Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients

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Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients. / Togsverd-Bo, Katrine; Philipsen, Peter Alshede; Hædersdal, Merete; Wulf, Hans Christian Olsen.

I: Journal of Photochemistry and Photobiology, B: Biology, Bind 178, 2018, s. 577-583.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Togsverd-Bo, K, Philipsen, PA, Hædersdal, M & Wulf, HCO 2018, 'Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients', Journal of Photochemistry and Photobiology, B: Biology, bind 178, s. 577-583. https://doi.org/10.1016/j.jphotobiol.2017.12.001

APA

Togsverd-Bo, K., Philipsen, P. A., Hædersdal, M., & Wulf, H. C. O. (2018). Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients. Journal of Photochemistry and Photobiology, B: Biology, 178, 577-583. https://doi.org/10.1016/j.jphotobiol.2017.12.001

Vancouver

Togsverd-Bo K, Philipsen PA, Hædersdal M, Wulf HCO. Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients. Journal of Photochemistry and Photobiology, B: Biology. 2018;178:577-583. https://doi.org/10.1016/j.jphotobiol.2017.12.001

Author

Togsverd-Bo, Katrine ; Philipsen, Peter Alshede ; Hædersdal, Merete ; Wulf, Hans Christian Olsen. / Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients. I: Journal of Photochemistry and Photobiology, B: Biology. 2018 ; Bind 178. s. 577-583.

Bibtex

@article{186bdaddf84447b4be68c29a90b14bdd,
title = "Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients",
abstract = "IMPORTANCE: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.OBJECTIVES: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines.MATERIALS AND METHODS: Danish OTRs with (n=15) and without a history of skin cancer (n=15) kept sun diaries from May to September and wore personal dosimeters recording time-stamped UVR doses in standard erythema doses (SED). Photodamage was quantified as skin autofluorescence with excitation at 370nm (F370) and 430nm (F430), skin pigmentation (pigment protection factor, PPF), and black light-evaluated solar lentigines.RESULTS: OTRs with skin cancer received a higher UVR dose than OTRs without skin cancer (median 116 SED vs. 67 SED, p=0.07) and UVR exposure doses were correlated with increased PPF (p=0.052) and F370 on the shoulder (F370shoulder) (p=0.04). We found that skin cancer was associated with F370shoulder (OR 10.53, CI 3.3-31,938; p=0.018) and time since transplantation (OR 1.34, CI 0.95-1.91, p=0.097). A cut-off at 7.2 arbitrary units, 89% of OTRs with skin cancer had F370shoulder values above 7.2 arbitrary units and F370shoulder was additionally related to patient age (p=0.09) and black light-evaluated solar lentigines (p=0.04).CONCLUSION: F370 autofluorescence indicates objectively measured photodamage and may be used for individual risk assessment of skin cancer development in OTRs.",
keywords = "Adult, Aged, Female, Humans, Lentigo/etiology, Luminescent Measurements, Male, Middle Aged, Odds Ratio, Organ Transplantation, Seasons, Skin/chemistry, Skin Neoplasms/etiology, Skin Pigmentation/radiation effects, Transplant Recipients, Ultraviolet Rays",
author = "Katrine Togsverd-Bo and Philipsen, {Peter Alshede} and Merete H{\ae}dersdal and Wulf, {Hans Christian Olsen}",
year = "2018",
doi = "10.1016/j.jphotobiol.2017.12.001",
language = "English",
volume = "178",
pages = "577--583",
journal = "Journal of Photochemistry and Photobiology B: Biology",
issn = "1011-1344",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Skin autofluorescence reflects individual seasonal UV exposure, skin photodamage and skin cancer development in organ transplant recipients

AU - Togsverd-Bo, Katrine

AU - Philipsen, Peter Alshede

AU - Hædersdal, Merete

AU - Wulf, Hans Christian Olsen

PY - 2018

Y1 - 2018

N2 - IMPORTANCE: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.OBJECTIVES: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines.MATERIALS AND METHODS: Danish OTRs with (n=15) and without a history of skin cancer (n=15) kept sun diaries from May to September and wore personal dosimeters recording time-stamped UVR doses in standard erythema doses (SED). Photodamage was quantified as skin autofluorescence with excitation at 370nm (F370) and 430nm (F430), skin pigmentation (pigment protection factor, PPF), and black light-evaluated solar lentigines.RESULTS: OTRs with skin cancer received a higher UVR dose than OTRs without skin cancer (median 116 SED vs. 67 SED, p=0.07) and UVR exposure doses were correlated with increased PPF (p=0.052) and F370 on the shoulder (F370shoulder) (p=0.04). We found that skin cancer was associated with F370shoulder (OR 10.53, CI 3.3-31,938; p=0.018) and time since transplantation (OR 1.34, CI 0.95-1.91, p=0.097). A cut-off at 7.2 arbitrary units, 89% of OTRs with skin cancer had F370shoulder values above 7.2 arbitrary units and F370shoulder was additionally related to patient age (p=0.09) and black light-evaluated solar lentigines (p=0.04).CONCLUSION: F370 autofluorescence indicates objectively measured photodamage and may be used for individual risk assessment of skin cancer development in OTRs.

AB - IMPORTANCE: Ultraviolet radiation (UVR)-induced skin cancers varies among organ transplant recipients (OTRs). To improve individual risk assessment of skin cancer, objectively quantified skin photodamage is needed.OBJECTIVES: We measured personal UVR-exposure dose in OTRs and assessed the relation between individual UVR exposure, skin cancer and objectively measured photodamage in terms of skin autofluorescence, pigmentation, and black light-evaluated solar lentigines.MATERIALS AND METHODS: Danish OTRs with (n=15) and without a history of skin cancer (n=15) kept sun diaries from May to September and wore personal dosimeters recording time-stamped UVR doses in standard erythema doses (SED). Photodamage was quantified as skin autofluorescence with excitation at 370nm (F370) and 430nm (F430), skin pigmentation (pigment protection factor, PPF), and black light-evaluated solar lentigines.RESULTS: OTRs with skin cancer received a higher UVR dose than OTRs without skin cancer (median 116 SED vs. 67 SED, p=0.07) and UVR exposure doses were correlated with increased PPF (p=0.052) and F370 on the shoulder (F370shoulder) (p=0.04). We found that skin cancer was associated with F370shoulder (OR 10.53, CI 3.3-31,938; p=0.018) and time since transplantation (OR 1.34, CI 0.95-1.91, p=0.097). A cut-off at 7.2 arbitrary units, 89% of OTRs with skin cancer had F370shoulder values above 7.2 arbitrary units and F370shoulder was additionally related to patient age (p=0.09) and black light-evaluated solar lentigines (p=0.04).CONCLUSION: F370 autofluorescence indicates objectively measured photodamage and may be used for individual risk assessment of skin cancer development in OTRs.

KW - Adult

KW - Aged

KW - Female

KW - Humans

KW - Lentigo/etiology

KW - Luminescent Measurements

KW - Male

KW - Middle Aged

KW - Odds Ratio

KW - Organ Transplantation

KW - Seasons

KW - Skin/chemistry

KW - Skin Neoplasms/etiology

KW - Skin Pigmentation/radiation effects

KW - Transplant Recipients

KW - Ultraviolet Rays

U2 - 10.1016/j.jphotobiol.2017.12.001

DO - 10.1016/j.jphotobiol.2017.12.001

M3 - Journal article

C2 - 29272850

VL - 178

SP - 577

EP - 583

JO - Journal of Photochemistry and Photobiology B: Biology

JF - Journal of Photochemistry and Photobiology B: Biology

SN - 1011-1344

ER -

ID: 217511607