Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer: A Danish Register Study
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Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer : A Danish Register Study. / Kristensen, Anne Bjerrum; Hare-Bruun, Helle; Høgdall, Claus Kim; Rudnicki, Martin.
I: International Journal of Gynecological Cancer, Bind 27, Nr. 2, 02.2017, s. 281-288.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Influence of Body Mass Index on Tumor Pathology and Survival in Uterine Cancer
T2 - A Danish Register Study
AU - Kristensen, Anne Bjerrum
AU - Hare-Bruun, Helle
AU - Høgdall, Claus Kim
AU - Rudnicki, Martin
PY - 2017/2
Y1 - 2017/2
N2 - OBJECTIVE: To evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer.DESIGN: Register study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003).MAIN OUTCOME MEASURES: Impact of BMI on type I and II endometrial cancer survival.MATERIALS AND METHODS: Danish Gynecological Cancer Database data on women with type I and II endometrial cancer were retrieved. Kaplan-Meier plot was used to illustrate differences in survival in relation to BMI. Log-rank test was used to demonstrate difference between the curves. Cox regression hazard model was used to estimate hazard ratios (HR) of the effect of BMI on overall survival.RESULTS: Four thousand three hundred thirty women were included. Women with type I cancer had a significantly better overall survival compared with those with type II cancer. Low BMI was associated with increased mortality in type I (HR, 2.07; 95% confidence interval [CI], 1.20-3.55), whereas in type II both low (HR, 1.68; 95% CI, 1.03-2.74) and high BMI (BMI, 30-35: HR, 1.54; 95% CI, 1.01-2.26 and BMI >40: HR, 2.15; 95% CI, 1.12-4.11) were significantly associated with increased mortality.CONCLUSION: Abnormal BMI is associated with increased mortality in subtypes of endometrial cancer. Underweight was associated with increased overall mortality in both types I and II, whereas obesity only disclosed a significant impact on overall mortality in type II.
AB - OBJECTIVE: To evaluate the influence of body mass index (BMI) on endometrial tumor pathology, stage and complication rate and to identify individual prognostic factors, such as BMI, in types I and II endometrial cancer.DESIGN: Register study included all Danish women who underwent surgery for uterine cancer or atypical endometrial hyperplasia (International Classification of Diseases-10 codes D070, DC549) 2005 to 2012 (n = 6003).MAIN OUTCOME MEASURES: Impact of BMI on type I and II endometrial cancer survival.MATERIALS AND METHODS: Danish Gynecological Cancer Database data on women with type I and II endometrial cancer were retrieved. Kaplan-Meier plot was used to illustrate differences in survival in relation to BMI. Log-rank test was used to demonstrate difference between the curves. Cox regression hazard model was used to estimate hazard ratios (HR) of the effect of BMI on overall survival.RESULTS: Four thousand three hundred thirty women were included. Women with type I cancer had a significantly better overall survival compared with those with type II cancer. Low BMI was associated with increased mortality in type I (HR, 2.07; 95% confidence interval [CI], 1.20-3.55), whereas in type II both low (HR, 1.68; 95% CI, 1.03-2.74) and high BMI (BMI, 30-35: HR, 1.54; 95% CI, 1.01-2.26 and BMI >40: HR, 2.15; 95% CI, 1.12-4.11) were significantly associated with increased mortality.CONCLUSION: Abnormal BMI is associated with increased mortality in subtypes of endometrial cancer. Underweight was associated with increased overall mortality in both types I and II, whereas obesity only disclosed a significant impact on overall mortality in type II.
KW - Journal Article
U2 - 10.1097/IGC.0000000000000874
DO - 10.1097/IGC.0000000000000874
M3 - Journal article
C2 - 27922975
VL - 27
SP - 281
EP - 288
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
SN - 1048-891X
IS - 2
ER -
ID: 176897596