TY - JOUR

T1 - Assessment of moderate coffee consumption and risk of epithelial ovarian cancer

T2 - A Mendelian randomization study

AU - Ong, Jue Sheng

AU - Hwang, Liang Dar

AU - Cuellar-Partida, Gabriel

AU - Martin, Nicholas G.

AU - Chenevix-Trench, Georgia

AU - Quinn, Michael C.J.

AU - Cornelis, Marilyn C.

AU - Gharahkhani, Puya

AU - MWebb, Penelope

AU - MacGregor, Stuart

AU - Bryne, Enda

AU - Fasching, Peter A.

AU - Hein, Alexander

AU - Burghaus, Stefanie

AU - Beckmann, Matthias W.

AU - Lambrechts, Diether

AU - Van Nieuwenhuysen, Els

AU - Vergote, Ignace

AU - Vanderstichele, Adriaan

AU - Swerdlow, Anthony J.

AU - Jones, Michael

AU - Orr, Nicholas

AU - Schoemaker, Minouk

AU - Edwards, Digna Velez

AU - Brenton, James

AU - Benítez, Javier

AU - García, María J.

AU - Rodriguez-Antona, Cristina R.

AU - Rossing, Mary Anne

AU - Fortner, Renée T.

AU - Riboli, Elio

AU - Chang-Claude, Jenny

AU - Eilber, Ursula

AU - Wang-Gohrke, Shan

AU - Yannoukakos, Drakoulis

AU - Goodman, Marc T.

AU - Bogdanova, Natalia

AU - Dörk, Thilo

AU - Duerst, Matthias

AU - Hillemanns, Peter

AU - Runnebaum, Ingo B.

AU - Antonenkova, Natalia

AU - Butzow, Ralf

AU - Nevanlinna, Heli

AU - Pelttari, Liisa M.

AU - Edwards, Robert P.

AU - Kelley, Joseph L.

AU - Kjaer, Susanne K.

AU - Høgdall, Estrid

AU - Høgdall, Claus K.

AU - Ovarian Cancer Association Consortium

PY - 2018

Y1 - 2018

N2 - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

AB - Background: Coffee consumption has been shown to be associated with various health outcomes in observational studies. However, evidence for its association with epithelial ovarian cancer (EOC) is inconsistent and it is unclear whether these associations are causal. Methods: We used single nucleotide polymorphisms associated with (i) coffee and (ii) caffeine consumption to perform Mendelian randomization (MR) on EOC risk. We conducted a two-sample MR using genetic data on 44 062 individuals of European ancestry from the Ovarian Cancer Association Consortium (OCAC), and combined instrumental variable estimates using aWald-type ratio estimator. Results: For all EOC cases, the causal odds ratio (COR) for genetically predicted consumption of one additional cup of coffee per day was 0.92 [95% confidence interval (CI): 0.79, 1.06]. The COR was 0.90 (95% CI: 0.73, 1.10) for high-grade serous EOC. The COR for genetically predicted consumption of an additional 80mg caffeine was 1.01 (95% CI: 0.92, 1.11) for all EOC cases and 0.90 (95% CI: 0.73, 1.10) for high-grade serous cases. Conclusions: We found no evidence indicative of a strong association between EOC risk and genetically predicted coffee or caffeine levels. However, our estimates were not statistically inconsistent with earlier observational studies and we were unable to rule out small protective associations.

KW - Caffeine

KW - Causality

KW - Coffee

KW - Mendelian randomization

KW - Ovarian cancer

U2 - 10.1093/IJE/DYX236

DO - 10.1093/IJE/DYX236

M3 - Journal article

C2 - 29186515

AN - SCOPUS:85048363842

VL - 47

SP - 450

EP - 459

JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

IS - 2

ER -