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Common variants at 19p13 are associated with susceptibility to ovarian cancer. / Bolton, Kelly L; Tyrer, Jonathan; Song, Honglin; Ramus, Susan J; Notaridou, Maria; Jones, Chris; Sher, Tanya; Gentry-Maharaj, Aleksandra; Wozniak, Eva; Tsai, Ya-Yu; Weidhaas, Joanne; Paik, Daniel; Van Den Berg, David J; Stram, Daniel O; Pearce, Celeste Leigh; Wu, Anna H; Brewster, Wendy; Anton-Culver, Hoda; Ziogas, Argyrios; Narod, Steven A; Levine, Douglas A; Kaye, Stanley B; Brown, Robert; Paul, Jim; Flanagan, James; Sieh, Weiva; McGuire, Valerie; Whittemore, Alice S; Campbell, Ian; Gore, Martin E; Lissowska, Jolanta; Yang, Hanna P; Medrek, Krzysztof; Gronwald, Jacek; Lubinski, Jan; Jakubowska, Anna; Le, Nhu D; Cook, Linda S; Kelemen, Linda E; Brook-Wilson, Angela; Massuger, Leon F A G; Kiemeney, Lambertus A; Aben, Katja K H; van Altena, Anne M; Houlston, Richard; Tomlinson, Ian; Palmieri, Rachel T; Moorman, Patricia G; Høgdall, Estrid Vilma Solyom; Hogdall, Claus; Australian Ovarian Cancer Study Group.
I:
Nature Genetics, Bind 42, Nr. 10, 01.10.2010, s. 880-4.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Bolton, KL, Tyrer, J, Song, H, Ramus, SJ, Notaridou, M, Jones, C, Sher, T, Gentry-Maharaj, A, Wozniak, E, Tsai, Y-Y, Weidhaas, J, Paik, D, Van Den Berg, DJ, Stram, DO, Pearce, CL, Wu, AH, Brewster, W, Anton-Culver, H, Ziogas, A, Narod, SA, Levine, DA, Kaye, SB, Brown, R, Paul, J, Flanagan, J, Sieh, W, McGuire, V, Whittemore, AS, Campbell, I, Gore, ME, Lissowska, J, Yang, HP, Medrek, K, Gronwald, J, Lubinski, J, Jakubowska, A, Le, ND, Cook, LS, Kelemen, LE, Brook-Wilson, A, Massuger, LFAG, Kiemeney, LA, Aben, KKH, van Altena, AM, Houlston, R, Tomlinson, I, Palmieri, RT, Moorman, PG
, Høgdall, EVS, Hogdall, C & Australian Ovarian Cancer Study Group 2010, '
Common variants at 19p13 are associated with susceptibility to ovarian cancer',
Nature Genetics, bind 42, nr. 10, s. 880-4.
https://doi.org/10.1038/ng.666APA
Bolton, K. L., Tyrer, J., Song, H., Ramus, S. J., Notaridou, M., Jones, C., Sher, T., Gentry-Maharaj, A., Wozniak, E., Tsai, Y-Y., Weidhaas, J., Paik, D., Van Den Berg, D. J., Stram, D. O., Pearce, C. L., Wu, A. H., Brewster, W., Anton-Culver, H., Ziogas, A., ... Australian Ovarian Cancer Study Group (2010).
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Nature Genetics,
42(10), 880-4.
https://doi.org/10.1038/ng.666Vancouver
Bolton KL, Tyrer J, Song H, Ramus SJ, Notaridou M, Jones C o.a.
Common variants at 19p13 are associated with susceptibility to ovarian cancer.
Nature Genetics. 2010 okt. 1;42(10):880-4.
https://doi.org/10.1038/ng.666Author
Bolton, Kelly L ; Tyrer, Jonathan ; Song, Honglin ; Ramus, Susan J ; Notaridou, Maria ; Jones, Chris ; Sher, Tanya ; Gentry-Maharaj, Aleksandra ; Wozniak, Eva ; Tsai, Ya-Yu ; Weidhaas, Joanne ; Paik, Daniel ; Van Den Berg, David J ; Stram, Daniel O ; Pearce, Celeste Leigh ; Wu, Anna H ; Brewster, Wendy ; Anton-Culver, Hoda ; Ziogas, Argyrios ; Narod, Steven A ; Levine, Douglas A ; Kaye, Stanley B ; Brown, Robert ; Paul, Jim ; Flanagan, James ; Sieh, Weiva ; McGuire, Valerie ; Whittemore, Alice S ; Campbell, Ian ; Gore, Martin E ; Lissowska, Jolanta ; Yang, Hanna P ; Medrek, Krzysztof ; Gronwald, Jacek ; Lubinski, Jan ; Jakubowska, Anna ; Le, Nhu D ; Cook, Linda S ; Kelemen, Linda E ; Brook-Wilson, Angela ; Massuger, Leon F A G ; Kiemeney, Lambertus A ; Aben, Katja K H ; van Altena, Anne M ; Houlston, Richard ; Tomlinson, Ian ; Palmieri, Rachel T ; Moorman, Patricia G ; Høgdall, Estrid Vilma Solyom ; Hogdall, Claus ; Australian Ovarian Cancer Study Group. / Common variants at 19p13 are associated with susceptibility to ovarian cancer. I: Nature Genetics. 2010 ; Bind 42, Nr. 10. s. 880-4.
