TY - JOUR

T1 - Generic outcome set for the international registry on Laser trEAtments in Dermatology (LEAD)

T2 - a protocol for a Delphi study to achieve consensus on what to measure

AU - Fransen, Frederike

AU - Spuls, Phyllis

AU - Alam, Murad

AU - Badawi, Ashraf

AU - Boixeda, Pablo

AU - Haedersdal, Merete

AU - Hamzavi, Iltefat

AU - Hedelund, Lene

AU - Kelly, Kristen M

AU - Kono, Tara

AU - Laubach, Hans Joachim

AU - Manuskiatti, Woraphong

AU - Marini, Leonardo

AU - Nouri, Keyvan

AU - Paasch, Uwe

AU - Passeron, Thierry

AU - Prinsen, Cecilia A C Sanna

AU - Verner, Ines

AU - Wolkerstorfer, Albert

N1 - © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.

PY - 2020

Y1 - 2020

N2 - INTRODUCTION: While laser technology has expanded the armamentarium of treatment for various skin diseases during the past years, heterogeneity in study outcomes hampers comparability and appropriate evidence synthesis. Part of these issues can be addressed by developing a generic outcome set. Using the Delphi method, this study aims to seek consensus between key stakeholders on relevant generic outcomes (what to measure) for implementation in the international registry on Laser trEAtments in Dermatology (LEAD). The registry is focused on collecting research data on various laser treatments for skin disorders.METHODS AND ANALYSIS: By reviewing the literature and involvement of key stakeholder groups and adult patients in need or after laser surgery and health professionals, a preliminary list of outcomes will be generated and categorised into domains. Using these outcomes, an international three-round Delphi study will be performed to rate the importance of outcomes in the selection of a generic outcome set. Participants are allowed to provide new outcomes to the preliminary list for revisions during the first Delphi round. Finally, results will be discussed during a consensus meeting to agree on generic outcomes to be used in the LEAD registry.ETHICS AND DISSEMINATION: An ethics approval was not applicable (W19_290 # 18.336). The study is registered with the Cochrane Skin Core OUtcome Set INitiative) and the Core Outcome Measures in Effectiveness Trials initiative. Procedures will be conducted according to the Declaration of Helsinki. The findings will be disseminated through peer-reviewed publications and conference presentations.

AB - INTRODUCTION: While laser technology has expanded the armamentarium of treatment for various skin diseases during the past years, heterogeneity in study outcomes hampers comparability and appropriate evidence synthesis. Part of these issues can be addressed by developing a generic outcome set. Using the Delphi method, this study aims to seek consensus between key stakeholders on relevant generic outcomes (what to measure) for implementation in the international registry on Laser trEAtments in Dermatology (LEAD). The registry is focused on collecting research data on various laser treatments for skin disorders.METHODS AND ANALYSIS: By reviewing the literature and involvement of key stakeholder groups and adult patients in need or after laser surgery and health professionals, a preliminary list of outcomes will be generated and categorised into domains. Using these outcomes, an international three-round Delphi study will be performed to rate the importance of outcomes in the selection of a generic outcome set. Participants are allowed to provide new outcomes to the preliminary list for revisions during the first Delphi round. Finally, results will be discussed during a consensus meeting to agree on generic outcomes to be used in the LEAD registry.ETHICS AND DISSEMINATION: An ethics approval was not applicable (W19_290 # 18.336). The study is registered with the Cochrane Skin Core OUtcome Set INitiative) and the Core Outcome Measures in Effectiveness Trials initiative. Procedures will be conducted according to the Declaration of Helsinki. The findings will be disseminated through peer-reviewed publications and conference presentations.

KW - Consensus

KW - Delphi Technique

KW - Dermatology/methods

KW - Humans

KW - Laser Therapy/methods

KW - Outcome Assessment, Health Care

KW - Registries

KW - Research Design

KW - Stakeholder Participation

U2 - 10.1136/bmjopen-2020-038145

DO - 10.1136/bmjopen-2020-038145

M3 - Journal article

C2 - 32595165

VL - 10

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 6

M1 - e038145

ER -