Standard
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer. / Hampras, Shalaka S; Sucheston-Campbell, Lara E; Cannioto, Rikki; Chang-Claude, Jenny; Modugno, Francesmary; Doerk, Thilo; Hillemanns, Peter; Preus, Leah; Knutson, Keith L; Wallace, Paul K; Hong, Chi-chen; Friel, Grace; Davis, Warren; Nesline, Mary; Pearce, Celeste L; Kelemen, Linda E; Goodman, Marc T; Bandera, Elisa V; Terry, Kathryn L; Schoof, Nils; Eng, Kevin H; Clay, Alyssa I; Singh, Prashant K; Joseph, Janine M; Aben, Katja K H; Anton-Culver, Hoda; Antonenkova, Natalia; Baker, Helen; Bean, Yukie; Beckmann, Matthias W; Bisogna, Maria; Bjorge, Line; Bogdanova, Natalia; Brinton, Louise A; Brooks-Wilson, Angela; Bruinsma, Fiona; Butzow, Ralf; Campbell, Ian G; Carty, Karen; Cook, Linda S; Cramer, Daniel W; Cybulski, Cezary; Dansonka-Mieszkowska, Agnieszka; Dennis, Joe; Despierre, Evelyn; Dicks, Ed; Doherty, Jennifer A; Du Bois, Andreas; Durst, Matthias; Easton, Doug; Eccles, Diana; Edwards, Robert P; Ekici, Arif B; Fasching, Peter A; Fridley, Brooke L; Gao, Yu-Tang; Gentry-Maharaj, Aleksandra; Giles, Graham; Glasspool, Rosalind M; Gronwald, Jacek; Harrington, Patricia; Harter, Philipp; Hasmad, Hanis Nazihah; Hein, Alexander; Heitz, Florian; Hildebrandt, Michelle A T; Hogdall, Claus; Hogdall, Estrid; Hosono, Satoyo; Iversen, Edwin S; Jakubowska, Anna; Jensen, Allan; Ji, Bu-Tian; Karlan, Beth Y; Kellar, Melissa; Kelley, Joseph L; Kiemeney, Lambertus A; Klapdor, Rüdiger; Kolomeyevskaya, Nonna; Krakstad, Camilla; Kjaer, Susanne K; Kruszka, Bridget; Kupryjanczyk, Jolanta; Lambrechts, Diether; Lambrechts, Sandrina; Le, Nhu D; Lee, Alice W; Lele, Shashikant; Leminen, Arto; Lester, Jenny; Levine, Douglas A; Liang, Dong; Lissowska, Jolanta; Liu, Song; Lu, Karen; Lubinski, Jan; Lundvall, Lene; Massuger, Leon F A G; Matsuo, Keitaro; McGuire, Valeria; McLaughlin, John R; McNeish, Ian; Menon, Usha; Moes-Sosnowska, Joanna; Narod, Steven A; Nedergaard, Lotte; Nevanlinna, Heli; Nickels, Stefan; Olson, Sara H; Orlow, Irene; Weber, Rachel Palmieri; Paul, James; Pejovic, Tanja; Pelttari, Liisa M; Perkins, Barbara; Permuth-Wey, Jenny; Pike, Malcolm C; Plisiecka-Halasa, Joanna; Poole, Elizabeth M; Risch, Harvey A; Rossing, Mary Anne; Rothstein, Joseph H; Rudolph, Anja; Runnebaum, Ingo B; Rzepecka, Iwona K; Salvesen, Helga B; Schernhammer, Eva; Schmitt, Kristina; Schwaab, Ira; Shu, Xiao-Ou; Shvetsov, Yurii B; Siddiqui, Nadeem; Sieh, Weiva; Song, Honglin; Southey, Melissa C; Tangen, Ingvild L; Teo, Soo-Hwang; Thompson, Pamela J; Timorek, Agnieszka; Tsai, Ya-Yu; Tworoger, Shelley S; Tyrer, Jonathan; van Altena, Anna M; Vergote, Ignace; Vierkant, Robert A; Walsh, Christine; Wang-Gohrke, Shan; Wentzensen, Nicolas; Whittemore, Alice S; Wicklund, Kristine G; Wilkens, Lynne R; Wu, Anna H; Wu, Xifeng; Woo, Yin Ling; Yang, Hannah; Zheng, Wei; Ziogas, Argyrios; Gayther, Simon A; Ramus, Susan J; Sellers, Thomas A; Schildkraut, Joellen M; Phelan, Catherine M; Berchuck, Andrew; Chenevix-Trench, Georgia; Cunningham, Julie M; Pharoah, Paul; Ness, Roberta B; Odunsi, Kunle; Goode, Ellen L; Moysich, Kirsten B.
