Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study

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Standard

Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients : from the Danish 'MALOVA' ovarian cancer study. / Heeran, Mel C; Høgdall, Claus K; Kjaer, Susanne K; Christensen, Lise Hanne; Blaakaer, Jan; Christensen, Ib Jarle; Hogdall, Estrid V S.

I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, Bind 120, Nr. 10, 2012, s. 846-54.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Heeran, MC, Høgdall, CK, Kjaer, SK, Christensen, LH, Blaakaer, J, Christensen, IJ & Hogdall, EVS 2012, 'Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, bind 120, nr. 10, s. 846-54. https://doi.org/10.1111/j.1600-0463.2012.02913.x

APA

Heeran, M. C., Høgdall, C. K., Kjaer, S. K., Christensen, L. H., Blaakaer, J., Christensen, I. J., & Hogdall, E. V. S. (2012). Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, 120(10), 846-54. https://doi.org/10.1111/j.1600-0463.2012.02913.x

Vancouver

Heeran MC, Høgdall CK, Kjaer SK, Christensen LH, Blaakaer J, Christensen IJ o.a. Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study. A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 2012;120(10):846-54. https://doi.org/10.1111/j.1600-0463.2012.02913.x

Author

Heeran, Mel C ; Høgdall, Claus K ; Kjaer, Susanne K ; Christensen, Lise Hanne ; Blaakaer, Jan ; Christensen, Ib Jarle ; Hogdall, Estrid V S. / Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients : from the Danish 'MALOVA' ovarian cancer study. I: A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica. 2012 ; Bind 120, Nr. 10. s. 846-54.

Bibtex

@article{492682be3fd5489f874cbc4d815490bc,
title = "Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish 'MALOVA' ovarian cancer study",
abstract = "The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.",
author = "Heeran, {Mel C} and H{\o}gdall, {Claus K} and Kjaer, {Susanne K} and Christensen, {Lise Hanne} and Jan Blaakaer and Christensen, {Ib Jarle} and Hogdall, {Estrid V S}",
note = "{\textcopyright} 2012 The Authors APMIS {\textcopyright} 2012 APMIS.",
year = "2012",
doi = "10.1111/j.1600-0463.2012.02913.x",
language = "English",
volume = "120",
pages = "846--54",
journal = "A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica",
issn = "0903-4641",
publisher = "Wiley Online",
number = "10",

}

RIS

TY - JOUR

T1 - Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients

T2 - from the Danish 'MALOVA' ovarian cancer study

AU - Heeran, Mel C

AU - Høgdall, Claus K

AU - Kjaer, Susanne K

AU - Christensen, Lise Hanne

AU - Blaakaer, Jan

AU - Christensen, Ib Jarle

AU - Hogdall, Estrid V S

N1 - © 2012 The Authors APMIS © 2012 APMIS.

PY - 2012

Y1 - 2012

N2 - The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.

AB - The primary objective of this study was to assess the expression of cyclin E in tumour tissues from 661 patients with epithelial ovarian tumours. The second was to evaluate whether cyclin E tissue expression levels correlate with clinico-pathological parameters and prognosis of the disease. Using tissue arrays (TA), we analysed the cyclin E expression levels in tissues from 168 women with borderline ovarian tumours (BOT) (147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC) patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a 10% cut-off level for cyclin E overexpression, 20% of the BOTs were positive with a higher proportion of serous than mucinous tumours. Sixty-two per cent of the OCs were positive for cyclin E expression with the highest percentage found in clear cell carcinomas. Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.

U2 - 10.1111/j.1600-0463.2012.02913.x

DO - 10.1111/j.1600-0463.2012.02913.x

M3 - Journal article

C2 - 22958293

VL - 120

SP - 846

EP - 854

JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica

SN - 0903-4641

IS - 10

ER -

ID: 48466840