diagnosed with BD. Understanding these differences is important for tailored treatment and support. Methods: Participant groups included 401 patients newly diagnosed with BD, 145 of their unaffected first-degree relatives (UR) and 209 healthy control individuals (HC). First, we compared socio-economic status, functioning and cognition between young patients newly diagnosed with BD (150), UR (61) and HC (92) (15–25 years) and adult patients newly diagnosed with BD (251), UR (84) and HC (117) (>25 years), respectively. Second, within patients, we compared functioning and cognition between young and adult patients newly diagnosed with BD. Results: In both participant groups, patients newly diagnosed with BD, and to a lesser degree UR, had lower socio-economic status and impaired functioning and cognition compared with HC. Further, young patients newly diagnosed with BD were less functionally impaired, than adults newly diagnosed with BD, whereas cognition did not differ between groups. Limitations: Applied tools for assessments of functioning and cognition are not validated below age 18. Conclusions: Overall, lower socio-economic status and impaired functioning and cognition were found both in young and adult patients newly diagnosed with BD and their UR compared with young and adult HC, respectively. Young patients were less functionally impaired than adults, but cognition was similarly impaired.
AB - Background: Bipolar disorders (BD) figures on top of the World Health Organization classification of disabling disorders. It is unclear if there are socioeconomic, functioning, and cognition differences in young patients newly diagnosed with BD and whether these are different for young and adult patients newly diagnosed with BD. Understanding these differences is important for tailored treatment and support. Methods: Participant groups included 401 patients newly diagnosed with BD, 145 of their unaffected first-degree relatives (UR) and 209 healthy control individuals (HC). First, we compared socio-economic status, functioning and cognition between young patients newly diagnosed with BD (150), UR (61) and HC (92) (15–25 years) and adult patients newly diagnosed with BD (251), UR (84) and HC (117) (>25 years), respectively. Second, within patients, we compared functioning and cognition between young and adult patients newly diagnosed with BD. Results: In both participant groups, patients newly diagnosed with BD, and to a lesser degree UR, had lower socio-economic status and impaired functioning and cognition compared with HC. Further, young patients newly diagnosed with BD were less functionally impaired, than adults newly diagnosed with BD, whereas cognition did not differ between groups. Limitations: Applied tools for assessments of functioning and cognition are not validated below age 18. Conclusions: Overall, lower socio-economic status and impaired functioning and cognition were found both in young and adult patients newly diagnosed with BD and their UR compared with young and adult HC, respectively. Young patients were less functionally impaired than adults, but cognition was similarly impaired.
KW - Bipolar disorder
KW - Cognition
KW - Functioning
KW - Newly diagnosed
KW - Socio-economic status
KW - Unaffected relatives
U2 - 10.1016/j.jad.2024.01.174
DO - 10.1016/j.jad.2024.01.174
M3 - Journal article
C2 - 38266931
AN - SCOPUS:85184067549
VL - 351
SP - 458
EP - 471
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 383709345