Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study

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Adult height is associated with increased risk of ovarian cancer : a Mendelian randomisation study. / Australian Ovarian Cancer Study Group.

I: British Journal of Cancer, Bind 118, Nr. 8, 2018, s. 1123-1129.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Australian Ovarian Cancer Study Group 2018, 'Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study', British Journal of Cancer, bind 118, nr. 8, s. 1123-1129. https://doi.org/10.1038/s41416-018-0011-3

APA

Australian Ovarian Cancer Study Group (2018). Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. British Journal of Cancer, 118(8), 1123-1129. https://doi.org/10.1038/s41416-018-0011-3

Vancouver

Australian Ovarian Cancer Study Group. Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study. British Journal of Cancer. 2018;118(8):1123-1129. https://doi.org/10.1038/s41416-018-0011-3

Author

Australian Ovarian Cancer Study Group. / Adult height is associated with increased risk of ovarian cancer : a Mendelian randomisation study. I: British Journal of Cancer. 2018 ; Bind 118, Nr. 8. s. 1123-1129.

Bibtex

@article{c9ec1fab9f194433b8a70b558ea1251f,
title = "Adult height is associated with increased risk of ovarian cancer: a Mendelian randomisation study",
abstract = "BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Body Height/genetics, Carcinoma, Ovarian Epithelial/epidemiology, Case-Control Studies, Female, Genetic Predisposition to Disease, Geography, Humans, Mendelian Randomization Analysis, Middle Aged, Ovarian Neoplasms/epidemiology, Risk Factors, Young Adult",
author = "Dixon-Suen, {Suzanne C} and Nagle, {Christina M} and Thrift, {Aaron P} and Pharoah, {Paul D P} and Ailith Ewing and Pearce, {Celeste Leigh} and Wei Zheng and Georgia Chenevix-Trench and Fasching, {Peter A} and Beckmann, {Matthias W} and Diether Lambrechts and Ignace Vergote and Sandrina Lambrechts and {Van Nieuwenhuysen}, Els and Rossing, {Mary Anne} and Doherty, {Jennifer A} and Wicklund, {Kristine G} and Jenny Chang-Claude and Jung, {Audrey Y} and Moysich, {Kirsten B} and Kunle Odunsi and Goodman, {Marc T} and Wilkens, {Lynne R} and Thompson, {Pamela J} and Shvetsov, {Yurii B} and Thilo D{\"o}rk and Tjoung-Won Park-Simon and Peter Hillemanns and Natalia Bogdanova and Ralf Butzow and Heli Nevanlinna and Pelttari, {Liisa M} and Arto Leminen and Francesmary Modugno and Ness, {Roberta B} and Edwards, {Robert P} and Kelley, {Joseph L} and Florian Heitz and {du Bois}, Andreas and Philipp Harter and Ira Schwaab and Karlan, {Beth Y} and Jenny Lester and Sandra Orsulic and Rimel, {Bobbie J} and Kj{\ae}r, {Susanne K} and Estrid H{\o}gdall and Allan Jensen and H{\o}gdall, {Claus K} and Lene Lundvall and {Australian Ovarian Cancer Study Group}",
year = "2018",
doi = "10.1038/s41416-018-0011-3",
language = "English",
volume = "118",
pages = "1123--1129",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",
number = "8",

}

RIS

TY - JOUR

T1 - Adult height is associated with increased risk of ovarian cancer

T2 - a Mendelian randomisation study

AU - Dixon-Suen, Suzanne C

AU - Nagle, Christina M

AU - Thrift, Aaron P

AU - Pharoah, Paul D P

AU - Ewing, Ailith

AU - Pearce, Celeste Leigh

AU - Zheng, Wei

AU - Chenevix-Trench, Georgia

AU - Fasching, Peter A

AU - Beckmann, Matthias W

AU - Lambrechts, Diether

AU - Vergote, Ignace

AU - Lambrechts, Sandrina

AU - Van Nieuwenhuysen, Els

AU - Rossing, Mary Anne

AU - Doherty, Jennifer A

AU - Wicklund, Kristine G

AU - Chang-Claude, Jenny

AU - Jung, Audrey Y

AU - Moysich, Kirsten B

AU - Odunsi, Kunle

AU - Goodman, Marc T

AU - Wilkens, Lynne R

AU - Thompson, Pamela J

AU - Shvetsov, Yurii B

AU - Dörk, Thilo

AU - Park-Simon, Tjoung-Won

AU - Hillemanns, Peter

AU - Bogdanova, Natalia

AU - Butzow, Ralf

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M

AU - Leminen, Arto

AU - Modugno, Francesmary

AU - Ness, Roberta B

AU - Edwards, Robert P

AU - Kelley, Joseph L

AU - Heitz, Florian

AU - du Bois, Andreas

AU - Harter, Philipp

AU - Schwaab, Ira

AU - Karlan, Beth Y

AU - Lester, Jenny

AU - Orsulic, Sandra

AU - Rimel, Bobbie J

AU - Kjær, Susanne K

AU - Høgdall, Estrid

AU - Jensen, Allan

AU - Høgdall, Claus K

AU - Lundvall, Lene

AU - Australian Ovarian Cancer Study Group

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

AB - BACKGROUND: Observational studies suggest greater height is associated with increased ovarian cancer risk, but cannot exclude bias and/or confounding as explanations for this. Mendelian randomisation (MR) can provide evidence which may be less prone to bias.METHODS: We pooled data from 39 Ovarian Cancer Association Consortium studies (16,395 cases; 23,003 controls). We applied two-stage predictor-substitution MR, using a weighted genetic risk score combining 609 single-nucleotide polymorphisms. Study-specific odds ratios (OR) and 95% confidence intervals (CI) for the association between genetically predicted height and risk were pooled using random-effects meta-analysis.RESULTS: Greater genetically predicted height was associated with increased ovarian cancer risk overall (pooled-OR (pOR) = 1.06; 95% CI: 1.01-1.11 per 5 cm increase in height), and separately for invasive (pOR = 1.06; 95% CI: 1.01-1.11) and borderline (pOR = 1.15; 95% CI: 1.02-1.29) tumours.CONCLUSIONS: Women with a genetic propensity to being taller have increased risk of ovarian cancer. This suggests genes influencing height are involved in pathways promoting ovarian carcinogenesis.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Body Height/genetics

KW - Carcinoma, Ovarian Epithelial/epidemiology

KW - Case-Control Studies

KW - Female

KW - Genetic Predisposition to Disease

KW - Geography

KW - Humans

KW - Mendelian Randomization Analysis

KW - Middle Aged

KW - Ovarian Neoplasms/epidemiology

KW - Risk Factors

KW - Young Adult

U2 - 10.1038/s41416-018-0011-3

DO - 10.1038/s41416-018-0011-3

M3 - Journal article

C2 - 29555990

VL - 118

SP - 1123

EP - 1129

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

IS - 8

ER -

ID: 221758446