Bibtex
@article{94ee158a82f74c27a48d545766b69ea0,
title = "Common variants at 19p13 are associated with susceptibility to ovarian cancer",
abstract = "Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.",
author = "Bolton, {Kelly L} and Jonathan Tyrer and Honglin Song and Ramus, {Susan J} and Maria Notaridou and Chris Jones and Tanya Sher and Aleksandra Gentry-Maharaj and Eva Wozniak and Ya-Yu Tsai and Joanne Weidhaas and Daniel Paik and {Van Den Berg}, {David J} and Stram, {Daniel O} and Pearce, {Celeste Leigh} and Wu, {Anna H} and Wendy Brewster and Hoda Anton-Culver and Argyrios Ziogas and Narod, {Steven A} and Levine, {Douglas A} and Kaye, {Stanley B} and Robert Brown and Jim Paul and James Flanagan and Weiva Sieh and Valerie McGuire and Whittemore, {Alice S} and Ian Campbell and Gore, {Martin E} and Jolanta Lissowska and Yang, {Hanna P} and Krzysztof Medrek and Jacek Gronwald and Jan Lubinski and Anna Jakubowska and Le, {Nhu D} and Cook, {Linda S} and Kelemen, {Linda E} and Angela Brook-Wilson and Massuger, {Leon F A G} and Kiemeney, {Lambertus A} and Aben, {Katja K H} and {van Altena}, {Anne M} and Richard Houlston and Ian Tomlinson and Palmieri, {Rachel T} and Moorman, {Patricia G} and H{\o}gdall, {Estrid Vilma Solyom} and Claus Hogdall and H{\o}gdall, {Claus Kim}",
year = "2010",
month = oct,
day = "1",
doi = "http://dx.doi.org/10.1038/ng.666",
language = "English",
volume = "42",
pages = "880--4",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "10",
}
RIS
TY - JOUR
T1 - Common variants at 19p13 are associated with susceptibility to ovarian cancer
AU - Bolton, Kelly L
AU - Tyrer, Jonathan
AU - Song, Honglin
AU - Ramus, Susan J
AU - Notaridou, Maria
AU - Jones, Chris
AU - Sher, Tanya
AU - Gentry-Maharaj, Aleksandra
AU - Wozniak, Eva
AU - Tsai, Ya-Yu
AU - Weidhaas, Joanne
AU - Paik, Daniel
AU - Van Den Berg, David J
AU - Stram, Daniel O
AU - Pearce, Celeste Leigh
AU - Wu, Anna H
AU - Brewster, Wendy
AU - Anton-Culver, Hoda
AU - Ziogas, Argyrios
AU - Narod, Steven A
AU - Levine, Douglas A
AU - Kaye, Stanley B
AU - Brown, Robert
AU - Paul, Jim
AU - Flanagan, James
AU - Sieh, Weiva
AU - McGuire, Valerie
AU - Whittemore, Alice S
AU - Campbell, Ian
AU - Gore, Martin E
AU - Lissowska, Jolanta
AU - Yang, Hanna P
AU - Medrek, Krzysztof
AU - Gronwald, Jacek
AU - Lubinski, Jan
AU - Jakubowska, Anna
AU - Le, Nhu D
AU - Cook, Linda S
AU - Kelemen, Linda E
AU - Brook-Wilson, Angela
AU - Massuger, Leon F A G
AU - Kiemeney, Lambertus A
AU - Aben, Katja K H
AU - van Altena, Anne M
AU - Houlston, Richard
AU - Tomlinson, Ian
AU - Palmieri, Rachel T
AU - Moorman, Patricia G
AU - Høgdall, Estrid Vilma Solyom
AU - Hogdall, Claus
AU - Australian Ovarian Cancer Study Group
PY - 2010/10/1
Y1 - 2010/10/1
N2 - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
AB - Epithelial ovarian cancer (EOC) is the leading cause of death from gynecological malignancy in the developed world, accounting for 4% of the deaths from cancer in women. We performed a three-phase genome-wide association study of EOC survival in 8,951 individuals with EOC (cases) with available survival time data and a parallel association analysis of EOC susceptibility. Two SNPs at 19p13.11, rs8170 and rs2363956, showed evidence of association with survival (overall P = 5 × 10¿4 and P = 6 × 10¿4, respectively), but they did not replicate in phase 3. However, the same two SNPs demonstrated genome-wide significance for risk of serous EOC (P = 3 × 10¿¿ and P = 4 × 10¿¹¹, respectively). Expression analysis of candidate genes at this locus in ovarian tumors supported a role for the BRCA1-interacting gene C19orf62, also known as MERIT40, which contains rs8170, in EOC development.
U2 - http://dx.doi.org/10.1038/ng.666
DO - http://dx.doi.org/10.1038/ng.666
M3 - Journal article
VL - 42
SP - 880
EP - 884
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -
