Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer

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Standard

Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. / Christensen, Maria V.; Høgdall, Claus; Jensen, Steffen G.; Lokman, Noor; Ricciardelli, Carmela; Christensen, Ib J.; Christiansen, Pernille; Brask, Julie; Karlsen, Mona A.; Nissen, Therese K.; Jochumsen, Kirsten M.; Høgdall, Estrid.

I: Anticancer Research, Bind 39, Nr. 5, 05.2019, s. 2475-2482.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Christensen, MV, Høgdall, C, Jensen, SG, Lokman, N, Ricciardelli, C, Christensen, IJ, Christiansen, P, Brask, J, Karlsen, MA, Nissen, TK, Jochumsen, KM & Høgdall, E 2019, 'Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer', Anticancer Research, bind 39, nr. 5, s. 2475-2482. https://doi.org/10.21873/anticanres.13367

APA

Christensen, M. V., Høgdall, C., Jensen, S. G., Lokman, N., Ricciardelli, C., Christensen, I. J., Christiansen, P., Brask, J., Karlsen, M. A., Nissen, T. K., Jochumsen, K. M., & Høgdall, E. (2019). Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. Anticancer Research, 39(5), 2475-2482. https://doi.org/10.21873/anticanres.13367

Vancouver

Christensen MV, Høgdall C, Jensen SG, Lokman N, Ricciardelli C, Christensen IJ o.a. Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. Anticancer Research. 2019 maj;39(5):2475-2482. https://doi.org/10.21873/anticanres.13367

Author

Christensen, Maria V. ; Høgdall, Claus ; Jensen, Steffen G. ; Lokman, Noor ; Ricciardelli, Carmela ; Christensen, Ib J. ; Christiansen, Pernille ; Brask, Julie ; Karlsen, Mona A. ; Nissen, Therese K. ; Jochumsen, Kirsten M. ; Høgdall, Estrid. / Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer. I: Anticancer Research. 2019 ; Bind 39, Nr. 5. s. 2475-2482.

Bibtex

@article{1503da946a53428a8c53e4fd93ae6f0e,
title = "Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer",
abstract = "Background/Aim: Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). Materials and Methods: Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity. Results: The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. Conclusion: High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.",
keywords = "Annexin A2, Biomarkers, EOC, Epithelial ovarian cancer, Immunohistochemistry, S100A10",
author = "Christensen, {Maria V.} and Claus H{\o}gdall and Jensen, {Steffen G.} and Noor Lokman and Carmela Ricciardelli and Christensen, {Ib J.} and Pernille Christiansen and Julie Brask and Karlsen, {Mona A.} and Nissen, {Therese K.} and Jochumsen, {Kirsten M.} and Estrid H{\o}gdall",
year = "2019",
month = may,
doi = "10.21873/anticanres.13367",
language = "English",
volume = "39",
pages = "2475--2482",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "5",

}

RIS

TY - JOUR

T1 - Annexin A2 and S100A10 as Candidate Prognostic Markers in Epithelial Ovarian Cancer

AU - Christensen, Maria V.

AU - Høgdall, Claus

AU - Jensen, Steffen G.

AU - Lokman, Noor

AU - Ricciardelli, Carmela

AU - Christensen, Ib J.

AU - Christiansen, Pernille

AU - Brask, Julie

AU - Karlsen, Mona A.

AU - Nissen, Therese K.

AU - Jochumsen, Kirsten M.

AU - Høgdall, Estrid

PY - 2019/5

Y1 - 2019/5

N2 - Background/Aim: Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). Materials and Methods: Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity. Results: The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. Conclusion: High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.

AB - Background/Aim: Ovarian cancer (OC) is the 5th most common cancer among European women. Approximately 70-80% of OC is diagnosed at advanced stage resulting in an elevated mortality rate. The aim of this study was to examine whether Annexin A2 and S100A10 expression can be used as prognostic markers for epithelial ovarian cancer (EOC). Materials and Methods: Expression of Annexin A2 and S100A10 was evaluated in EOC tissue samples (n=303) by immunohistochemistry. The staining of the membrane, cytoplasmic and stroma was assessed according to intensity. Results: The expression of both markers correlated to histological subtype, histological grading, International Federation of Gynecology and Obstetrics (FIGO) stage, and macro-radical surgery. Univariate Cox regression analysis showed that Annexin A2 and S100A10 in stromal tissue correlated with shorter overall survival (OS). Multivariate Cox regression analysis demonstrated no independent prognostic significance of stromal Annexin A2 expression. Conclusion: High expression of Annexin A2 and S100A10 in stromal tissue from EOC patients was associated with reduced OS; however, no independent prognostic value was found for any of the markers.

KW - Annexin A2

KW - Biomarkers

KW - EOC

KW - Epithelial ovarian cancer

KW - Immunohistochemistry

KW - S100A10

U2 - 10.21873/anticanres.13367

DO - 10.21873/anticanres.13367

M3 - Journal article

C2 - 31092442

AN - SCOPUS:85066441573

VL - 39

SP - 2475

EP - 2482

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 5

ER -

ID: 241575802