I:
OncoTarget, Bind 7, Nr. 43, 2016, s. 69097-69110.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Hampras, SS, Sucheston-Campbell, LE, Cannioto, R, Chang-Claude, J, Modugno, F, Doerk, T, Hillemanns, P, Preus, L, Knutson, KL, Wallace, PK, Hong, C, Friel, G, Davis, W, Nesline, M, Pearce, CL, Kelemen, LE, Goodman, MT, Bandera, EV, Terry, KL, Schoof, N, Eng, KH, Clay, AI, Singh, PK, Joseph, JM, Aben, KKH, Anton-Culver, H, Antonenkova, N, Baker, H, Bean, Y, Beckmann, MW, Bisogna, M, Bjorge, L, Bogdanova, N, Brinton, LA, Brooks-Wilson, A, Bruinsma, F, Butzow, R, Campbell, IG, Carty, K, Cook, LS, Cramer, DW, Cybulski, C, Dansonka-Mieszkowska, A, Dennis, J, Despierre, E, Dicks, E, Doherty, JA, Du Bois, A, Durst, M, Easton, D, Eccles, D, Edwards, RP, Ekici, AB, Fasching, PA, Fridley, BL, Gao, Y-T, Gentry-Maharaj, A, Giles, G, Glasspool, RM, Gronwald, J, Harrington, P, Harter, P, Hasmad, HN, Hein, A, Heitz, F, Hildebrandt, MAT
, Hogdall, C, Hogdall, E, Hosono, S, Iversen, ES, Jakubowska, A, Jensen, A, Ji, B-T, Karlan, BY, Kellar, M, Kelley, JL, Kiemeney, LA, Klapdor, R, Kolomeyevskaya, N, Krakstad, C
, Kjaer, SK, Kruszka, B, Kupryjanczyk, J, Lambrechts, D, Lambrechts, S, Le, ND, Lee, AW, Lele, S, Leminen, A, Lester, J, Levine, DA, Liang, D, Lissowska, J, Liu, S, Lu, K, Lubinski, J, Lundvall, L, Massuger, LFAG, Matsuo, K, McGuire, V, McLaughlin, JR, McNeish, I, Menon, U, Moes-Sosnowska, J, Narod, SA, Nedergaard, L, Nevanlinna, H, Nickels, S, Olson, SH, Orlow, I, Weber, RP, Paul, J, Pejovic, T, Pelttari, LM, Perkins, B, Permuth-Wey, J, Pike, MC, Plisiecka-Halasa, J, Poole, EM, Risch, HA, Rossing, MA, Rothstein, JH, Rudolph, A, Runnebaum, IB, Rzepecka, IK, Salvesen, HB, Schernhammer, E, Schmitt, K, Schwaab, I, Shu, X-O, Shvetsov, YB, Siddiqui, N, Sieh, W, Song, H, Southey, MC, Tangen, IL, Teo, S-H, Thompson, PJ, Timorek, A, Tsai, Y-Y, Tworoger, SS, Tyrer, J, van Altena, AM, Vergote, I, Vierkant, RA, Walsh, C, Wang-Gohrke, S, Wentzensen, N, Whittemore, AS, Wicklund, KG, Wilkens, LR, Wu, AH, Wu, X, Woo, YL, Yang, H, Zheng, W, Ziogas, A, Gayther, SA, Ramus, SJ, Sellers, TA, Schildkraut, JM, Phelan, CM, Berchuck, A, Chenevix-Trench, G, Cunningham, JM, Pharoah, P, Ness, RB, Odunsi, K, Goode, EL & Moysich, KB 2016, '
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer',
OncoTarget, bind 7, nr. 43, s. 69097-69110.
https://doi.org/10.18632/oncotarget.10215APA
Hampras, S. S., Sucheston-Campbell, L. E., Cannioto, R., Chang-Claude, J., Modugno, F., Doerk, T., Hillemanns, P., Preus, L., Knutson, K. L., Wallace, P. K., Hong, C., Friel, G., Davis, W., Nesline, M., Pearce, C. L., Kelemen, L. E., Goodman, M. T., Bandera, E. V., Terry, K. L., ... Moysich, K. B. (2016).
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
OncoTarget,
7(43), 69097-69110.
https://doi.org/10.18632/oncotarget.10215Vancouver
Hampras SS, Sucheston-Campbell LE, Cannioto R, Chang-Claude J, Modugno F, Doerk T o.a.
Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer.
OncoTarget. 2016;7(43):69097-69110.
https://doi.org/10.18632/oncotarget.10215Author
Hampras, Shalaka S ; Sucheston-Campbell, Lara E ; Cannioto, Rikki ; Chang-Claude, Jenny ; Modugno, Francesmary ; Doerk, Thilo ; Hillemanns, Peter ; Preus, Leah ; Knutson, Keith L ; Wallace, Paul K ; Hong, Chi-chen ; Friel, Grace ; Davis, Warren ; Nesline, Mary ; Pearce, Celeste L ; Kelemen, Linda E ; Goodman, Marc T ; Bandera, Elisa V ; Terry, Kathryn L ; Schoof, Nils ; Eng, Kevin H ; Clay, Alyssa I ; Singh, Prashant K ; Joseph, Janine M ; Aben, Katja K H ; Anton-Culver, Hoda ; Antonenkova, Natalia ; Baker, Helen ; Bean, Yukie ; Beckmann, Matthias W ; Bisogna, Maria ; Bjorge, Line ; Bogdanova, Natalia ; Brinton, Louise A ; Brooks-Wilson, Angela ; Bruinsma, Fiona ; Butzow, Ralf ; Campbell, Ian G ; Carty, Karen ; Cook, Linda S ; Cramer, Daniel W ; Cybulski, Cezary ; Dansonka-Mieszkowska, Agnieszka ; Dennis, Joe ; Despierre, Evelyn ; Dicks, Ed ; Doherty, Jennifer A ; Du Bois, Andreas ; Durst, Matthias ; Easton, Doug ; Eccles, Diana ; Edwards, Robert P ; Ekici, Arif B ; Fasching, Peter A ; Fridley, Brooke L ; Gao, Yu-Tang ; Gentry-Maharaj, Aleksandra ; Giles, Graham ; Glasspool, Rosalind M ; Gronwald, Jacek ; Harrington, Patricia ; Harter, Philipp ; Hasmad, Hanis Nazihah ; Hein, Alexander ; Heitz, Florian ; Hildebrandt, Michelle A T ; Hogdall, Claus ; Hogdall, Estrid ; Hosono, Satoyo ; Iversen, Edwin S ; Jakubowska, Anna ; Jensen, Allan ; Ji, Bu-Tian ; Karlan, Beth Y ; Kellar, Melissa ; Kelley, Joseph L ; Kiemeney, Lambertus A ; Klapdor, Rüdiger ; Kolomeyevskaya, Nonna ; Krakstad, Camilla ; Kjaer, Susanne K ; Kruszka, Bridget ; Kupryjanczyk, Jolanta ; Lambrechts, Diether ; Lambrechts, Sandrina ; Le, Nhu D ; Lee, Alice W ; Lele, Shashikant ; Leminen, Arto ; Lester, Jenny ; Levine, Douglas A ; Liang, Dong ; Lissowska, Jolanta ; Liu, Song ; Lu, Karen ; Lubinski, Jan ; Lundvall, Lene ; Massuger, Leon F A G ; Matsuo, Keitaro ; McGuire, Valeria ; McLaughlin, John R ; McNeish, Ian ; Menon, Usha ; Moes-Sosnowska, Joanna ; Narod, Steven A ; Nedergaard, Lotte ; Nevanlinna, Heli ; Nickels, Stefan ; Olson, Sara H ; Orlow, Irene ; Weber, Rachel Palmieri ; Paul, James ; Pejovic, Tanja ; Pelttari, Liisa M ; Perkins, Barbara ; Permuth-Wey, Jenny ; Pike, Malcolm C ; Plisiecka-Halasa, Joanna ; Poole, Elizabeth M ; Risch, Harvey A ; Rossing, Mary Anne ; Rothstein, Joseph H ; Rudolph, Anja ; Runnebaum, Ingo B ; Rzepecka, Iwona K ; Salvesen, Helga B ; Schernhammer, Eva ; Schmitt, Kristina ; Schwaab, Ira ; Shu, Xiao-Ou ; Shvetsov, Yurii B ; Siddiqui, Nadeem ; Sieh, Weiva ; Song, Honglin ; Southey, Melissa C ; Tangen, Ingvild L ; Teo, Soo-Hwang ; Thompson, Pamela J ; Timorek, Agnieszka ; Tsai, Ya-Yu ; Tworoger, Shelley S ; Tyrer, Jonathan ; van Altena, Anna M ; Vergote, Ignace ; Vierkant, Robert A ; Walsh, Christine ; Wang-Gohrke, Shan ; Wentzensen, Nicolas ; Whittemore, Alice S ; Wicklund, Kristine G ; Wilkens, Lynne R ; Wu, Anna H ; Wu, Xifeng ; Woo, Yin Ling ; Yang, Hannah ; Zheng, Wei ; Ziogas, Argyrios ; Gayther, Simon A ; Ramus, Susan J ; Sellers, Thomas A ; Schildkraut, Joellen M ; Phelan, Catherine M ; Berchuck, Andrew ; Chenevix-Trench, Georgia ; Cunningham, Julie M ; Pharoah, Paul ; Ness, Roberta B ; Odunsi, Kunle ; Goode, Ellen L ; Moysich, Kirsten B. / Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer. I: OncoTarget. 2016 ; Bind 7, Nr. 43. s. 69097-69110.
Bibtex
@article{0f0b4a02b2f641ecb9dbfca6c7089aa5,
title = "Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer",
abstract = "BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.",
keywords = "Journal Article",
author = "Hampras, {Shalaka S} and Sucheston-Campbell, {Lara E} and Rikki Cannioto and Jenny Chang-Claude and Francesmary Modugno and Thilo Doerk and Peter Hillemanns and Leah Preus and Knutson, {Keith L} and Wallace, {Paul K} and Chi-chen Hong and Grace Friel and Warren Davis and Mary Nesline and Pearce, {Celeste L} and Kelemen, {Linda E} and Goodman, {Marc T} and Bandera, {Elisa V} and Terry, {Kathryn L} and Nils Schoof and Eng, {Kevin H} and Clay, {Alyssa I} and Singh, {Prashant K} and Joseph, {Janine M} and Aben, {Katja K H} and Hoda Anton-Culver and Natalia Antonenkova and Helen Baker and Yukie Bean and Beckmann, {Matthias W} and Maria Bisogna and Line Bjorge and Natalia Bogdanova and Brinton, {Louise A} and Angela Brooks-Wilson and Fiona Bruinsma and Ralf Butzow and Campbell, {Ian G} and Karen Carty and Cook, {Linda S} and Cramer, {Daniel W} and Cezary Cybulski and Agnieszka Dansonka-Mieszkowska and Joe Dennis and Evelyn Despierre and Ed Dicks and Doherty, {Jennifer A} and {Du Bois}, Andreas and Matthias Durst and Doug Easton and Diana Eccles and Edwards, {Robert P} and Ekici, {Arif B} and Fasching, {Peter A} and Fridley, {Brooke L} and Yu-Tang Gao and Aleksandra Gentry-Maharaj and Graham Giles and Glasspool, {Rosalind M} and Jacek Gronwald and Patricia Harrington and Philipp Harter and Hasmad, {Hanis Nazihah} and Alexander Hein and Florian Heitz and Hildebrandt, {Michelle A T} and Claus Hogdall and Estrid Hogdall and Satoyo Hosono and Iversen, {Edwin S} and Anna Jakubowska and Allan Jensen and Bu-Tian Ji and Karlan, {Beth Y} and Melissa Kellar and Kelley, {Joseph L} and Kiemeney, {Lambertus A} and R{\"u}diger Klapdor and Nonna Kolomeyevskaya and Camilla Krakstad and Kjaer, {Susanne K} and Bridget Kruszka and Jolanta Kupryjanczyk and Diether Lambrechts and Sandrina Lambrechts and Le, {Nhu D} and Lee, {Alice W} and Shashikant Lele and Arto Leminen and Jenny Lester and Levine, {Douglas A} and Dong Liang and Jolanta Lissowska and Song Liu and Karen Lu and Jan Lubinski and Lene Lundvall and Massuger, {Leon F A G} and Keitaro Matsuo and Valeria McGuire and McLaughlin, {John R} and Ian McNeish and Usha Menon and Joanna Moes-Sosnowska and Narod, {Steven A} and Lotte Nedergaard and Heli Nevanlinna and Stefan Nickels and Olson, {Sara H} and Irene Orlow and Weber, {Rachel Palmieri} and James Paul and Tanja Pejovic and Pelttari, {Liisa M} and Barbara Perkins and Jenny Permuth-Wey and Pike, {Malcolm C} and Joanna Plisiecka-Halasa and Poole, {Elizabeth M} and Risch, {Harvey A} and Rossing, {Mary Anne} and Rothstein, {Joseph H} and Anja Rudolph and Runnebaum, {Ingo B} and Rzepecka, {Iwona K} and Salvesen, {Helga B} and Eva Schernhammer and Kristina Schmitt and Ira Schwaab and Xiao-Ou Shu and Shvetsov, {Yurii B} and Nadeem Siddiqui and Weiva Sieh and Honglin Song and Southey, {Melissa C} and Tangen, {Ingvild L} and Soo-Hwang Teo and Thompson, {Pamela J} and Agnieszka Timorek and Ya-Yu Tsai and Tworoger, {Shelley S} and Jonathan Tyrer and {van Altena}, {Anna M} and Ignace Vergote and Vierkant, {Robert A} and Christine Walsh and Shan Wang-Gohrke and Nicolas Wentzensen and Whittemore, {Alice S} and Wicklund, {Kristine G} and Wilkens, {Lynne R} and Wu, {Anna H} and Xifeng Wu and Woo, {Yin Ling} and Hannah Yang and Wei Zheng and Argyrios Ziogas and Gayther, {Simon A} and Ramus, {Susan J} and Sellers, {Thomas A} and Schildkraut, {Joellen M} and Phelan, {Catherine M} and Andrew Berchuck and Georgia Chenevix-Trench and Cunningham, {Julie M} and Paul Pharoah and Ness, {Roberta B} and Kunle Odunsi and Goode, {Ellen L} and Moysich, {Kirsten B}",
year = "2016",
doi = "10.18632/oncotarget.10215",
language = "English",
volume = "7",
pages = "69097--69110",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "43",
}
RIS
TY - JOUR
T1 - Assessment of variation in immunosuppressive pathway genes reveals TGFBR2 to be associated with risk of clear cell ovarian cancer
AU - Hampras, Shalaka S
AU - Sucheston-Campbell, Lara E
AU - Cannioto, Rikki
AU - Chang-Claude, Jenny
AU - Modugno, Francesmary
AU - Doerk, Thilo
AU - Hillemanns, Peter
AU - Preus, Leah
AU - Knutson, Keith L
AU - Wallace, Paul K
AU - Hong, Chi-chen
AU - Friel, Grace
AU - Davis, Warren
AU - Nesline, Mary
AU - Pearce, Celeste L
AU - Kelemen, Linda E
AU - Goodman, Marc T
AU - Bandera, Elisa V
AU - Terry, Kathryn L
AU - Schoof, Nils
AU - Eng, Kevin H
AU - Clay, Alyssa I
AU - Singh, Prashant K
AU - Joseph, Janine M
AU - Aben, Katja K H
AU - Anton-Culver, Hoda
AU - Antonenkova, Natalia
AU - Baker, Helen
AU - Bean, Yukie
AU - Beckmann, Matthias W
AU - Bisogna, Maria
AU - Bjorge, Line
AU - Bogdanova, Natalia
AU - Brinton, Louise A
AU - Brooks-Wilson, Angela
AU - Bruinsma, Fiona
AU - Butzow, Ralf
AU - Campbell, Ian G
AU - Carty, Karen
AU - Cook, Linda S
AU - Cramer, Daniel W
AU - Cybulski, Cezary
AU - Dansonka-Mieszkowska, Agnieszka
AU - Dennis, Joe
AU - Despierre, Evelyn
AU - Dicks, Ed
AU - Doherty, Jennifer A
AU - Du Bois, Andreas
AU - Durst, Matthias
AU - Easton, Doug
AU - Eccles, Diana
AU - Edwards, Robert P
AU - Ekici, Arif B
AU - Fasching, Peter A
AU - Fridley, Brooke L
AU - Gao, Yu-Tang
AU - Gentry-Maharaj, Aleksandra
AU - Giles, Graham
AU - Glasspool, Rosalind M
AU - Gronwald, Jacek
AU - Harrington, Patricia
AU - Harter, Philipp
AU - Hasmad, Hanis Nazihah
AU - Hein, Alexander
AU - Heitz, Florian
AU - Hildebrandt, Michelle A T
AU - Hogdall, Claus
AU - Hogdall, Estrid
AU - Hosono, Satoyo
AU - Iversen, Edwin S
AU - Jakubowska, Anna
AU - Jensen, Allan
AU - Ji, Bu-Tian
AU - Karlan, Beth Y
AU - Kellar, Melissa
AU - Kelley, Joseph L
AU - Kiemeney, Lambertus A
AU - Klapdor, Rüdiger
AU - Kolomeyevskaya, Nonna
AU - Krakstad, Camilla
AU - Kjaer, Susanne K
AU - Kruszka, Bridget
AU - Kupryjanczyk, Jolanta
AU - Lambrechts, Diether
AU - Lambrechts, Sandrina
AU - Le, Nhu D
AU - Lee, Alice W
AU - Lele, Shashikant
AU - Leminen, Arto
AU - Lester, Jenny
AU - Levine, Douglas A
AU - Liang, Dong
AU - Lissowska, Jolanta
AU - Liu, Song
AU - Lu, Karen
AU - Lubinski, Jan
AU - Lundvall, Lene
AU - Massuger, Leon F A G
AU - Matsuo, Keitaro
AU - McGuire, Valeria
AU - McLaughlin, John R
AU - McNeish, Ian
AU - Menon, Usha
AU - Moes-Sosnowska, Joanna
AU - Narod, Steven A
AU - Nedergaard, Lotte
AU - Nevanlinna, Heli
AU - Nickels, Stefan
AU - Olson, Sara H
AU - Orlow, Irene
AU - Weber, Rachel Palmieri
AU - Paul, James
AU - Pejovic, Tanja
AU - Pelttari, Liisa M
AU - Perkins, Barbara
AU - Permuth-Wey, Jenny
AU - Pike, Malcolm C
AU - Plisiecka-Halasa, Joanna
AU - Poole, Elizabeth M
AU - Risch, Harvey A
AU - Rossing, Mary Anne
AU - Rothstein, Joseph H
AU - Rudolph, Anja
AU - Runnebaum, Ingo B
AU - Rzepecka, Iwona K
AU - Salvesen, Helga B
AU - Schernhammer, Eva
AU - Schmitt, Kristina
AU - Schwaab, Ira
AU - Shu, Xiao-Ou
AU - Shvetsov, Yurii B
AU - Siddiqui, Nadeem
AU - Sieh, Weiva
AU - Song, Honglin
AU - Southey, Melissa C
AU - Tangen, Ingvild L
AU - Teo, Soo-Hwang
AU - Thompson, Pamela J
AU - Timorek, Agnieszka
AU - Tsai, Ya-Yu
AU - Tworoger, Shelley S
AU - Tyrer, Jonathan
AU - van Altena, Anna M
AU - Vergote, Ignace
AU - Vierkant, Robert A
AU - Walsh, Christine
AU - Wang-Gohrke, Shan
AU - Wentzensen, Nicolas
AU - Whittemore, Alice S
AU - Wicklund, Kristine G
AU - Wilkens, Lynne R
AU - Wu, Anna H
AU - Wu, Xifeng
AU - Woo, Yin Ling
AU - Yang, Hannah
AU - Zheng, Wei
AU - Ziogas, Argyrios
AU - Gayther, Simon A
AU - Ramus, Susan J
AU - Sellers, Thomas A
AU - Schildkraut, Joellen M
AU - Phelan, Catherine M
AU - Berchuck, Andrew
AU - Chenevix-Trench, Georgia
AU - Cunningham, Julie M
AU - Pharoah, Paul
AU - Ness, Roberta B
AU - Odunsi, Kunle
AU - Goode, Ellen L
AU - Moysich, Kirsten B
PY - 2016
Y1 - 2016
N2 - BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
AB - BACKGROUND: Regulatory T (Treg) cells, a subset of CD4+ T lymphocytes, are mediators of immunosuppression in cancer, and, thus, variants in genes encoding Treg cell immune molecules could be associated with ovarian cancer.METHODS: In a population of 15,596 epithelial ovarian cancer (EOC) cases and 23,236 controls, we measured genetic associations of 1,351 SNPs in Treg cell pathway genes with odds of ovarian cancer and tested pathway and gene-level associations, overall and by histotype, for the 25 genes, using the admixture likelihood (AML) method. The most significant single SNP associations were tested for correlation with expression levels in 44 ovarian cancer patients.RESULTS: The most significant global associations for all genes in the pathway were seen in endometrioid ( p = 0.082) and clear cell ( p = 0.083), with the most significant gene level association seen with TGFBR2 ( p = 0.001) and clear cell EOC. Gene associations with histotypes at p < 0.05 included: IL12 ( p = 0.005 and p = 0.008, serous and high-grade serous, respectively), IL8RA ( p = 0.035, endometrioid and mucinous), LGALS1 ( p = 0.03, mucinous), STAT5B ( p = 0.022, clear cell), TGFBR1 ( p = 0.021 endometrioid) and TGFBR2 ( p = 0.017 and p = 0.025, endometrioid and mucinous, respectively).CONCLUSIONS: Common inherited gene variation in Treg cell pathways shows some evidence of germline genetic contribution to odds of EOC that varies by histologic subtype and may be associated with mRNA expression of immune-complex receptor in EOC patients.
KW - Journal Article
U2 - 10.18632/oncotarget.10215
DO - 10.18632/oncotarget.10215
M3 - Journal article
C2 - 27533245
VL - 7
SP - 69097
EP - 69110
JO - Oncotarget
JF - Oncotarget
SN - 1949-2553
IS - 43
ER -
